Synapses,Schizophrenia, and Civilization: What Made Homo Sapient?

Progress in technology has allowed dynamic research on the development of the human brain that has revolutionized concepts. Particularly, the notions of plasticity, neuronal selection, and the effects of afferent stimuli have entered into thinking about brain development. Here I focus on development from the age of four years to early adulthood, during which a 30 percent reduction in some brain synapses occurs that is out of proportion to changes in neuronal numbers. This corresponds temporally with changes in normal child behavior from the loose‐associative, almost schizoid, thinking and art of the four‐year‐old to the more trained, or disciplined, or acculturated—and restrained—personality of the young adult. I propose that the synaptic changes can best be thought of as a winnowing process likely subject to environmental influences. Acquisition of language and the ability to link linguistic cognition to the plastic development of the brain provide a potentially powerful means of explaining the evolutionally explosive development of human cognition and culture. Schizophrenia, a disease that can be envisioned as representing a derangement of synaptic maturation, may provide an entry into the search for genes controlling the processes mediating the unprecedented development of Homo sapiens over the past 40,000 to 70,000 years. The recently completed mapping of the genome of the chimpanzee provides a new frame of reference that may speed the search.     

FROM PESSIMISM TO HOPE: A NATURAL PROGRESSION

Mutual critique by scientists and religious believers mostly entails the pruning of untenable religious beliefs by scientists and warnings against scientific minimalism on the part of believers. John F. Haught has been prominent in formulating religious apologetics in response to the challenges posed by evolutionary theory. Haught's work also resonates with a parallel criticism of the conventional scientific metaphysics undergirding neo‐Darwinian theory. Contemporary systems ecology seems to indicate that nothing short of a complete reversal of the Enlightenment assumptions about nature is capable of repositioning science to deal adequately with the origin and dynamics of living systems. A process‐based alternative metaphysics substantially mitigates several ostensible conflicts between science and religion.     

A WORLD OF CONTINGENCIES

Abstract Physicalism holds that the laws of physics are inviolable and ubiquitous and thereby account for all of reality. Laws leave no “wiggle room” or “gaps” for action by numinous agents. They cannot be invoked, however, without boundary stipulations that perforce are contingent and which “drive” the laws. Driving contingencies are not limited to instances of “blind chance,” but rather span a continuum of amalgamations with regularities, up to and including nearly determinate propensities. Most examples manifest directionality, and their very definition encompasses intentionality. Contingencies, via their interactions with laws, can reinforce and maintain one another, thereby giving rise to enduring, ordered configurations of constraints. All of ordered nature thus results from ongoing transactions between mutualistic contingencies that constrain possibilities and entropic chance events that degrade order but diversify opportunities. Laws do not of themselves determine reality; interactions among contingencies do. For believers, the robust abundance of indeterminacies provides ample latitude for divine intervention, free will, and prayer. The priority of contingency also affords some insight into the meaning of suffering and evil.     

Evolutionary Pluralism: A New System of Systems Philosophy

When Darwin wrote his ‘On the origin of species…” (1859) he focused on evolution as a property of living organisms in interaction with abiotic and biotic elements in the world. This viewpoint is still dominant amongst biologists. For particle physicists and cosmologists evolution refers to a larger scale, ranging from quarks and atoms to galaxies, stars and planets (i.e. Pagels 1985, Hawking 1988). To close the gap between such different viewpoints, a wide range of perspectives on an interdisciplinary understanding of system development has been published (i.e. Teilhard de Chardin 1966, von Bertalanffy 1968, Varela 1979, Prigogine and Stengers 1984, Laszlo 1996). As an integrative concept, the construction of nature from a hierarchy of system layers forms a central tenet in general system research and the stepwise construction of this layered hierarchy can be regarded as an interdisciplinary evolution theory. Surprisingly, the literature offers no unequivocal rules to recognise a multilayer hierarchy in nature. This presents an obstacle for interdisciplinary approaches to evolution.

Searching a solution to part of the above hierarchy problem, the present paper is dedicated to the analysis of a special kind of layering in natural systems, which is based on transitions between ‘building block’ systems. To identify these building blocks, and the transitions from building block x at level A, to building block y at level B, the focus of this study is further limited to ‘hypercydic dynamics’ and ‘containment’. On the basis of these criteria, a hierarchy is created which shows no possibilities for ‘bypasses’. It connects hadrons to atoms, atoms to cells, and cells to neural networks. Implications of this hierarchy for system studies and evolution are discussed.