The neural pathways mediating quiet-biting attack behavior from the hypothalamus in the cat: A functional autoradiographic study

Electrical stimulation of the region of the lateral hypothalamus produced a consistent form of quiet-biting attack behavior in cats. In one series of experiments, cats, implanted with electrodes from which attack had been elicited, were anesthetized and then were injected with a bolus of ¹⁴C-2-deoxyglucose at the same time as electrical stimulation was delivered through the attack electrodes. Brains prepared for X-ray autoradiography revealed that lateral hypothalamic stimulation activated the classical medial forebrain bundle pathway supplying the septal region, diagonal band, lateral preoptic area, and ventral tegmental region. Stimulation of quiet-attack sites in perifornical hypothalamus resulted in the activation of a much more extensive projection system which included the central and lateral tegmental fields of the midbrain and pons, and central gray region, as well as the structures described above. In a second series of experiments, ³H-leucine was placed into the region of the electrode tip from which attack was elicited in order to identify more precisely the pathways arising from that site. In general, tritiated amino acid radioautography replicated the ¹⁴C-2-deoxyglucose findings. In addition, the amino acid radioautographic data revealed the presence of extensive projections from perifornical hypothalamus to such pontine structures as the nucleus locus coeruleus, motor nucleus of NV , and the lateral pontine tegmental field. The functional connections between the lateral hypothalamic “attack region” and lateral preoptic zone were also confirmed by electrophysiological methods.     

The "what" and "where" of object representations in infancy

Four-month-olds' memory for surface feature and location information was tested following brief occlusions. When the target objects were images of female faces or monochromatic asterisks infants showed increased looking times following a change in identity or color but not following a change in location or combinations of feature and location information. When the target objects were images of manipulable toys, the infants showed increased looking times following a change in location but not identity or the binding of location and identity information. This evidence is consistent with the idea that young infants are unable to maintain the information processed separately in both the dorsal and ventral visual streams during occlusions. Our results suggest that it is the target's affordance for action that determines whether the dorsal or ventral information is selectively maintained during occlusion.     

A cross-sectional and longitudinal analysis of reward-related brain activation: Effects of age,pubertal stage,and reward sensitivity

Neurobiological models suggest that adolescents are driven by an overactive ventral striatum (VS) response to rewards that may lead to an adolescent increase in risk-taking behavior. However, empirical studies showed mixed findings of adolescents’ brain response to rewards. In this study, we aimed to elucidate the relationship between reward-related brain activation and risky decision-making. In addition, we examined effects of age, puberty, and individuals’ reward sensitivity. We collected two datasets: Experiment 1 reports cross-sectional brain data from 75 participants (ages 10–25) who played a risky decision task. Experiment 2 presents a longitudinal extension in which a subset of these adolescents (n = 33) was measured again 2 years later. Results showed that (1) a reward-related network including VS and medial PFC was consistently activated over time, (2) the propensity to choose the risky option was related to increased reward-related activation in VS and medial PFC, and (3) longitudinal comparisons indicated that self-reported reward sensitivity was specifically related to VS activation over time. Together, these results advance our insights in the brain circuitry underlying reward processing across adolescence.     

The amygdalostriatal and corticostriatal effective connectivity in anticipation and evaluation of facial attractiveness

Decision-making consists of several stages of information processing, including an anticipation stage and an outcome evaluation stage. Previous studies showed that the ventral striatum (VS) is pivotal to both stages, bridging motivation and action, and it works in concert with the ventral medial prefrontal cortex (vmPFC) and the amygdala. However, evidence concerning how the VS works together with the vmPFC and the amygdala came mainly from neuropathology and animal studies; little is known about the dynamics of this network in the functioning human brain. Here we used fMRI combined with dynamic causal modeling (DCM) to investigate the information flow along amygdalostriatal and corticostriatal pathways in a facial attractiveness guessing task. Specifically, we asked participants to guess whether a blurred photo of female face was attractive and to wait for a few seconds (“anticipation stage”) until an unblurred photo of feedback face, which was either attractive or unattractive, was presented (“outcome evaluation stage”). At the anticipation stage, the bilateral amygdala and VS showed higher activation for the “attractive” than for the “unattractive” guess. At the outcome evaluation stage, the vmPFC and the bilateral VS were more activated by feedback faces whose attractiveness was congruent with the initial guess than by incongruent faces; however, this effect was only significant for attractive faces, not for unattractive ones. DCM showed that at the anticipation stage, the choice-related information entered the amygdalostriatal pathway through the amygdala and was projected to the VS. At the evaluation stage, the outcome-related information entered the corticostriatal pathway through the vmPFC. Bidirectional connectivities existed between the vmPFC and VS, with the VS-to-vmPFC connectivity weakened by unattractive faces. These findings advanced our understanding of the reward circuitry by demonstrating the pattern of information flow along the amygdalostriatal and corticostriatal pathways at different stages of decision-making.     

Open field habituation learning is improved by nicotine and attenuated by mecamylamine administered posttrial into the nucleus accumbens

Using the paradigm of habituation learning in the open field, we tested the effects of unilateral microinjections of the agonist nicotine (8.0, 40.0, and 80.0 microg) and the nicotine receptor antagonist mecamylamine (0.1, 1.0, 10.0 microg) into the core of the nucleus accumbens. When injected posttrial, that is, immediately after the first exposure to the open field, nicotine dose-dependently enhanced behavioral habituation during the test on the following day, indicating a facilitation of memory, whereas mecamylamine impaired habituation at the highest dose, but not at the two lower doses. When injected 5 h after the learning trial, nicotine (40 microg) and mecamylamine (10 microg) impaired habituation on the subsequent day. A control experiment did not provide evidence for possible proactive effects of mecamylamine. These findings are discussed with respect to the possible behavioral functions of cholinergic, and especially nicotinic, mechanisms in the nucleus accumbens. They may also be relevant for understanding cholinergic-linked psychopathologies such as Alzheimer's disease, since the nucleus accumbens is one of the sites where cholinergic neurons are lost in this neurodegenerative disease.     

Interactions of reading and semantics along the ventral visual processing stream

Converging evidence supports a distributed-plus-hub view of semantic processing, in which there are distributed modular semantic sub-systems (e.g., for shape, colour, and action) connected to an amodal semantic hub. Furthermore, object semantic processing of colour and shape, and lexical reading and identification, are processed mainly along the ventral stream, while action semantic processing occurs mainly along the dorsal stream. In Experiment 1, participants read a prime word that required imagining either the object or action referent, and then named a lexical word target. In Experiments 2 and 3, participants performed a lexical decision task (LDT) with the same targets as in Experiment 1, in the presence of foils that were legal nonwords (NW; Experiment 2) or pseudohomophones (PH; Experiment 3). Semantic priming was similar in effect size regardless of prime type for naming, but was greater for object primes than action primes for the LDT with PH foils, suggesting a shared-stream advantage when the task demands focus on orthographic lexical processing. These experiments extend the distributed-plus-hub model, and provide a novel paradigm for further research.     

Speech Perception: Cognitive Foundations and Cortical Implementation

ABSTRACT— Speech perception includes, minimally, the set of computations that transform continuously varying acoustic signals into linguistic representations that can be used for subsequent processing. The auditory and motor subroutines of this complex perceptual process are executed in a network of brain areas organized in ventral and dorsal parallel pathways, performing sound-to-meaning and sound-to-motor mappings, respectively. Research on speech using neurobiological techniques argues against narrow motor or auditory theories. To account for the range of cognitive and neural attributes, integrative computational models seem promising.     

Infants perceive human point-light displays as solid forms

While five-month-old infants show orientation-specific sensitivity to changes in the motion and occlusion patterns of human point-light displays, it is not known whether infants are capable of binding a human representation to these displays. Furthermore, it has been suggested that infants do not encode the same physical properties for humans and material objects. To explore these issues we tested whether infants would selectively apply the principle of solidity to upright human displays. In the first experiment infants aged six and nine months were repeatedly shown a human point-light display walking across a computer screen up to 10 times or until habituated. Next, they were repeatedly shown the walking display passing behind an in-depth representation of a table, and finally they were shown the human display appearing to pass through the table top in violation of the solidity of the hidden human form. Both six- and nine-month-old infants showed significantly greater recovery of attention to this final phase. This suggests that infants are able to bind a solid vertical form to human motion. In two further control experiments we presented displays that contained similar patterns of motion but were not perceived by adults as human. Six- and nine-month-old infants did not show recovery of attention when a scrambled display or an inverted human display passed through the table. Thus, the binding of a solid human form to a display in only seems to occur for upright human motion. The paper considers the implications of these findings in relation to theories of infants' developing conceptions of objects, humans and animals.     

腹侧通路与背侧通路在词汇阅读中的作用

腹侧通路与背侧通路是视觉加工的两条通路。随着认知神经科学的发展,研究发现腹侧和背侧通路与词汇阅读有关。其中腹侧通路与词汇识别有关,背侧通路与阅读的关系比较复杂。本文简要回顾了两条通路在词汇阅读中的作用。