AC loss density component in electrical steel sheets

This article proposes a new approach to the loss separation issue. The conventional loss separation into three components is abandoned. The dependence of the dynamic component of loss density versus frequency is assumed to be a power law. The model is verified for selected samples of nonoriented and grain-oriented steel.     

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

The perforant path projecting from the entorhinal cortex to the hippocampal dentate gyrus is a particularly vulnerable target to the early deposition of amyloid beta (Abeta) peptides in Alzheimer's brain. The authors previously showed that brief applications of Abeta at subneurotoxic concentrations suppressed the early-phase long-term potentiation (E-LTP) in rat dentate gyrus. The current study further examines the effect of Abeta on the late-phase LTP (L-LTP) in this area. Using multiple high-frequency stimulus trains, a stable L-LTP lasting for at least 3 h was induced in the medial perforant path of rat hippocampal slices. Bath application of Abeta(1-42) (0.2-1.0 microM) during the induction trains attenuated both the initial and late stages of L-LTP. On the other hand, Abeta(1-42) perfusion within the first hour following the induction primarily impaired the late stage of L-LTP, which resembled the action of the protein synthesis inhibitor emetine. Blockade of calcineurin activity with FK506 or cyclosporin A completely prevented Abeta-induced L-LTP deficits. These results suggest that Abeta(1-42) impaired both the induction and maintenance phase of dentate L-LTP through calcineurin-dependent mechanisms. In the concentration range effective for inhibiting L-LTP, Abeta(1-42) also reduced the amplitude of NMDA receptor-mediated synaptic currents in dentate granule cells via a postsynaptic mechanism. In addition, concurrent applications of Abeta(1-42) with the protein synthesis inhibitor caused no additive reduction of L-LTP, indicating a common mechanism underlying the action of both. Thus, inhibition of NMDA receptor channels and disruption of protein synthesis were two possible mechanisms contributing to Abeta-induced L-LTP impairment.     

Philosophy in Post-Soviet Russia (1992--1997)

The author argues that the decline of philosophical thought and research in Russia is over. He describes the state of present-day philosophy in Russia, its background, and prospects for development citing concrete examples and little known facts.Any survey of the state of the philosophy in post-Communist Russia is a complicated task requiring accuracy and completness. Whether I succeed in this task remains to be seen, although I shall be content if I manage to present a clear picture. It will of course be subjective and reflect my interests and preferences, remaining in this sense quite incomplete. But I aim to present a concise survey, identifying the most important trends, personalities, and topics of discussion.I shall focus on changes with respect to the following issues: 1) the state of research in philosophy, in particular noticeable shifts in problematics, geography, and management; 2) philosophical education, i.e., noticeable development in problematics, approaches, geography, and management. Moreover, I shall examine the origin of these shifts and assess whether they are of a qualitative character.