Impulsive responses to positive mood and reward are related to mania risk

Bipolar disorder is characterised by impulsivity, and recent research suggests it is important to consider more specific forms of impulsivity. In two student samples, we examined associations of self-reported impulsivity with mania risk (Hypomanic Personality Scale, HPS). We hypothesised that mania risk would relate to impulsivity in the context of opportunities for rewarding activities (Delaying Gratification Inventory, DGI), reward pursuit (Fun-Seeking subscale of the Behavioural Activation Scale, BAS), and when experiencing positive affect (Positive Urgency Measure, PUM). In Study 1 (N=823), the HPS was uniquely related to Fun-Seeking and PUM scores. Study 2 (N=482) replicated the correlation of HPS scores with PUM while documenting positive associations between PUM and trait-like responses to positive affect. Findings across both studies stress the importance of considering the role of positive emotion in driving the impulsivity among persons at risk for mania. These findings have implications for refining our understanding of the aetiology of bipolar disorder and for treatment development.     

The neural control of mood: the possible role of the adrenergic system in the medulla

Mood in humans is a complex phenomenon that integrates emotion (e.g. happiness and sadness), cognition, perception, ideation, and action in a coherent manner. In bipolar disorder extremes of mood (up or down) occur outside the normal range, in which all the above functions are coherently affected. Mood is controlled by a series of separate but interactive brain circuits that involve much of the brain, but particularly the limbic system. The question addressed in this paper is whether the coordination of all these separate systems into one coherent functional mood is mediated by non-linear dynamics acting between these systems as equal participants; or whether it is affected by a single master regulator controlling the others. The possible roles, as master regulators, of non-linear dynamically linked populations of neurons, and of the C1–C3 adrenergic nuclei in the medulla is discussed.     

Mood stability versus mood instability in bipolar disorder: a possible role for emotional mental imagery

A cognitive model of bipolar disorder suggests that mental imagery acts as an emotional amplifier of mood and may be heightened in bipolar disorder. First, we tested whether patients with bipolar disorder would score higher on mental imagery measures than a matched healthy control group. Second, we examined differences in imagery between patients divided into groups according to their level of mood stability. Mood ratings over approximately 6-months, made using a mobile phone messaging system, were used to divide patients into stable or unstable groups. Clinician decisions of mood stability were corroborated with statistical analysis. Results showed (I) compared to healthy controls, patients with bipolar disorder had significantly higher scores for general mental imagery use, more vivid imagery of future events, higher levels of intrusive prospective imagery, and more extreme imagery-based interpretation bias; (II) compared to patients with stable mood, patients with unstable mood had higher levels of intrusive prospective imagery, and this correlated highly with their current levels of anxiety and depression. The findings were consistent with predictions. Further investigation of imagery in bipolar disorder appears warranted as it may highlight processes that contribute to mood instability with relevance for cognitive behaviour therapy.     

Extraversion and psychopathology: A multilevel hierarchical review

We examine relations between extraversion and psychopathology, using a four-level hierarchical structure in which the general domain is divided into two aspects (Communal Extraversion, Agentic Extraversion), four consensual facets (Sociability, Liveliness, Venturesomeness, Dominance), and six NEO facets (Gregariousness, Warmth, Positive Emotions, Activity, Excitement-Seeking, Assertiveness). Our review indicates that extraversion’s negative correlations with depression primarily reflect the aspect of Communal Extraversion, the consensual facet of Liveliness, and NEO Positive Emotions. Its negative associations with social dysfunction largely are due to the aspect of Communal Extraversion, the consensual facet of Sociability, and NEO Warmth, Gregariousness, and Positive Emotions. Finally, externalizing and mania are positively related to the aspect of Agentic Extraversion, the consensual facets of Venturesomeness and Dominance, and NEO Excitement-Seeking.     

"I won't do what you tell me!": elevated mood and the assessment of advice-taking in euthymic bipolar I disorder

We hypothesized that when individuals with bipolar disorder are engaged in goal-directed behaviour and experience elevated mood, their decision-making becomes less constrained by advice from other people. This process may allow their goal-directed behaviour to persist, contributing to manic symptoms. Three groups of 32 participants: euthymic-bipolar-I, remitted-unipolar and never-depressed healthy controls were allocated to either a high or low mood induction. Advice-taking was assessed before and after the induction by a computerized task incorporating facial images. The bipolar group significantly opposed the advice given in the task after the high mood induction. The effect was specific to bipolar disorder and remained when controlling for possible confounds. Future work could investigate the effects of this process on manic symptoms, its origins, and the wider theoretical and clinical implications.     

Contact high: Mania proneness and positive perception of emotional touches

How do extreme degrees of positive emotion—such as those characteristic of mania—influence emotion perception? The present study investigated how mania proneness, assessed using the Hypomanic Personality Scale, influences the perception of emotion via touch. Using a validated dyadic interaction paradigm for communicating emotion through touch (Hertenstein, Keltner, App, Bulleit, & Jaskolka, 2006), participants (N=53) received eight different touches to their forearm from a stranger and then identified the emotion via forced-choice methodology. Mania proneness predicted increased overall accuracy in touch perception, particularly for positive emotion touches, as well as the over-attribution of positive and under-attribution of negative emotions across all touches. These findings highlight the effects of positive emotion extremes on the perception of emotion in social interactions.