门静脉血流改变对晚期高位胆管癌的诊断价值

通过探讨正常人与高位胆管癌病人之间的门静脉血流改变,发现两者之间有明显的不同。所以门静脉血流改变在诊断高位胆管癌方面具有重要意义。     

Estimation of indifference points with an adjusting-delay procedure.

In a series of conditions, pigeons chose between 1.5 s and 3 s of access to grain, each preceded by some delay. The delay that preceded the small reinforcer was constant throughout a condition. The delay that preceded the large reinforcer was increased or decreased a number of times each session in order to estimate an "indifference point," a delay at which the subject chose each alternative about equally often. The experiment was designed to determine whether variations in any of four features of this adjusting-delay procedure would systematically alter the estimated indifference points. The four features were the total trial duration, the number of center-key responses necessary to begin a trial, the number of choice trials that preceded each change in the adjusting delay, and step size--the size of each increment and decrement in the delay. Manipulation of the first three features had no systematic effects on the indifference points. As step size was increased from 0.5 s to 6 s, within-session variability of the adjusting delay steadily increased, and the 6-s step size produced larger indifference-point estimates for some subjects. The results suggest that, within certain limits, these procedural features can be altered without affecting the indifference-point estimates, but that the use of a large step size can distort the estimates. Some theoretical implications of the relative constancy of indifference points across these procedural variations are discussed.     

MAINTAINING PERFORMANCE OF AUTISTIC CLIENTS IN COMMUNITY SETTINGS WITH DELAYED CONTINGENCIES

To facilitate the classroom and workshop integration of three autistic clients, we examined the feasibility of teaching them to respond appropriately without the continual presence of specially trained treatment providers. Within a multiple baseline design, a 4-step treatment process was implemented to promote durable responsive performance. Results indicated that the therapist could be removed from the treatment environment and that appropriate behavior could be successfully maintained in community settings with only infrequent and delayed contingencies.     

Delayed temporal discrimination in pigeons: A comparison of two procedures

A within-subjects comparison was made of pigeons' performance on two temporal discrimination procedures that were signaled by differently colored keylight samples. During stimulus trials, a peck on the key displaying a slanted line was reinforced following short keylight samples, and a peck on the key displaying a horizontal line was reinforced following long keylight samples, regardless of the location of the stimuli on those two choice keys. During position trials, a peck on the left key was reinforced following short keylight samples and a peck on the right key was reinforced following long keylight samples, regardless of which line stimulus appeared on the correct key. Thus, on stimulus trials, the correct choice key could not be discriminated prior to the presentation of the test stimuli, whereas on position trials, the correct choice key could be discriminated during the presentation of the sample stimulus. During Phase 1, with a 0-s delay between sample and choice stimuli, discrimination learning was faster on position trials than on stimulus trials for all 4 birds. During Phase 2, 0-, 0.5-, and 1.0-s delays produced differential loss of stimulus control under the two tasks for 2 birds. Response patterns during the delay intervals provided some evidence for differential mediation of the two delayed discriminations. These between-task differences suggest that the same processes may not mediate performance in each.     

DOES EFFORT PLAY A ROLE IN THE EFFECT OF RESPONSE REQUIREMENTS ON DELAYED MATCHING TO SAMPLE?

The possible role of "effort" in the accuracy of pigeons' performance on a delayed matching-to-sample procedure was investigated by examining the effects of response requirements that accompanied a trial-initiating stimulus and that accompanied a sample stimulus. In the first experiment, the effect of varying the size of a fixed-ratio requirement for responses during an initiating stimulus was compared to that of varying a similar requirement for responses during the sample stimulus. Accuracy increased reliably with increases in the ratio scheduled during the sample stimulus, but was not significantly affected by increases in the ratio scheduled on the key during the initiating stimulus. In another phase of Experiment 1, sample duration was held constant while the ratio requirement was varied during the initiating stimulus. Again, accuracy of matching to sample was not significantly affected by the size of the ratio scheduled during the initiating stimulus. Experiment 2 provided a systematic replication of these results in another group of pigeons and included a more detailed analysis of responding. These results support the view that increases in sample-response requirement facilitate accuracy of delayed matching by increasing the durations of exposure to the sample stimuli, and do not support a role of effort in the sample-response effect. In Experiment 3, the facilitative effect of responses on the sample but not of those on the initiating stimulus was replicated using a simultaneous matching-to-sample procedure. This finding provides further evidence against an interpretation of response-requirement effects that appeals to effort; the finding also suggests that sample exposure might affect initial discrimination of the sample rather than remembering the sample.     

Delayed reinforcement as an indiscriminable contingency in verbal/nonverbal correspondence training

We investigated the programming of generalization and maintenance of correspondence between verbal and nonverbal behavior in a preschool setting. Four children participated in a series of multiple-baseline designs. In Experiment 1, delayed reinforcement of verbal behavior effectively controlled maintenance of correspondence with previously trained responses and also resulted in generalization of correspondence to one untrained response. As the latter effect was limited, Experiment 2 was a further assessment of the effects of delayed reinforcement of generalization of correspondence to untrained responses, and consistent generalization was shown. Experiment 2 also showed that generalization, if lost, could be recovered through use of "booster training," in which the original contingencies were reinstated for a brief period. Experiment 3 provided replications, with two additional children, of the effects of delayed reinforcement on maintenance of correspondence. Results are discussed in terms of using delayed reinforcement as an indiscriminable contingency.     

Issues in diagnosing anxiety disorders

Research progress in the anxiety disorders is predicated on a useful classification system. In this paper, we review the reliability and validity data for theDiagnostic and Statistical Manual of Mental Disorders, 3rd ed. (DSM-III) anxiety disorders and discuss the salient issues associated with both the conceptualization of anxiety disorders and the diagnostic criteria offered in the DSM-III. It is concluded that the diagnostic reliability for these disorders is, overall, satisfactory. A dearth of validity data, however, hinders progress in both the diagnosis and the treatment of the anxiety disorders. Nevertheless, the DSM-III work group has proposed several changes in the diagnostic criteria for the anxiety disorders. We find some of these proposed changes helpful in that they clarify current diagnostic criteria; changes in diagnostic criteria that alter the basic classification schema, however, seem to be premature.Preparation of this paper was supported in part by MIMH Research Grant 1368.On sabbatical leave from Indiana State University.     

Offering predictive testing for Huntington disease in a medical genetics clinic: Practical applications

Predictive testing for Huntington disease is presently offered in a select few medical genetics centers in the United States. This is in part due to the labor intensive counseling and psychological testing suggested by the research protocols. We discuss some specific suggestions for establishing programs for Huntington disease predictive testing within pre-existing medical genetics clinics to encourage more centers to offer presymptomatic testing. This will allow more at risk individuals the opportunity to consider predictive testing and cut down the expenses of traveling to the few predictive testing centers that currently exist. The counseling principals will remain similar to those discussed here, even following the identification of the Huntington disease mutation.     

Delayed and current stimulus control in successive discriminations

In a successive discrimination in which successively alternating red and green hues signaled component variable-interval schedules, sensitivity of the ratio of responses in the two components to variation in the component reinforcer ratio decreased systematically during the course of the component. This decrease in stimulus control or discrimination over the course of the component was shown to be the result of delayed control of responding during the component by the stimulus transition between components. When the red–green stimulus transition was altered by interpolating a white stimulus at the end of each 60-s component, discrimination at the beginning of the component (measured by the power-function exponent for sensitivity to reinforcement) was reduced. Conditions with the white stimulus inserted in other quarters of the component indicated that the current discriminative stimulus exerts control over responding throughout the component, whereas during about the first half of the component, response differentials are influenced by the transition between discriminative stimuli.     

Unification of models for choice between delayed reinforcers.

Two models for choice between delayed reinforcers, Fantino's delay-reduction theory and Killeen's incentive theory, are reviewed. Incentive theory is amended to incorporate the effects of arousal on alternate types of behavior that might block the reinforcement of the target behavior. This amended version is shown to differ from the delay-reduction theory in a term that is an exponential in incentive theory and a difference in delay-reduction theory. A power series approximation to the exponential generates a model that is formally identical with delay-reduction theory. Correlations between delay-reduction theory and the amended incentive theory show excellent congruence over a range of experimental conditions. Although the assumptions that gave rise to delay-reduction theory and incentive theory remain different and testable, the models deriving from the theories are unlikely to be discriminable by parametric experimental tests. This congruence of the models is recognized by naming the common model the delayed reinforcement model, which is then compared with other models of choice such as Killeen and Fetterman's (1988) behavioral theory of timing, Mazur's (1984) equivalence rule, and Vaughan's (1985) melioration theory.