TRACING A TRAJECTORY

Abstract. Theology and ethics intersect with sciences at different points depending upon whether the scholars involved are interested in, for example, general epistemological issues or practical moral judgments. The intersection affects theology and ethics in different ways, depending upon various commitments or resistances on the part of theologians. The author surveys his own writings to show how openness to the sciences has had an impact on various phases of his work and what issues remain somewhat unresolved.     

Non-empirical and empirical components in the hypotheses of five social psychological experiments

Five studies published in the Journal of Experimental Social Psychology and selected without advance knowledge of their contents, were analyzed with respect to the epistemic and modal status of their hypotheses. It was found that the general hypotheses were a priori and noncontingent (necessarily true), whereas the local auxiliary hypotheses were empirical and contingent. Hence, the data were only relevant for the latter. It is conjectured that such pseudoempirical studies may abound in contemporary psychology. They remain undiscovered because researchers unreflectively believe that all propositions that can be related to data are empirical and that psychological terms need not be defined. Only when terms are defined and presuppositions (axioms) are stated, can one determine the epistemic and modal status of a given proposition, and, hence, whether or not a study is pseudoempirical.     

Therapeutic Relationship

This article addresses the important role of the therapeutic relationship in cognitive-behavioral therapy (CBT). As has been noted from the inception of CBT, there are critical features of both the therapist and the relationship that optimize the likelihood of therapeutic success, and this article briefly describes these features. It is further argued that a successful therapeutic relationship in CBT is not static but is flexible and adaptive both across and within clients, as their needs and concerns vary. A positive therapeutic relationship is viewed within CBT as a necessary but insufficient condition for change, as the relationship serves as a foundation upon which interventions are scaffolded, but that the client’s response to various interventions itself shapes the interactions between therapist and client. Finally, it is argued that the key therapeutic ingredients of CBT are largely teachable, and the article provides several suggestions to promote an effective therapeutic relationship in CBT.     

MIRACLES AND TWO ACCOUNTS OF SCIENTIFIC LAWS

Since early modernity, it has often been assumed that miracles are incompatible with the existence of the natural laws utilized in the sciences. This paper argues that this assumption is largely an artifact of empiricist accounts of laws that should be rejected for reasons internal to philosophy of science, and that no such incompatibility arises on the most important alternative interpretations, which treat laws as expressions of forces, dispositions, or causal powers.     

AMAs及其靶抗原在原发性胆汁性肝硬化发病中的作用

原发性胆汁性肝硬化（PBC）是一种以慢性进行性胆汁淤积为特点的自身免疫性肝病,血清中抗线粒体抗体（AMAs）,尤其AMA-M2升高是该病的特异性表现.AMAs在PBC发病过程中的作用是研究重点之一.丙酮酸脱氢酶复合物（PDC）的E2亚单位（PDC-E2）是AMAs的主要抗原.诱发AMAs靶抗原暴露和打破免疫耐受的主要诱因是感染及化学因素.后者或与靶抗原交叉反应,或通过对靶抗原的化学修饰,或是使凋亡后抗原的清除发生障碍,从而促进AMAs的产生.针对PDC-E2的细胞免疫主要参与PBC的发病.AMAs在PBC发病中的作用存在争议,更多研究认为其不参与PBC的发病.     

自身免疫性胰腺炎的诊治进展

自身免疫性胰腺炎（AIP）是一种特殊类型的慢性胰腺炎,以胰腺肿大及胰管不规则狭窄为特征.AIP分两个亚型：Ⅰ型AIP好发于亚洲老年人,为淋巴浆细胞硬化性胰腺炎;Ⅱ型AIP多见于西方人,为导管中心型胰腺炎.AIP缺乏特异性血清标志物,诊断主要依赖于其特征性改变.依据AIP诊断标准国际共识,AIP的诊断包括影像学、血清学、胰腺外器官受累、组织病理学和诊断性激素治疗5个方面.糖皮质激素是AIP的首选治疗方法,但复发率高,免疫调节剂对维持AIP的持续缓解具有一定作用.AIP总体预后良好,胰管结石和癌变是其潜在的并发症,但发生率极低.     

Zuckerkandl结节在甲状腺手术中对上甲状旁腺的定位与保护

探讨Zuckerkandl结节（ZT）在甲状腺手术中对上甲状旁腺的定位与保护作用.对我院2011年10月至2013年1月在我院行甲状腺手术患者351例进行回顾分析,结果显示,ZT在左侧叶甲状腺的发生率为89.0％（268/301）,右侧叶中的发生率为87.3％（254/291）,共计5例患者出现术后甲状旁腺功能一过性下降,未有永久性甲状旁腺功能损失患者出现.ZT为甲状腺手术中探查上甲状旁腺提供了新的途径与解剖标志,值得引起甲状腺外科医生的关注.     

CXCR4和CXCR7在甲状腺癌中的表达及病理意义

研究甲状腺癌组织中趋化因子4受体（CXCR4）和趋化因子7受体（CXCR7）的表达情况及临床病理意义。应用免疫组织化学PV-6000法及Westernblot法检测CXCR4与CXCR7在甲状腺癌中的表达。二者在甲状腺癌与甲状腺良性疾病组织的差异均具有统计学意义（P〈0．05）,在甲状腺癌中表达仅与淋巴结转移有关（P〈0．05）,CXCR4与CXCR7之间呈正相关。Westernblot结果提示二者在甲状腺癌中的表达率高于癌旁及甲状腺腺瘤。CXCR4和CXCR7的表达水平与淋巴结转移相关,可作为甲状腺癌预后的判断指标。