Theory change in immunology part II: The clonal selection theory

This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part II these factors, as elaborated in the Bayesian framework, are applied to the case of the success of the clonal selection theory and the failure of the instructive theory.     

RESCUE AND RECOVERY AS A THEOLOGICAL PRINCIPLE,AND A KEY TO MORALITY IN EXTRATERRESTRIAL SPECIES

New theological understanding can emerge with the advancement of scientific knowledge and the use of new concepts, or older concepts in new ways. Here, the authors present a proposal to extend the concept of “rescue and recovery” found in the United Nations Law of the High Seas, off-world and within a broader purview of other intelligent and self-aware species that humans may someday encounter. The notion of a morality that extends to off-world species is not new, but in this analysis, rescue and recovery become an imperative when any intelligent and self-aware species is in harm's way. Rescue and recovery encompass a necessary action component except perhaps in those cases where rescuers are in danger. The authors explore three biblical examples of rescue and recovery to derive a fundamental meaning of the concept.     

Effect of Daily Life Reward Loop Functioning on the Course of Depression

Engagement in activities increases positive affect (Reward Path 1), which subsequently reinforces motivation (Reward Path 2), and hence future engagement in activities (Reward Path 3). Strong connections between these three reward loop components are considered adaptive, and might be disturbed in depression. Although some ecological nomentary assessment (EMA) studies have investigated the cross-sectional association between separate reward paths and individuals’ level of depression, no EMA study has looked into the association between individuals’ reward loop strength and depressive symptom course. The present EMA study assessed reward loop functioning (5x/day, 28 days) of 46 outpatients starting depression treatment at secondary mental health services and monitored with the Inventory of Depressive Symptomatology—Self-Report (IDS-SR) during a 7-month period. Results of multilevel regression analyses showed significant within-person associations for Reward Path 1 (b = 0.21, p < .001), Reward Path 2 (b = 0.43, p < .001), and Reward Path 3 (b = 0.20, p < .001). Stronger average reward loops (i.e., within-person mean of all reward paths) did not relate to participants’ improvement in depressive symptoms over time. Path-specific results revealed that Reward Paths 1 and 2 may have partly opposite effects on depressive symptom course. Together, our findings suggest that reward processes in daily life might be best studied separately and that further investigation is warranted to explore under what circumstances strong paths are adaptive or not.     

Positive conditioned suppression: Transfer of performance between contingent and noncontingent reinforcement situations

Five homing pigeons were trained on concurrent variable-interval schedules. A fixed-duration stimulus was occasionally presented on one key; and, in various conditions, this stimulus terminated (a) without reinforcement, (b) in noncontingent reinforcement, (c) with reinforcement contingent on a response on the key on which the stimulus was presented, and (d) with reinforcement contingent on a response on the key on which the stimulus was not presented. Initially, a stimulus terminating in noncontingent reinforcement generally produced decreased response rates on both keys during the stimulus. Contingencies, however, reliably produced increased rates during the stimulus on the key on which the contingency was arranged, relative to the rate on the concurrently available key. Contingency conditions were followed by noncontingency conditions in which the separation of rates caused by contingencies was maintained. When rates during the stimulus were compared with response rates on the same keys in the absence of the stimulus, contingency-caused rate increases and decreases were again found, but only the rate decreases were maintained in subsequent noncontingency conditions. Further data suggested that the contingency-caused rate changes were not maintained when the stimulus terminated without reinforcement, and that they were unaffected by a threefold decrease in the reinforcement rate provided by the baseline schedules. The results support the suggestion that performance in the positive conditioned suppression procedure results from concurrent and multiple schedule interactions. They further suggest that the production of either acceleration or suppression is dependent on adventitious and historical contingencies.     

IDENTIFYING THE EDUCATIVE AND SUPPRESSIVE EFFECTS OF POSITIVE PRACTICE AND RESTITUTIONAL OVERCORRECTION

Two major features of the overcorrection procedure, restitution and positive practice, were analyzed for their educative and suppressive properties in the treatment of profoundly retarded adults. Positive practice techniques that were topographically similar and dissimilar to the target behavior were studied. Eating behavior and puzzle performance were observed. Restitutional overcorrection and both forms of positive practice were effective for suppressing inappropriate behaviors. Even when appropriate behaviors had been acquired by positive practice, restitution and dissimilar positive practice were generally ineffective for increasing their rate of occurrence. However, topographically similar positive practice was successful as a means of teaching new appropriate behaviors.     

Preferences for skill versus chance-determined activities: The influence of gender and task sex-typing

Three experiments tested the hypothesis that skill-chance activity preference by men and women is moderated by task sex relatedness. Men and women (total N = 368) opted to perform either skill or chance versions of masculine and feminine tasks, and then provided ratings of performance expectancy, importance of success, and perceptions of task characteristics. Results support the conclusion that men do not prefer skill and women chance as had been found previously, but rather that while men's skill preferences are higher than women's on a masculine taks, women prefer skill more than do men on a feminine task. Skill-chance preferences were primarily a function of the expectancy of success on skill tasks.     

Correspondence between saying and doing: Some thoughts on defining correspondence and future directions for application

Israel (1978) evaluated and discussed research on positive and negative verbal-nonverbal correspondence. In the present report we attempt to delineate the relationship of correspondence training to two major intervention goals-producing (increasing) behavior and inhibiting (decreasing) behavior. The concepts of noncorrespondence and generalized positive correspondence are introduced. Past research relating to the correspondence analyses offered for the two intervention outcomes and possibilities for future research are discussed. The relationship of verbal correspondence training to the issues of response maintenance and response generalization is also examined.