Short and long-term motor skill learning in an accelerated rotarod training paradigm

Rodent models of motor skill learning include skilled forelimb reaching and acrobatic locomotor paradigms. This study characterizes motor skill learning in the accelerated rotarod task. Thirty Long-Evans rats (300-400 g) were trained on an accelerated rotarod (1cm/s(2)) over eight consecutive sessions (=days, 20 trials each). Improvement in rotarod velocities mastered before falling off the rod was observed within and between sessions (plateau after five sessions). Intrasession improvement was incompletely retained at the beginning of the next day's session. Over several training sessions, intrasession improvement diminished, suggesting a ceiling effect. After 1 week of pause, the rotarod skill was retained. Locomotor exercise in a running wheel for 30 min before the first rotarod session did not affect intrasession improvement. Running-wheel exposure for 6 days did not diminish the rate of rotarod skill learning (steepness of the learning curve) but improved overall performance (upward shift of curve). Video analysis of gait on the rotarod showed that rats developed a motor strategy by modifying their gait patterns during training. The data demonstrate that rotarod improvement is not the result of enhanced general locomotor ability or fitness, which are trained in the running wheel, but requires a change in the motor strategy to master the task. Accelerated rotarod training can be regarded a valid paradigm for motor skill learning over short (intrasession, minutes) and long time frames (intersession, days).     

The planning and execution of sequential eye movements: saccades do not show the one target advantage

The present experiment examined the one-target advantage (OTA) with regard to saccadic eye movements. The OTA, previously found with manual pointing responses, refers to the finding that movements are executed faster when the limb is allowed to stop on the target compared to the situation where it has to proceed and hit a second target. Using an adapted limb movement OTA task, saccades of 5 degrees and 15 degrees were made to (a) a single target (one-target), (b) one target and immediately to another target without a change in direction (two-target-extension), and (c) one target and immediately back to the start location (two-target-reversal). Unlike manual movements, the movement times for the initial saccade in the two-target-extension condition were not prolonged compared to either of the other two conditions. Moreover, this pattern of results was found for both the shorter and longer amplitude saccades. The results indicate that the OTA does not occur in the oculomotor system and therefore is not a general motor control phenomenon.     

A Business Model for Managing System Change Through Strategic Financing and Performance Indicators: A Case Study

This article describes how a system of care operated by a county government agency used a fiscal crisis as the opportunity to reform its children's system. A cross-system response to the crisis is outlined that includes a system of care framework coupled with a business model, inter-departmental collaboration and leadership, the use of strategic reinvestment strategies, and a quality improvement system that focuses on key indicators. Implementation of the system change is described with a specific focus on cross-system entry points, financing strategies that re-allocate funds from deep-end programs to community-based services, and management oversight through the use of performance indicators to monitor and support effectiveness. This article examines the results of the system change, including the diversion of youth from system penetration, the reduction in residential treatment bed days, the re-allocation of these savings to community-based services, and the outcomes of children who were diverted from residential care and served in the community. The article offers a number of recommendations for other communities contemplating system change.     

Minimally Creative Thought

Creativity has received, and continues to receive, comparatively little analysis in philosophy and the brain and behavioural sciences. This is in spite of the importance of creative thought and action, and the many and varied resources of theories of mind. Here an alternative approach to analyzing creativity is suggested: start from the bottom up with minimally creative thought. Minimally creative thought depends non‐accidentally upon agency, is novel relative to the acting agent, and could not have been tokened before the time it is in fact tokened, relative to the agent in question. Thoughts that meet these three conditions—agency, psychological novelty, and modal—are what may be called cognitive breakthroughs. Even if such breakthroughs are not necessary to or definitive of richer creativity, they are indeed central to much of creativity. The minimal analysis provides a more workable explanandum for theories of creativity of varied motivation and method.     

Understanding the relationships between age,gender, and life satisfaction: the mediating role of stress and religiosity

Although hundreds of investigations have examined the relationship between age and life satisfaction, a recent review of these studies reveals that relatively little is known about the nature of this relationship, especially between genders and across cultures, and the mechanisms that link age to life satisfaction. Using a large-scale study in Malaysia, the present research explores the mediating effects of stress and religiosity that might be responsible for the empirical findings reported in previous studies. Contrary to previous findings based on US studies, this study finds that women are more satisfied with their lives than men in the early and later stages of life. Chronic stress and religiosity were found to partially mediate the relationship between age and life satisfaction, suggesting that these may be mechanisms that explain the findings of previous studies.     

新生市民主动发展倾向对城市生活适应性的影响:社会支持的中介效应

为探究主动发展倾向和社会支持对新生市民城市生活适应性的作用机制,本研究构建了结构方程模型.采用两个自编量表和一个现成量表,运用两阶段抽样调查法,在作为统筹城乡发展试验区的重庆市范围内,对已经取得城镇户口的新生市民进行问卷调查,获得有效样本322人.对采集的数据运用统计分析软件SPSS17.0和AMOS18.0进行数据分析和模型检验.结果表明,城市化新生市民的主动发展倾向和社会支持均对新生市民的城市生活适应具有显著影响,其中,社会支持在主动发展倾向对城市生活适应影响中具有部分中介作用.     

Psychobiography in psychology: Past,present, and future

The present article reviews the history and emerging trends in the field of psychobiography. Five historical periods are highlighted: hagiography and pre-19th century study of lives; Freud and applied psychoanalysis; psychodynamic extensions and personology; modern multi-theoretical models; and psychobiography as interdisciplinary science. The author advocates for a science of psychobiography manifested in expanded and empirically validated theoretical models anchoring research. Further, attention is drawn to the need for more rigorous historiographic research methods weighting first-person sources and incorporating mixed methods designs. Increased attention to ethical and legal issues in the conduct and reporting of psychobiographical studies is also highlighted. Finally, emerging trends in psychobiography related to research production, academic training, and organisational initiatives are presented.     

Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

Experience-dependent plasticity is thought to involve selective change in pre-existing brain circuits, involving synaptic plasticity. One model for looking at experience-dependent plasticity is environmental enrichment (EE), where animals are exposed to a complex novel environment. Previous studies using electron microscopy showed that EE resulted in synaptic plasticity in the visual cortex and hippocampus. However, the areas in the brain that have been examined following EE have been limited. The present study quantified potential synaptic plasticity throughout the brains of C57BL/6 mice using an enzyme-linked immunosorbent assay (ELISA) for two synaptic proteins, synaptophysin and PSD-95. EE resulted in increased synaptophysin and PSD-95 levels through major brain regions, including anterior and posterior areas of the forebrain, hippocampus, thalamus, and hypothalamus. However, no changes in synaptophysin were detected in the cerebellum. These results demonstrate that EE results in an increase in levels of both pre- and post-synaptic proteins in multiple regions of the brain, and it is possible that such changes represent the underlying synaptic plasticity occurring in EE.     

今本《周易》卦序排列数学规律新探

今本《周易》六十四卦卦序是依据什么道理排列出来的,迄今仍然没有一个完美的解答。本文尝试把卦序问题作为一个数学问题去考虑,探讨卦序的制作者所依据的数学思想与技巧。《六十四卦错综图》是我们研究序卦最重要的参考图,并指出十对三明三阳卦在序卦排列中起着骨架作用．无论是十对三明三阳卦,还是围绕这十对卦左右的其它卦,其排列在序数配置、卦区划分和爻画布排等诸多方面都蕴含着丰富的数学内容,充分反映了序卦的制作者运用数学技巧的娴熟技艺和精妙构想。