从诺贝尔医学奖获取教益

通过对诺贝尔医学奖100余年获奖项目和获奖者的分析研究,发现创造性成果获奖多,基础研究成果获奖多,获奖者大多具有多学科的知识结构,获奖者大多出自一流的学术环境和获奖者都具有崇高的精神品质等特点.并且指出,我国要向诺贝尔医学奖迈进,就必须重视创造性、基础性成果的研究,必须重视和加强医学工作者和医学生创造性和综合素质的培养,必须营造有国际级科学大师引领的世界一流的学术环境.     

The influence of competitive status (winner/loser) on the behavior of male rats in three models of anxiety

Studies indicate that features such as prior stressful experience, strain, gender, and age can influence the behavior of rats in animal models of anxiety. In the present study, we examined the possible influence of competitive status (winner/loser) in three such models: the elevated plus‐maze, the open field, and the social interaction test. One hundred to 135‐day‐old male Wistar rats were conditioned to traverse a straight runway tube to obtain food. Subsequently, two rats were placed at the same time in the runway tube and, being unable to pass each other, one of them pushed the other to the opposite end‐box. The rats were categorized as winners or losers in this competition. One week after the straight runway tube test, the rats were submitted to the anxiety models, where it was observed that winner rats showed greater locomotor activity than the losers in the three models studied. Furthermore, winner rats showed less immobility and higher central and total locomotor activity in the open field and a greater duration of social interaction in the social interaction test. These results suggest that competitive status has an influence on the locomotor activity of rats in animal models of anxiety. However, whether competitive status influences anxiety as assessed in these models is unclear, and further investigations are warranted. Aggr. Behav. 28:164–171, 2002. © 2002 Wiley‐Liss, Inc.     

When Does the Honeymoon End? Electoral Cycles of Satisfaction With Democracy in Africa

Scholars have argued that multiparty elections have a profound and immediate influence on mass evaluations of political support. However, what is less clear is whether the effects of elections are short lived or long lasting. Investigating dynamic effects of elections on mass perceptions of political regimes has profound implications on popular foundations of democratic consolidation in an era of democratic backsliding. This article examines electoral cycles in citizens' satisfaction with democracy (SWD)—an important dimension of political support—in multiparty regimes. First, we argue that proximity to elections enhances SWD because campaigns and elections include several processes that reduce the costs and increase the benefits of citizen engagement with the political system. This results in a bell-shaped relationship between citizens' proximity to elections and SWD. Second, we contend that electoral cycles in SWD should vary by the quality of elections and citizens' winner/loser status. We examine these hypotheses using Afrobarometer data in 34 multiparty regimes between 1999 and 2015 finding compelling support. SWD is higher among respondents surveyed closer to elections, while electoral cycles in SWD are more prominent among winners and around low-quality elections.     

药物临床试验设计的伦理思考

目前广泛采用的药物临床试验设计中,由于不能使受试者最大限度的受益而在伦理学方面存在弊端。自适应设计方法的出现,为克服这一弊端提供了现实途径,可使药物临床试验的受试者能够最大程度的受益。本文从传统临床试验引发的伦理问题入手,阐述了自适应设计以人为本的特点,探讨了其在解决伦理与疗效冲突问题中的重要作用。     

成功经历能改善低耐挫大学生的挫折心理

为考察多次成功对低耐挫大学生挫折心理的改善,研究1以高、中、低耐挫大学生为被试,采用图形推理任务创设挫折-连续成功情境（即先经历挫折,后经历多次成功）;研究2以高、低耐挫大学生为被试,采用部件组字任务创设挫折-连续成功情境。结果发现,在经历挫折后：（1）成功1次能改善大学生的成功坚信程度,连续成功6或7次能使其趋于稳定;（2）成功1次能改善低耐挫大学生的情绪体验,连续成功6次能使其相对稳定;（3）成功1次能改善低耐挫大学生的继续意愿,连续成功7次能使其趋于稳定。表明多次成功能改善低耐挫大学生的挫折心理。     

Behavioral correlates of learned aggression in male mice

The aims of this paper are to study the aggressive behavior in male mice with consecutive experience of victories in 2, 10, and 20 days (T2, T10, and T20 winners) of daily agonistic confrontations under the sensory contact model and to determine the most probable behavioral domains that should be used as animal models for learned aggression in humans. It has been shown that the structure of winners' behavior changes from test to test: the attacking behavior prevailed (81% of the total time) in the behavior of T2 winners. Attacks and diggings (herein: digging up and scattering the litter on the partner' territory) prevailed in the behavior of T10 winners (each approximately 40%). T20 winners demonstrated aggressive grooming half of the testing time and digging behavior 25% of the time. Correlational analysis revealed that the number of significant correlations between the behavioral domains (attacking, digging, aggressive grooming, self‐grooming, threats, rotations) and between different behavioral parameters (latency, number, total and average time) of one behavioral domain are growing from the second test to twentieth test, and the relationships between the behavioral domains change qualitatively. The following may be regarded as elements of learned aggression in male mice: (1) appearance of aggressive grooming instead of the intensive attacking behavior and (2) involvement of the digging behavior in the hostile behavior together with the threats and attacking behavior. Negative correlations between parameters of the behavioral domains may testify to the replacement of one behavioral pattern by another and reflect learned behavior. Positive correlations between certain behavioral domains may reflect the formation of a common motivational background for the winners' behavior. Aggr. Behav. 26:386–400, 2000. © 2000 Wiley‐Liss, Inc.     

An experimental approach to the study of learned aggression

The sensory contact technique increases aggressiveness in male mice and allows aggressive types of behavior to be formed as a result of the repeated experience of victories in daily agonistic confrontations. Some behavioral domains confirm the development of learned aggression in males similar to those in humans. The features are repeated experience of aggression reinforced by victories; elements of learned behavior after periods of confrontation; intent, measured by increase of the aggressive motivation prior to agonistic confrontation; and decreased emotionality, estimated by parameters of open‐field behavior. Relevant situation provokes increases in aggression (boundary aggression). This review summarizes data on the influence of positive fighting experience in daily intermale confrontations on the behavior, neurochemistry, and physiology of aggressive mice (winners). This sort of experience changes many characteristics in individual and social behaviors, these having been estimated in different tests and in varied situations. Some physiological parameters are also changed in the winners. Neurochemical data confirm the activation of brain dopaminergic systems and functional inhibition of serotonergic system in winners under the influence of the repeated experience of aggression. The expression of the neurochemical and behavioral changes observed in winners has been found to depend on the mouse strain and on the duration of their agonistic confrontations. Aggr. Behav. 26:241–256, 2000. © 2000 Wiley‐Liss, Inc.     

赢者诅咒：心理机制、影响因素及应对策略

赢者诅咒是指在拍卖情境中, 竞价者为了获得拍卖品会过高估计其价值, 竞价成功以后当他发现其价值和自己之前的期望不一致时所产生的一种“诅咒”心理。赢者诅咒现象普遍存在于企业的资产拍卖、兼并重组、博彩游戏、投资决策等领域。损失规避和过度自信理论是赢者诅咒的主要心理机制, 而其影响因素主要有竞拍商品价值的不确定性、竞价人数、信息因素和竞价经验等。赢者诅咒的应对策略主要包括联合竞标、信息共享和学习。未来对赢者诅咒的研究需要进一步探讨赢者诅咒的心理机制、研究范式及本土化等问题。