Fitting cross-classification table data to models when observations are subject to classification error

Individuals are classified in a cross-classification table where two behavioral observations on each individual determine the classification. The problem is to test certain structural models assumed to underlie the cross-classified observations. A minimum chi-square test procedure is proposed.     

这不是我想象中的工作！不合规任务对新员工工作投入的影响

本研究基于情绪的认知评价理论,探讨了不合规任务对新员工工作投入的动态影响机制。通过收集分析71名新员工连续5个工作日的追踪数据发现,不合规任务会诱发新员工的不愉快情绪,进而影响其工作投入,工作成长观能够有效缓冲这一负面影响。以上结论拓宽了不合规任务的影响后果,并为如何干预不合规任务给新员工带来的消极影响提供了启示。     

死亡心理:外部防御还是内在成长?

对西方主要的死亡心理研究进行了回顾和比较分析,不同的死亡心理研究在研究传统、研究对象和研究方法方面存在差异。但是根据研究的侧重点,可以总结出死亡心理的核心内涵:外部防御和内在成长。对死亡的抽象认知产生死亡焦虑,死亡焦虑产生死亡恐惧、自我保护、外在价值导向等外部防御反应;对死亡的具体认知产生死亡反省,死亡反省产生死亡接受、亲社会动机和行为、内在价值导向等内在成长反应。作者以死亡心理的两类反应为框架,综述了近5年来新的研究证据,并对该领域当前研究的局限和未来研究方向进行了分析。     

Fibromyalgia impact and depressive symptoms: Can perceiving a silver lining make a difference?

Individuals with fibromyalgia are at greater risk for depressive symptoms than the general population, and this may be partially attributable to physical symptoms that impair day-to-day functioning. However, individual-level protective characteristics may buffer risk for psychopathology. For instance, the ability to perceive a “silver lining” in one’s illness may be related to better mental and physical health. We examined perceived silver lining as a potential moderator of the relation between fibromyalgia impact and depressive symptoms. Our sample of persons with fibromyalgia (N = 401) completed self-report measures including the Fibromyalgia Impact Questionnaire-Revised, Depression Anxiety Stress Scales, and the Silver Lining Questionnaire. Moderation analyses covaried age, sex, and ethnicity. Supporting hypotheses, increasing impact of disease was related to greater depressive symptoms, and perceptions of a silver lining attenuated that association. Despite the linkage between impairment and depressive symptoms, identifying positive aspects or outcomes of illness may reduce risk for psychopathology. Therapeutically promoting perception of a silver lining, perhaps via signature strengths exercises or a blessings journal, and encouraging cognitive reframing of the illness experience, perhaps via Motivational Interviewing or Cognitive Behavioral Therapy, may reduce depressive symptoms in persons with fibromyalgia.     

A dyadic personality perspective on the Michelangelo phenomenon: How personality traits relate to people’s ideal selves and their personal growth in romantic relationships

Personality matters for romantic relationships. In this study, we investigated personal growth in couples (the Michelangelo phenomenon) and targeted questions of personality effects. We explored whether traits intrapersonally predict ideal selves as well as whether traits intra- and interpersonally account for why some people are more likely to benefit from the Michelangelo phenomenon than others. We used data from a 4-year study of 163 couples (M_age = 50.72 years). Logistic regressions indicate complementarity effects for men, in that those high in neuroticism were likely to wish to be emotionally stable. Actor–partner interdependence models revealed positive actor effects of emotional stability, extraversion, and agreeableness, while few partner effects emerged. We discuss dyadic personal growth in view of individual trait differences.     

非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

EGFR突变NSCLC二线TKIs治疗优化选择

恶性肿瘤的治疗已经进入驱动基因指导下的个体治疗时代,肺癌患者应该进行多基因检测,特别是表皮生长因子受体（EGFR）基因突变。EGFR基因突变的非小细胞肺癌（NSCLC）患者,如果一线接受了化疗,二线应该选择表皮生长因子受体一酪氨酸酶抑制剂（EGFR—TKIs）。EGFR基因突变的NSCLC患者一线EGFR—TKIs治疗失败后,二线治疗应该是个体化合理选择,包括局部放疗、化疗和继续EGFR—TKIs。目前一代和二代EGFR—TKIs药物之间未见到显著疗效差别。第三代EGFR—TKIs是目前的EGFR—TKIs耐药后的最有希望的选择,特别是针对T790M突变耐药。