替格瑞洛与氯吡格雷对急性STEMI患者急诊PCI术后炎症因子的影响

为比较替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死（STEMI）患者急诊经皮冠状动脉介入术（PCI）术后炎症因子的影响,将176例急性STEMI且行急诊PCI术的患者分为替格瑞洛组（A组）58例、氯吡格雷常规组（B组）58例、氯吡格雷强化组（C组）60例,分别测定术前、术后12小时、术后7天、术后1个月、术后3个月、6个月时炎症因子e反应蛋白（CRP）、白细胞介素-6（IL6）、髓过氧物酶（MPO）、可溶性CD40受体（sCD40L）的含量,比较3组患者各炎症因子在不同时间点有无统计学差异。结果显示c组和A组较B组明显降低（P〈0．05）,有统计学意义,而A组较c组稍降低（P〉0．05）,但两者无统计学意义。由此可见,替格瑞洛的抗炎作用较常规剂量氯吡格雷作用明显增强,和强化剂量氯吡格雷作用相仿。     

Witnessing excellence in action: the ‘other-praising’ emotions of elevation,gratitude, and admiration

People are often profoundly moved by the virtue or skill of others, yet psychology has little to say about the ‘other-praising’ family of emotions. Here we demonstrate that emotions such as elevation, gratitude, and admiration differ from more commonly studied forms of positive affect (joy and amusement) in many ways, and from each other in a few ways. The results of studies using recall, video induction, event-contingent diary, and letter-writing methods to induce other-praising emotions suggest that: elevation (a response to moral excellence) motivates prosocial and affiliative behavior, gratitude motivates improved relationships with benefactors, and admiration motivates self-improvement. Mediation analyses highlight the role of conscious emotion between appraisals and motivations. Discussion focuses on implications for emotion research, interpersonal relationships, and morality.     

What triggers prosocial effort? A positive feedback loop between positive activities,kindness, and well-being

Across two studies, we found evidence supporting a positive feedback loop between positive activities, kindness and well-being. In Study 1, participants were randomly assigned to one of four distinct positive activities (versus a neutral writing activity) before spending three weeks engaging in kind acts. We found that the positive activities served as triggers – that is, they predicted greater prosocial effort, which in turn predicted greater well-being immediately following the intervention and at a two-week follow-up. In Study 2, we explored the specific effects of a gratitude trigger, and extended the intervention period to six weeks. Although, we did not replicate the direct effect of the gratitude trigger on prosocial effort, people who wrote gratitude letters (versus writing about their week) reported relatively greater elevation, which predicted greater prosocial effort during the six weeks. In turn, replicating Study 1, greater effort predicted higher well-being immediately following the study.     

The coordination of shoulder girdle muscles during repetitive arm movements at either slow or fast pace among women with or without neck-shoulder pain

Purpose: The aim of this study was to evaluate the coordination of the shoulder girdle muscles among subjects with or without neck-shoulder pain performing repetitive arm movement at either a slow or fast pace. Methods: Thirty female adults were allocated to one of two groups—healthy controls or cases with neck-shoulder pain. Surface electromyography (sEMG) signals from the clavicular, acromial, middle and lower trapezius portions and the serratus anterior muscles were recorded during a task performed for 20 min at a slow pace and 20 min at a fast pace. The root mean square (RMS), relative rest time (RRT) and normalised mutual information (NMI, an index of functional connectivity between two muscles in a pair) were computed. Results: No significant differences on RMS, RRT and NMI were found between groups. For both groups, the fast movement pace resulted in increased levels of RMS, lower degrees of RRT and higher NMI compared to the slow pace. No interaction between group and movement pace was found. Conclusions: This study highlights the change in sEMG activity of muscles to meet the demands of performing a task at fast movement pace. The fast pace imposed a higher muscle demand evidenced by increased sEMG amplitude, low degree of muscle rest and increased functional connectivity for subjects in both the case and control groups. No indication of impaired sEMG activity was found in individuals with neck-shoulder pain.     

善因营销的捐赠水平与消费者态度:一个有中介的调节效应模型检验

通过两个实验,探讨了善因营销的捐赠水平对消费者态度的影响,尤其是考察了道德提升感的中介作用以及产品-公益事业拟合度的调节作用。研究发现,善因营销的捐赠水平对消费者态度有显著的正向影响,且道德提升感在捐赠水平与消费者态度之间起中介作用。与此同时,产品-公益事业拟合度显著地调节了捐赠水平与道德提升感的关系,且该调节关系通过道德提升感的中介作用来进一步影响消费者态度。     

溶栓后PCI,从不行到可行

再灌注治疗STEMI的方法有直接PCI和溶栓。我国各地医疗条件差别较大,只有12%的STEMI患者能够及时接受直接PCI,超过半数的患者仍行溶栓治疗,故溶栓在我国再灌注策略中占有重要地位。虽然溶栓后即刻PCI即易化PCI被证实不如直接PCI,但溶栓并非STEMI治疗的终点。目前国外循证证据显示溶栓后早期转运PCI优于溶栓失败后再转运行补救PCI,值得我国借鉴学习。     

Viral videos and virtue: Moral elevation inductions shift affect and interpersonal goals in daily life

Laboratory studies suggest that witnessing virtuous acts triggers moral elevation, an emotion characterized by feeling uplifted and increased prosocial motives. However, it remains unknown whether regular inductions can increase elevation and prosocial motives in daily life without being vulnerable to habituation or adaptation effects. Participants (total N = 181) were randomly assigned to elevating vs. neutral or amusing inductions (video or recall tasks) for seven days (Study 1), ten days (Study 2), or 12 days over one month (Study 3). Multilevel growth models showed that relative to comparison conditions, elevation inductions increased daily elevation, positive affect, and prosocial outcomes (compassionate goals and affiliation), and decreased self-protective motives (self-image goals). Adaptation effects occurred for immediate responses when exercises occurred daily, but not when spaced out over time, and not for outcomes measured later each day. Results suggest benefits of brief, regular elevation experiences and have implications for interventions targeting specific emotions.     

替罗非班不同给药途径对DM合并急性STEMI患者PCI术后血小板α-颗粒膜蛋白及心肌灌注水平的影响

为探讨替罗非班不同给药途径对糖尿病（DM）合并急性ST段抬高型心肌梗死（STEMI）患者PCI术后血小板α-颗粒膜蛋白及心肌灌注水平的影响,对149例DM合并急性STEMI患者进行研究,测定并比较经静脉（A组）、冠脉给药途径（B组）和无替罗非班（C组）的患者术前及术中应用替罗非班后血小板α-颗粒膜蛋白GMP140浓度、造影结果、心肌酶及肌钙蛋白I水平峰值及峰值时间、心电图变化。结果显示A、B两组术中血小板α-颗粒膜蛋白浓度较术前明显降低（P〈0．05）,且B组较A组降低更明显（P〈0．05）,而C组未见明显变化（P〉0．05）,A、B两组术后即刻TIMI血流、2h sumSTR、心肌酶及肌钙蛋白Ⅰ峰值及峰值时间的变化均优于C组（P〈0．05）,且B组优于A组（P〈0．05）。因此,替罗非班可以降低血小板α-颗粒膜蛋白浓度和改善心肌灌注水平,与静脉途径给药相比,经冠脉给药更具有优势。     

Experimentally distinguishing elevation from gratitude: Oh,the morality

Elevation has garnered empirical support as the emotional response to witnessing moral beauty. The current studies investigated elevation’s construct validity by experimentally testing whether feelings of elevation are distinct from gratitude, another moral and ‘other-praising’ emotion. Study 1 demonstrated that feelings of elevation are distinct from gratitude, serenity (i.e. a secondary comparison condition), and boredom (i.e. a control condition). Study 2 added a behavioral outcome measure in the form of monetary donations to a moral charity. The third study expanded on Study 2 by randomly assigning participants to an elevation or gratitude mood induction and then randomly assigning them to have the opportunity to donate to either a moral or an amoral charity. Together, these studies support Haidt’s conceptualization of elevation, clarify Algoe and Haidt’s qualitative assessment of the emotional differences between elevation and gratitude, and reveal that elevation results in different behavioral responses than gratitude.