Observed behaviors during clinical interviews predict improvement in depression

A considerable percentage of depressed patients do not respond to antidepressive treatment. Early indicators of prognosis are needed. The aims of this study are to examine (a) whether the interpersonal behavior of patients and psychiatrist, as assessed by means of direct observation of behavior during a baseline clinical interview, might have predictive value with respect to therapeutic outcome and (b) which predictive potency measures of psychomotor activation, as assessed by less refined methods, such as global clinical judgment, might have. In the analysis used, speech-pause behavior was taken as the basic structure of the interaction. The relations of other behaviors such as looking and hand and head movement with this structure were determined. Evidence is presented that in a group of 31 depressives, improvement after a period of 10 weeks was related to observed behaviors during a baseline interview. The behaviors of the patients are interpreted as relational or nonrelational. The relational behaviors (i.e., looking yesnodding, gesturing) occur less in patients who will improve, whereas the nonrelational behaviors (i.e., intensive body touching, head movements) occur more in these patients. The nonrelational behaviors are presumed to be indicative of the state of arousal. The predictive potency of these variables could not be explained by their relationship with the baseline severity of depression, which in itself also predicted improvement. Moreover, global clinical assessment of psychomotor activation (i.e., retardation and agitation) could not be related to outcome.     

Anticipation across modalities in children and adults: Relating anticipatory alpha rhythm lateralization,reaction time,and executive function

The development of the ability to anticipate—as manifested by preparatory actions and neural activation related to the expectation of an upcoming stimulus—may play a key role in the ontogeny of cognitive skills more broadly. This preregistered study examined anticipatory brain potentials and behavioral responses (reaction time; RT) to anticipated target stimuli in relation to individual differences in the ability to use goals to direct action (as indexed by measures of executive function; EF). A cross-sectional investigation was conducted in 40 adults (aged 18–25 years) and 40 children (aged 6–8 years) to examine the association of changes in the amplitude of modality-specific alpha-range rhythms in the electroencephalogram (EEG) during anticipation of lateralized visual, tactile, or auditory stimuli with inter- and intraindividual variation in RT and EF. Children and adults exhibited contralateral anticipatory reductions in the mu rhythm and the visual alpha rhythm for tactile and visual anticipation, respectively, indicating modality and spatially specific attention allocation. Variability in within-subject anticipatory alpha lateralization (the difference between contralateral and ipsilateral alpha power) was related to single-trial RT. This relation was more prominent in adults than in children, and was not apparent for auditory stimuli. Multilevel models indicated that interindividual differences in anticipatory mu rhythm lateralization contributed to the significant association with variability in EF, but this was not the case for visual or auditory alpha rhythms. Exploratory microstate analyses were undertaken to cluster global field power (GFP) into a distribution-free temporal analysis examining developmental differences across samples and in relation to RT and EF. Anticipation is suggested as a developmental bridge construct connecting neuroscience, behavior, and cognition, with anticipatory EEG oscillations being discussed as quantifiable and potentially malleable indicators of stimulus prediction.     

Episodic memory effects of gamma frequency precuneus transcranial magnetic stimulation in Alzheimer's disease: A randomized multiple baseline study

Episodic memory decline is the prominent neuropsychological feature of typical Alzheimer's Disease (AD), for which current treatments have a limited clinical response. Recently, gamma entrainment therapy has been used as a non-invasive treatment in AD, providing evidence that it may have the potential to alleviate brain pathology and improve cognitive function in AD patients. At the same time, the precuneus (PC) has been recognized as a key area involved in AD related memory deficits and as a key node of the Default Mode Network. This study aimed to investigate the effectiveness of a 40 Hz Transcranial Magnetic Stimulation (TMS) intervention, delivered bilaterally to the precuneus for 10 days, in improving the patients' episodic memory performance. Secondary outcome variables investigated included general cognitive function, semantic and spatial memory, as well as attention and executive function. A concurrent multiple baseline design across five cases was employed. Four patients completed the study. Visual analysis combined with effect size indices were used to evaluate changes across phases. An increase in the average level of immediate recalled words was observed in three out of four patients. Effect size indices indicated significant improvement of attention skills in two patients. No treatment effect was observed for semantic and visual memory, or for executive function. An immediate treatment effect was observed in all patients' general cognitive function as assessed with the Alzheimer's Disease Assessment Scale (mean reduction of 5 points), which was maintained and improved further three months post-treatment. The neuropsychological evaluations indicated improved performance three months post-treatment in immediate and delayed recall, attention, phonological verbal fluency, anxiety, and neuropsychiatric symptoms. This study provides preliminary evidence for the efficacy of a novel non-pharmacological treatment using gamma-band TMS in addressing cognitive dysfunction in AD.     

DIE MARXISMUS – DEBATTE IM “SILBERNEN ZEITALTER”

Im Anfang des 20.Jahrhunderts unterzog eine Reihe von jungen, später berühmt gewordenen Philosophen den Marxismus einer tiefen Kritik. Ihnen ist es gelungen, wichtige Defekte der revolutionären Doktrinen aufzudecken und ihre verhängnivsollen Konsequenzen vorwegzunehmen. Diese Kritik ist auch für die gegenwärtige geistig-politische Situation aktuell.     

Apocalyptic Argument and the Anticipation of Catastrophe: the Prediction of Risk and the Risks of Prediction

This essay proposes to extend the model of apocalyptic argument developedin my recent book Arguing the Apocalypse (OLeary, 1994) beyond the study ofreligious discourse, by applying this model to the debate over awell-publicized earthquake prediction that caused a widespread panic in theAmerican midwest in December, 1990. The first section of the essay willsummarize the essential elements of apocalyptic argument as I have earlierdefined them; the second section will apply the model to the case of the NewMadrid, Missouri, earthquake prediction, in order to demonstrate thatcertain patterns of reasoning characteristic of religious apocalyptic arepresent in the discourse over an anticipated local disaster. My ultimatepurpose is to show that predictions of global and local catastrophe mayserve as extreme cases that will illuminate the dynamics of predictiveargument in general. Thus my argument will seek to undercut Daniel Bellsdistinction between prophecy and prediction (Bell, 1973) by establishingthat these discourses share identifiable formal and substantivecharacteristics, and depend for their rhetorical effect on anxiety, hope,far, and excitement as modes of temporal anticipation.     

Antecedents of information-processing skills in infants: Habituation, novelty responsiveness, and cross-modal transfer

Three skills which characterize cognitive functioning in human infants in the middle of the first year of life—habituation, novelty responsiveness, and cross-modal transfer—predict mental ability in later childhood. Antecedents of each skill at 5 months postnatal were examined in a short-term prospective longitudinal study of infant ability and maternal intelligence and interaction style. Infant perceptuocognitive performance at 2 months, maternal intelligence, and maternal responsiveness at 5 months relate to the expression of the three infant cognitive skills, but in different ways. Variation in infant information-processing abilities can be explained by specific child and maternal factors that are evident soon after birth.     

Correlation and prediction in ordinal test theory

Based on the test theory model for ordinal measurements proposed by Schulman and Haden, the present paper considers correlations between tests, attenuation, regressions involving true and observed scores, and prediction of test reliability.The population correlation between tests is shown to be related to the expected sample correlation for samples of sizen ₁ andn ₂. Errors of estimation, measurement and prediction are found to be similar to their counterparts in interval test theory, while attenuation is identical to its counterpart. The bias in estimating population reliability from sample data is compared for Kendall's tau and Spearman's rho.The author wishes to thank the referees for their helpful comments on an earlier draft of this paper, and in particular, for the suggested alternative methods of establishing some of the presented results.     

Changes in Children's Episodic Narratives Through Long-Term Repeated Recall: Longitudinal Case Studies1

This study aimed to investigate whether a child's narrative of a particular past episode would change in repeated reporting over the long term, and if so, how it would change. To answer these questions, I conducted longitudinal case studies of episodic reports by children every 2–6 months, from their early childhood to the age of 10–15 years. Criteria for inclusion were set in advance; seven episodic narratives meeting these criteria were analyzed. Two types of changes in the narratives were observed, as expected: that of including other information, and that of an event suddenly being reported after no recall for several years. Information from the children's surroundings seemed to be substantially involved in these changes in their episodic narratives. The present results also indicate that mothers' episodic memories are not always reliable and that the schema children have can influence their episodic memories.     

物体颜色对情景记忆的影响

本研究采用ERP技术和学习-再认范式考察视觉输入的颜色和记忆中的物体颜色知识一致性对情景记忆编码和提取的影响。结果显示, 在对物体图片进行编码时颜色不一致图片诱发更大N400, 而提取阶段则对颜色一致图片有更多熟悉性加工(实验1); 物体名称能够更快激活典型颜色知识, 对颜色一致名称有更多细节回想(LPC更正) (实验2)。实验结果表明, 颜色一致促进知觉水平的记忆编码, 而阻碍语义水平编码。同时, 颜色一致促进物体图片提取(知觉水平)中的熟悉性和回想过程; 而对物体名称提取(概念水平)的促进作用仅表现在回想上。此外, 颜色与物体名称有着密切联系, 同样影响物体的语义表征, 支持激活-扩散模型理论。本研究从知觉和概念水平上为揭示物体颜色在联结记忆中的作用提供了证据。     

心理因素与学业表现：机器学习分类预测模型

随着高等教育规模的扩大,学业表现不良逐渐成为一个不容忽视的现象,对学业表现不良的学生进行预测并提早给予干预可降低退学率并减少教育资源的损失。由于导致学业表现不良的因素众多且关系复杂,传统的基于相关分析的研究方法很难建立早期预测模型并进行应用。本研究旨在利用机器学习算法,对数据进行挖掘,并建立学业表现预测模型。研究对653名大一新生的心理健康状况、应对方式、人格、内外控倾向和相关人口统计学信息进行了收集,并在一年后采集了其学业成绩,利用随机森林(RF)、K邻近（KNN）、支持向量机（SVM）、决策树（DT）、朴素贝叶斯（NB）等机器学习算法建立了分类模型。结果显示,随机森林算法在识别学业表现不良学生时有最好的表现,其中准确率95.86%, 召回率91.83%,f1分数为93.80%。特征重要性分析显示,前10个对模型有最高贡献度的特征包括：年龄、性别、是否为独生子、内外控倾向、神经质倾向、积极应对倾向、宜人性倾向、一般症状指数、开放性倾向和焦虑水平。为避免过度拟合问题,本研究在一年后收集的166名新生样本中进行了模型验证,结果显示模型在新数据集上有较好的泛化表现,其中f1分数90.90％,准确率92.60％,召回率89.26％。研究提示基于人口统计学和心理测评信息,机器学习算法有助于及早识别学业表现不良学生并为开展早期干预提供启示。