大剂量抗坏血酸静脉滴注治疗恶性肿瘤的进展

尽管30年前鲍林与卡梅伦曾经用静脉注射+口服大剂量维生素C(10克/天)治疗肿瘤患者,并验证抗坏血酸的抗癌功效,但梅约医疗中心的口服双盲试验否定了他们的结论.沉寂30年后,鲍林的继承者瑞欧丹通过不懈的努力用科学实验和医疗实践证明,通过静脉滴注大剂量抗坏血酸,令其在血浆达到一定浓度,可以杀死多种癌细胞,从而作为化疗药物可以有效治疗恶性肿瘤.30年来的临床实践现已总结为“瑞欧丹规程”.近年来,他们的成就受到美国主流医学和媒体的高度重视.与一般化疗药物相比,该法的好处是基本没有副作用,延长生存期,提高存活质量(QOF).这是一项重大科学发现和成就.该疗法的确立意义重大,将推动癌的治疗及预防,乃至其他疾病如冠心病、感染性疾病及炎症的治疗及预防,提高人类健康水平.     

The influence of surgical stress,anxiety and benzodiazepine intravenous sedation on recall of oral surgery

Abstract

This study, part of a larger investigation of the efficacy and safety of intravenous sedation in dentistry, reports the prevalance of failure to recall information during third molar impaction surgery and attempts to differentate the effects of stress and benzodiazepines on recall. Both recognition of neutral pictures and the recall of surgical procedures were assessed. Recall failure in the drug groups ranged from zero for recall of stressful procedures, completed before drug titration, to 92 percent of subjects for recognition of the neutral picture presented at 5 minutes after the surgical procedure began. Placebo condition subjects had almost no recall loss. Recall failure was demonstrated to be primarily a function of the volume of midazolam employed. However, operative stress and trait and state anxiety explained some of the findings.     

腹部手术后舒芬太尼持续硬膜外镇痛与静脉镇痛的比较

采用双盲、前瞻性研究,在 60例年龄30岁～50岁,ASAⅠ-Ⅱ级,BMI（Body mass index体重指数）＜30kg/m^2,择期行下腹部手术患者中施行舒芬太尼术后镇痛。随机分为2组：硬膜外镇痛组（E组）和静脉镇痛组（Ⅰ组）,比较舒芬太尼术后持续静脉输注与静脉输注的半数有效浓度及副作用。结果显示E组舒芬太尼持续硬膜外输注的EC50（median effective concentration 半数有效浓度）为0.87μg/ml,95%的可信区间为0.79μg/ml～0.96 μg/ml ;Ⅰ组舒芬太尼持续静脉输注的EC50为0.63μg/ml,95%的可信区间为0.55μg/ml～0.70μg/ml ;恶心、呕吐、皮肤瘙痒发生率两组相似,Rammsay评分Ⅰ组＞E组。因此,舒芬太尼持续静脉输注的效价大于硬膜外输注,而硬膜外输注镇痛呼吸抑制副作用更少;并推测椎管内应用舒芬太尼主要作用部位仍在脊髓以上中枢。     

晚期癌症患者静脉管理的重要性

恶性肿瘤作为我国的常见病、多发病,其死亡率高居首位。手术、化疗和放疗成为现代医疗对于癌症的常见治疗手段。中晚期癌症患者作为癌症临床诊疗对象的主体,常伴有各种慢性疾病或营养不良。从而,化疗、中药辅助巩固治疗及营养支持治疗成为中晚期癌症患者临床治疗过程中的主体。治疗方法决定给药途径,静脉输液成为了中晚期癌症患者治疗肿瘤的主...     

老年患者无痛性乳管镜检查术的优越性分析

评价无痛乳管镜检查术应用于老年高危患者的可行性、安全性。对61例合并心脑血管疾病的老年患者在丙泊酚静脉麻醉复合利多卡因表面麻醉下完成的无痛乳管镜检查术资料进行回顾性分析,统计检查成功率、患者舒适率以及不良反应发生率。结果检查成功率为100％,患者舒适率为100％,不良反应依次为呼吸抑制11例（18．03％）、血压下降7例（11．48％）、心律失常6例（9．84％）,无不良后果。丙泊酚静脉麻醉复合利多卡因表面麻醉下的无痛乳管镜检查术安全、舒适、可行,麻醉管理简单、方便,适用于合并心脑血管疾病的老年患者,值得推广应用。     

HIV/AIDS in scottish prisons: Attitudes of staff and prisoners

Abstract

Prison is commonly regarded as a high risk environment for the transmission of HIV/AIDS. Five hundred and fifty-nine prisoners and 591 prison staff sampled from 8 Scottish prisons completed questionnaires concerning attitudes towards various issues of HIVIAIDS. A majority of prisoners and prison staff expressed liberal attitudes with respect to HIV/AIDS. For both staff and prisoners, the most liberal responses were to items dealing with personal and social contact with people with HIVIAIDS. A majority of prisoners and prison staff expressed conservative attitudes in relation to screening of individuals for HIV. With regard to differences between prisoners and prison staff, prisoners were more supportive than prison staff of the provision of free condoms to homosexuals and free condoms and syringes to intravenous drug users, and the provision of free medical care to both groups in the case of AIDS. Among the prisoner sample, intravenous drug users, in comparison to non-users, were found to be more positive in their attitudes toward HIVIAIDS on a wide range of issues. The implications of the study for health psychology are discussed with regard to prisoner and prison staff educational needs and prisoner management.