逆行性肾盂造影联合输尿管软镜在诊断小肾盏癌中的价值

探讨逆行性肾盂造影联合输尿管软镜在诊断小肾盏癌中的价值。回顾分析5例小肾盏癌临床资料,术后病理检查结果均提示尿路上皮癌I级（Ta-G1）,术后定期行膀胱内灌注化疗药物,且均未出现肿瘤其他部位转移等并发症发生。对5例患者均进行随访,1年期间每3个月行尿常规及B超检查均正常,1年生存率达100％。患者出现血尿症状,虽然常规检查（尿常规、B超、IVU、CT或MRI等）诊断不明确者,都可行逆行性肾盂造影检查。一旦逆行性肾盂造影检查提示异常图像,均可提示肾盏癌,使误诊率及漏诊率降至最低程度,尽可能阻断早期肿瘤的发展。故逆行性肾孟造影联合输尿管软镜可提高早期小肾盏癌的术前诊断率。     

IGFBP-2及IGFBP-6在结直肠癌中的表达及意义

研究胰岛素样生长因子结合蛋白2（IGFBP-2）及胰岛素样生长因子结合蛋白6（IGFBP-6）在结直肠癌中的表达及临床意义。采用免疫组织化学法及RT-PCR方法检测结直肠癌、结直肠腺瘤及癌旁正常黏膜组织中IGFBP-2及IGFBP-6的蛋白及mRNA的表达情况,结合临床病理资料进行统计学分析。IGFBP-2及IGFBP-6蛋白的阳性表达及mRNA的表达量在三组组织中均存在异常表达情况,且差异有明显的统计学意义（P〈0.05）,在结直肠癌组IGFBP-2、IGFBP-6的阳性表达在肿瘤浸润深度、有无淋巴结转移及Duke＇s分期存在差异,有明显的统计学差异（P〈0.05）。临床可以把二者作为结直肠癌诊断及预后的早期预测指标。     

Determination of problems in patients with post‐laryngectomy

The purpose of this study is the determination of the physical and psychosocial problems of total and partial laryngectomies. A total of 25 patients, who were operated with the diagnosis of larynx carcinoma in 2010 at Gazi University Faculty of Medicine Otolaryngology Department, were included in the study. They were evaluated with the help of the Personal Information Form (PIF) and the Determination Form of Post Laryngectomy Problem (DFPLP) for the problems they encountered after the operation. Total laryngectomy (TL) was performed on 76% of patients. It was determined that patients undergoing total laryngectomy experienced some physical and psycho‐social problems such as problems in sleep (31.6%), smell (52.6%), taste (36.8%), and difficulty in swallowing solid foods (36.8%). Furthermore in patients with TL surgery whilst 47.4% of them think that their sexual lives were affected rather negatively, this rate was determined as 33.3% in patients with partial laryngectomy surgery (PL). The psychosocial score averages of the patients who had smell and taste disorders were significantly lower (p < 0.05). The patients, who underwent a laryngectomy operation, experienced many physical, social, and psychological problems. Thus, medical personnel also need to pay attention to these concomitant problems that occur during the treatment of the primary disease and the application of necessary supplementary treatments such as voice prosthesis, pre‐op and post‐op counseling, and anti‐depressants seems significant in terms of increasing the life quality of the patients.     

A pilot evaluation of the efficacy of a couple-tailored print intervention on colorectal cancer screening practices among non-adherent couples

The objective of this study was to evaluate the efficacy of a couple-tailored print (CTP) intervention on colorectal cancer screening (CRCS), CRCS intentions, and on knowledge and attitudes among couples in which neither partner is on schedule with regard to CRCS. A total of 168 married couples with both members non-adherent with CRCS were randomly assigned to receive either a CTP pamphlet accompanied by a generic print (GP) pamphlet or a GP pamphlet only. Couples completed measures of CRCS, intentions, relational perspective on CRCS, discussions about CRCS, spouse support for CRCS, spouse influence strategies, CRC knowledge, perceived CRC risk, and CRCS benefits and barriers. Results indicated there was no significant benefit of CTP vs. GP on CRCS, but there was a significant increase in CRCS intentions in CTP compared with GP. There was also a significant increase in relationship perspective on CRCS, a significant increase in husbands’ support of their wives’ CRCS, and a significant increase in CRCS benefits in CTP. In summary, CTP did not increase CRCS practices but increased intentions and perceived benefits of CRCS as well as improving couples’ ability to view CRCS as having benefit for the marital relationship.     

食管癌切除术后颈部不同方法食管胃吻合比较分析

比较食管癌切除术后应用非一次性沪产吻合器和手工缝合在颈部行食管胃吻合的经验体会。我科1998年11月~2010年12月,食管癌切除术后应用沪产吻合器在颈部通过＂反插法＂进行食管胃吻合126例;手工缝合100例。结果全部病例均治愈出院,手工缝合组发生吻合口瘘5例,吻合口狭窄9例,食物返流18例,吻合口出血1例;吻合器组未...     

乙酰肝素酶剪接变体T5mRNA在肾癌中的表达

探讨乙酰肝素酶（Hpa）剪接变体T5mRNA在肾癌（RCC）组织中的表达,分析其与RCC发生发展及预后的关系。采用逆转录-聚合酶链反应（半定量RT—PCR）方法检测RCC组织标本及癌旁正常组织标本中T5mRNA的表达。结果RCC组织中T5mRNA阳性率高于癌旁正常组织（P〈0．05）;T5mRNA阳性表达率与RCC病理...     

肝癌基础研究如何向临床转化

肝癌基础研究在过去数十年取得了长足的进步,而肝癌临床研究则相对滞后,二者间存在巨大的反差。如何将基因组时代发现的大量有重要意义的基础研究成果及时有效地转化为临床可用的技术方法,以进一步提高肝癌治疗效果是亟待解决的难题。转化医学研究为其搭建了一条重要桥梁。     

低位直肠癌保肛手术的哲学思辨

回顾直肠癌手术的发展史,追求根治与功能相互对立统一的发展过程。低位直肠癌保肛手术经历了长时间的对立、演化、发展,如今已经不再是手术技巧的问题,而是如何掌握保肛原则的问题。只有树立辩证唯物主义的世界观和方法论并用于实践,才能有助于进一步提高直肠癌的手术疗效。     

甲状腺癌的诊治原则

甲状腺癌是内分泌系统最常见的恶性肿瘤,它的发病率正逐年增加,其诊断方法包括体格检查、超声检查、细针穿刺、影像学检查及实验室检查等,甲状腺癌的治疗以外科手术为主,对较晚期或远处转移的患者可行综合治疗(I131,放疗,化疗)。总之,甲状腺癌经合理治疗,可获得较好的预后。     

早期宫颈癌术式选择的比较研究

根治性子宫切除术与保留生育功能的根治性宫颈切除术均可用于早期宫颈癌患者的手术治疗。根据生物-心理-社会医学模式的要求,本文采用比较治疗学的方法,对这两种手术方式,从适应证、手术方式、并发症、疗效等方面进行比较,为宫颈癌临床科学决策提供借鉴。