感染性休克患者术前应用盐酸戊乙奎醚的临床疗效

观察盐酸戊乙奎醚在感染性休克患者中作为术前药应用的临床疗效。感染性休克手术患者40例,随机分为2组：实验组术前30min肌注盐酸戊乙奎醚lmg,对照组肌注东莨菪碱0．3mg。于各时间点检测血乳酸值、血气（PaO2、PaCO2）及胃黏膜二氧化碳分压（PgCO2）。结果示实验组血乳酸下降、PaO2上升,PgCO2一PaCO...     

盐酸戊乙奎醚对输尿管痉挛的预防作用

为了评价盐酸戊乙奎醚对输尿管镜手术中输尿管痉挛的预防作用,将60例拟行经尿道输尿管镜手术的患者随机分为两组,试验组和对照组,每组30例。两组患者均接受硬膜外阻滞,试验组于术前给予盐酸戊乙奎醚0.02mg／kg静脉注射,对照组则接受等量的生理盐水注射。记录术中输尿管痉挛的发生情况,外科医生对手术条件的评分以及术后患者的口干情况。结果显示,试验组输尿管痉挛发生率明显低于对照组,外科医生评分则高于对照组,但术后试验组患者的口干较为明显。提示盐酸戊乙奎醚能够预防输尿管镜手术中输尿管痉挛的发生。     

盐酸戊乙奎醚对心脏瓣膜置换术患者NF-κB表达的影响

为研究盐酸戊乙奎醚对心脏瓣膜置换术患者心肌NF-κB转录活性的影响,选取择期瓣膜置换术患者60例,随机分为对照组（C）、盐酸戊乙奎醚组1（P1）、盐酸戊乙奎醚组2（P2）,每组20例。结果心肌缺血再灌注后,P1、P2组NF-κB的转录活性明显下降,可见盐酸戊乙奎醚可以抑制心肌NF-κB的激活,在一定程度上具有心肌保护作用。     

Prey-dependent effects of fluprazine hydrochloride on predatory aggression in northern grasshopper mice (Onychomys leucogaster) and rats (Rattus norvegicus)

Treatment with the phenylpiperazine DU 27716 (fluprazine hydrochloride) inhibited the predatory killing of albino mice by northern grasshopper mice (Onychomys leucogaster) and of frogs by rats. This treatment had no effect on cricket predation by grasshopper mice or worm predation by rats. The prey-specific effect of fluprazine did not seem to result from a decreased tendency to attack nor was its effect restricted to prey showing characteristic rodent defensive responses. Rather, the drug seemed to increase fearfulness when the prey exhibited vigorous defensive behavior. It is possible that increased fearfulness induced by treatment with this drug may also contribute to its antioffensive effect during conspecific encounters.     

高血压治疗:百年历程、日益细化

人类对高血压的治疗是百年以来医学的重要成就.越来越多的证据表明,有效控制高血压是降低相关疾病发病、死亡、致残的重要手段.医学对高血压治疗药物、手段、方案的探索尚未止步,许多正在进展中.