Effects of midbrain central gray lesions on spontaneous and electrically induced aggression in the rat

Large electrolytic lesions were placed in the midbrain central gray of male rats. Their effects on hypothalamically induced aggression, switch-off behaviour, and locomotion were investigated. A number of these animals were also tested for territorial intermale aggression in order to compare electrically induced and spontaneous aggression. Large lesions resulted in an increase of the current threshold to induce aggression by hypo-thalamic stimulation. Smaller, but still quite large, lesions decreased the threshold current for hypothalamic aggression. After the operation a decrease in the threshold for switch-off was present, both in the experimental and the control group. Current thresholds for locomotion were decreased after the lesions only in the experimental group. Spontaneous aggression was temporarily decreased after the lesion. No indication was found that other behavioural elements of the animal were distorted by the lesion. The parallel between the effects on spontaneous and electrically induced aggression makes it attractive to ascribe a role to the neural circuit of hypothalamus and central gray in territorial aggression. However, even with large lesions the animals were still capable of fighting, hence the central gray is not indispensable. An attempt was made to explain the differential effects that differently sized central gray lesions have on hypothalamic aggression.     

The neural pathways mediating quiet-biting attack behavior from the hypothalamus in the cat: A functional autoradiographic study

Electrical stimulation of the region of the lateral hypothalamus produced a consistent form of quiet-biting attack behavior in cats. In one series of experiments, cats, implanted with electrodes from which attack had been elicited, were anesthetized and then were injected with a bolus of ¹⁴C-2-deoxyglucose at the same time as electrical stimulation was delivered through the attack electrodes. Brains prepared for X-ray autoradiography revealed that lateral hypothalamic stimulation activated the classical medial forebrain bundle pathway supplying the septal region, diagonal band, lateral preoptic area, and ventral tegmental region. Stimulation of quiet-attack sites in perifornical hypothalamus resulted in the activation of a much more extensive projection system which included the central and lateral tegmental fields of the midbrain and pons, and central gray region, as well as the structures described above. In a second series of experiments, ³H-leucine was placed into the region of the electrode tip from which attack was elicited in order to identify more precisely the pathways arising from that site. In general, tritiated amino acid radioautography replicated the ¹⁴C-2-deoxyglucose findings. In addition, the amino acid radioautographic data revealed the presence of extensive projections from perifornical hypothalamus to such pontine structures as the nucleus locus coeruleus, motor nucleus of NV , and the lateral pontine tegmental field. The functional connections between the lateral hypothalamic “attack region” and lateral preoptic zone were also confirmed by electrophysiological methods.     

Dopamine regulation of human speech and bird song: a critical review

To understand the neural basis of human speech control, extensive research has been done using a variety of methodologies in a range of experimental models. Nevertheless, several critical questions about learned vocal motor control still remain open. One of them is the mechanism(s) by which neurotransmitters, such as dopamine, modulate speech and song production. In this review, we bring together the two fields of investigations of dopamine action on voice control in humans and songbirds, who share similar behavioral and neural mechanisms for speech and song production. While human studies investigating the role of dopamine in speech control are limited to reports in neurological patients, research on dopaminergic modulation of bird song control has recently expanded our views on how this system might be organized. We discuss the parallels between bird song and human speech from the perspective of dopaminergic control as well as outline important differences between these species.     

Prevalence and correlates of metabolic syndrome in Hong Kong Chinese adults—a random community sample study

The study investigates the prevalence and correlates of metabolic syndrome (MS) among Hong Kong Chinese adults. Random cluster sampling design and International Diabetes Federation (IDF) MS criteria were adopted. Totally 737 adults participated in questionnaire survey and received waist circumference (WC) measurement. Among them 335 showed central obesity (WC > 80 and 85 cm for women and men respectively). Subsequently 229 accepted blood test. Totally 71 participants met MS criteria, suggesting an overall prevalence of 14.1%. Both central obesity and MS increase sharply with age. Chi-square/ANOVA analyses revealed significant positive associations between central obesity with: being male, marital status being married/cohabit, lower education level, occupation as managers or housewives, and alcohol consumption. For MS, the significant positive correlates were: lower education level, occupation as service workers or housewives, lower income level, and alcohol consumption. After controlling for age, binary logistic regression analyses suggested the significant risk factors for central obesity were being male (OR = 1.4), married/cohabit (OR = 1.8), longer working hours (OR = 1.5), eating less vegetables (OR = 1.5), and alcohol consumption (OR = 1.8). For MS, only alcohol consumption appeared to be a significant risk factor (OR = 2.3). Multivariate binary logistic regressions also supported that age group and alcohol consumption were significant predictors of MS. To conclude, adopting randomized cluster sampling and IDF criteria, the study revealed a prevalence rate of MS at 14.1%. Alcohol consumption appears to be the strongest risk factor of MS, which however needs further investigation.     

空间工作记忆负载对中央注视线索返回抑制的影响

通过两个实验,探讨空间工作记忆负载对中央注视线索引发返回抑制（inhibition of return,IOR）的影响。实验一通过再认面孔的相似度来控制与中央注视线索相关的空间工作记忆任务负载,结果发现,高任务负载条件下出现IOR,低任务负载条件下中央注视线索促进搜索;实验二在实验一高任务负载的基础上加入与注视线索无关的空间工作记忆任务,结果发现,仅在与注视线索无关的空间工作记忆负载低的条件下出现IOR。结果表明,中央注视线索引发的IOR受到空间工作记忆资源的限制,中央注视线索只有在获得足够的资源时才能引发IOR。注视线索获得空间工作记忆资源多少决定中央注视线索能否引发IOR。     

Los niveles de análisis de la emoción: James,cien años después

RESUMEN

En este artículo se analizan las implicaciones de la teoría de James con un siglo de perspectiva y, se realiza un amplio estudio de la noción de emoción y su significación psicológica y epistemológica. Se exponen los principios fundamentales de la Teoría de James-Lange, además de exponer la teoría de Canon que se enfrentaba a la Teoría de James-Lange, se recogen también, aquellas teorías que se sitúan en un punto intermedio de estas dos teorías. Finalmente se analiza en mayor profundidad la teoría de James en la actualidad y sus implicaciones epistemológicas.     

The Theory Of Social–Cultural Genetic Gene (S- c Dna)

It took a long time for humanity to know about biogenetics. And yet its role as a determinant in the living system was not proven until the twentieth century when DNA was discovered. Similarly, it took a long time for humanity to know about culture and civilization. And yet until now there is neither definite standards for differentiating them nor a definition that is commonly acceptable. By taking an evolutionary pluralism as ontology framework and the transdisciplinary research method of the systems science, we have in the new social system model discovered the central rules that govern the social–cultural heredity: Culture–Production–Civilization. The relationship between culture and civilization is exactly that of genotype and phenotype. Culture is the S-cDNA within the social system while civilization is the social phenotype. Culture is a determinant that ultimately determines the existence, stagnation, change, and evolution of the social system.     

奖赏环路与阿片成瘾:喙内侧被盖核的调节作用

喙内侧被盖核(RMTg)位于腹侧被盖区(VTA)的尾部, 富含抑制性的γ-氨基丁酸(GABA)能神经元.RMTg是中脑边缘多巴胺系统的一个综合调节器.它的GABA能神经元接受外侧缰核(LHb)的输入, 然后投射到VTA多巴胺能神经元, 进而抑制多巴胺的释放.这三个脑区是奖赏环路的重要组成部分, 其中RMTg在阿片类物质激活的奖赏环路中尤为重要.阿片类物质主要通过抑制RMTg GABA能神经元使VTA多巴胺能神经元去抑制, 进而激活奖赏系统.因此, RMTg有望成为治疗药物成瘾(尤其是阿片成瘾)的一个重要靶点.此外, 胆碱类物质作用于RMTg的毒蕈碱受体能够抑制阿片类物质诱导的奖赏效应.未来研究应深入探讨RMTg调控的负性奖赏环路, 这对弱化觅药动机,促进消退和戒断具有重要意义.     

工作记忆成分的年龄相关差异对算术策略运用的预测效应

采用选择/无选范式,借助工作记忆成套测验,在两位数乘法估算问题中探讨了工作记忆系统各成分对不同年龄段个体算术策略运用的预测效应。结果显示:(1)工作记忆的不同成分与年龄之间存在明显的相关。表现为,除视空模板成分外,其他各成分得分随着年龄增长而呈现上升趋势;(2)估算策略运用中,年龄与策略选择显著相关,表现为随着年龄增长,策略选择表现明显提高;(3)估算策略运用中,不同年龄个体的工作记忆不同成分和策略选择表现出不同的联系,中央执行均显示出显著的预测效应,语音环路和视空模板的预测效应均不显著。不同年龄个体的工作记忆不同成分对策略执行的预测效应均不显著。上述发现对于深刻理解工作记忆系统在算术认知策略运用中的作用机制具有重要理论含义。     

文本阅读中概念提取的研究进展

文章对文本阅读中概念提取的研究进行了系统的介绍,虽然研究者得出了不同的结论,但都力图揭示文本阅读中概念提取的信息加工机制。文章在此基础上对影响文本阅读中概念提取的因素进行初步分析．发现文本类型、文本中心确定方式和抑制是主要因素。其中,文本中心确定方式是最主要的影响因素。