右美托咪定与丙泊酚在胸科手术中的麻醉效果对比

观察右美托咪定（Dex）联合瑞芬太尼在胸科手术麻醉过程中的应用。选取择期全麻下行开胸手术患者78倒,按随机分为两组（每组39例）：试验组采用Dex、瑞芬太尼和七氟烷静吸复合麻醉（I组）,对照组采用瑞芬太尼、丙泊酚和七氟烷静吸复合麻醉（Ⅱ组）。试验组患者苏醒期躁动明显少于对照组（P〈0．05）,两组苏醒时间差异无统计学意义（P〉0．05）。因此,Dex联合瑞芬太尼在胸科手术麻醉中能够安全有效地抑制双腔气管插管反应,保持血流动力学的稳定,同时明显减少患者在苏醒期躁动。     

On no man’s land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents

To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine in healthy male participants (N = 140). The anesthetics were administered in experimental setting using target-controlled infusion or vapouriser for one hour. Interviews conducted after anesthetic administration revealed that 46.9% (n = 46) of arousable participants (n = 98) reported experiences, most frequently dreaming or memory incorporation of the setting. Participants receiving dexmedetomidine reported experiences most often while S-ketamine induced the most multimodal experiences. Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.