个人化设计在临床研究中的应用——从个体角度研究个体差异

本文从有关研究证据的基础上,介绍了个人化设计的理论基础和实验设计,并在此基础上讨论了个人化设计在临床研究领域中的应用价值,总结出一种适合临床病人使用的研究程序。个人化设计允许对个体的个人价值进行分析,并能同时研究不同刺激信息的作用,在个体水平上分析个体差异。通过简化了的实验程序,个人化设计为解决临床研究中的问题提供了一种新的思维方式。文中还对相关研究法的局限进行了讨论。     

Sequential effects in dimensional contrast

Two experiments examined pigeons' response rates during short trials signaled by stimuli closely spaced along a wavelength continuum. In Experiment 1 separate halves of the continuum were correlated with different reinforcement schedules. In Experiment 2, the middle stimulus was accompanied by a lower probability of reinforcement than were the remaining wavelengths. Both procedures resulted in dimensional contrast “shoulders,” seen as relatively enhanced or depressed response rates in the presence of stimuli between the extreme of the continuum and the border separating the positive and negative stimuli. Sequential analyses addressed possible contributions of the following interactions: (a) local contrast, seen when rate during a given schedule depends on the schedule in the just-preceding trial; (b) modification of local contrast by the similarity of the signaling stimuli (P. Blough, 1983); and (c) schedule-independent rate contrast, seen when rate in a given trial depends on the rate controlled by the stimulus that accompanied the just-preceding trial (Malone & Rowe, 1981). Dimensional contrast functions were similar when isolated according to the schedule, to the similarity of the signaling stimulus, and to the response rate of the just-preceding trial. The interactions noted above do not appear to make important contributions to this effect.     

Latent trait models and dichotomization of graded responses

This paper discusses thecompatibility of the polychotomous Rasch model with dichotomization of the response continuum. It is argued that in the case of graded responses, the response categories presented to the subject are essentially an arbitrary polychotomization of the response continuum, ranging for example from total rejection or disagreement to total acceptance or agreement of an item or statement. Because of this arbitrariness, the measurement outcome should be independent of the specific polychotomization applied, for example, presenting a specific multicategory response format should not affect the measurement outcome. When such is the case, the original polychotomous model is called compatible with dichotomization.A distinction is made between polychotomization or dichotomization before the fact, that is, in constructing the response format, and polycho- or dichotomization after the fact, for example in dichotomizing existing graded response data.It is shown that, at least in case of dichotomization after-the-fact, the polychotomous Rasch model is not compatible with dichotomization, unless a rather special condition of the model parameters is met. Insofar as it may be argued that dichotomization before the fact is not essentially different from dichotomization after the fact, the value of the unidimensional polychotomous Rasch model is consequently questionable. The impact of our conclusion on related models is also discussed.     

A Logic for Reasoning about Relative Similarity

A similarity relation is a reflexive and symmetric binary relation between objects. Similarity is relative: it depends on the set of properties of objects used in determining their similarity or dissimilarity. A multi-modal logical language for reasoning about relative similarities is presented. The modalities correspond semantically to the upper and lower approximations of a set of objects by similarity relations corresponding to all subsets of a given set of properties of objects. A complete deduction system for the language is presented.     

The Development of the Toddler Behavior Screening Inventory

The purpose of the present study was to develop the Toddler Behavior Screening Inventory (TBSI) for rapidly assessing maternal reports of toddler behavior problems. The TBSI is a 40-item measure intended for use by pediatricians, psychologists, and other child-care professionals. A group of mothers (n = 312) rated the initial 93-item TBSI in terms of behavior frequency and parental perception of the behavior as problematic. Following item elimination, 40 items were retained due to being both frequent and problematic at all toddler age levels. Data were obtained with a new sample of mothers (n = 581) and showed the TBSI to possess good reliability and validity.     

Similarities derived from 3-d nonlinear psychophysics: Variance distributions

Many-one mappings between stimulus properties and pairwise generated similarities are intrinsic to definitions of similarity. This of itself is not sufficient as a basis for predicting the variance associated with any single similarity judgment. An extension to cover this has to be made either by making ancillary assumptions about noise, or by using nonlinear models. The derivation of the variance of similarity judgments is made from the 3 process in nonlinear psychophysics. The idea of separability of dimensions in metric space theories of similarity is replaced by one parameter which represents the degree of a form of interdimensional crosscoupling     

Human d-amphetamine drug discrimination: methamphetamine and hydromorphone.

Standard measures of subjective and discriminative effects of drugs were compared in 5 human volunteers. Subjects responded on a second-order color-tracking procedure, where 30 mg of d-amphetamine served as a discriminative stimulus for one response and its absence as the discriminative stimulus for another response. Self-reported subjective effects were assessed concurrently using the single-dose questionnaire, subscales of the Addiction Research Center Inventory, and several analogue rating scales. On different days following discrimination acquisition, varying doses of d-amphetamine, methamphetamine, and hydromorphone were administered. In these test sessions, either response was reinforced. Methamphetamine and d-amphetamine occasioned dose-related increases in d-amphetamine appropriate responding; hydromorphone did not. Methamphetamine and d-amphetamine occasioned dose-related increases in reports of the drug received being most like "speed"; hydromorphone occasioned dose-related increases in reports of the drug received being most like "dope." All three drugs occasioned dose-related increases in reports of drug liking, and increases in the morphine-benzedrine group, amphetamine, and benzedrine group scales of the Addiction Research Center Inventory. This experiment demonstrated that although explicit discriminative control of behavior by a drug may covary with drug identification, it does not necessarily covary with other self-reported subjective effects. Thus, the complementary nature of the data provided by drug discrimination and standard subjective-effects measures provides quantitative and qualitative data useful in studying both relatively novel compounds and the behavioral biology of psychoactive drugs in general.     

The Revised Conners' Parent Rating Scale (CPRS-R): Factor Structure, Reliability, and Criterion Validity

The Conners' Parent Rating Scale (CPRS) is a popular research and clinical tool for obtaining parental reports of childhood behavior problems. The present study introduces a revised CPRS (CPRS-R) which has norms derived from a large, representative sample of North American children, uses confirmatory factor analysis to develop a definitive factor structure, and has an updated item content to reflect recent knowledge and developments concerning childhood behavior problems. Exploratory and confirmatory factor-analytic results revealed a seven-factor model including the following factors: Cognitive Problems, Oppositional, Hyperactivity-Impulsivity, Anxious-Shy, Perfectionism, Social Problems, and Psychosomatic. The psychometric properties of the revised scale appear adequate as demonstrated by good internal reliability coefficients, high test-retest reliability, and effective discriminatory power. Advantages of the CPRS-R include a corresponding factor structure with the Conners' Teacher Rating Scale—Revised and comprehensive symptom coverage for attention deficit hyperactivity disorder (ADHD) and related disorders. Factor congruence with the original CPRS as well as similarities with other parent rating scales are discussed.     

系列范畴词表时序记忆和项目记忆研究

该项研究探讨系列范畴词表的时序长时记忆和项目长时记忆,实验设计的系列范畴词表将记忆项目分为词表内范畴相同项和词表间范畴相同项,时序记记测量方法是词表辨认,项目记忆测量方法是自由回忆。实验一发现：２分钟延缓测试词表内范畴相同项时序记忆和项目记忆优于词表间范畴相同项;６分钟以及１０分钟延缓测试时序记忆仍是词表内范畴相同项好。实验二发现：以范畴线索提取,两类项目记忆没有显著差异;以词表线索提取,两类项目