Influence of perinatal complications on the development of a sample of 36-month-old premature infants

ObjectiveThe lack of clear results in previous studies for this context makes us consider an exploratory study. The objective of this research is to examine the influence of certain perinatal factors on the development of premature infants over their first 36 months of life.MethodThe sample consisted of 59 preterm infants born between 25 and 34 weeks of gestational age in an NICU of a third-level hospital. At 36 months of age, the Bayley-III Infant Development Scale (Spanish adaptation) and a clinical history were collected.ResultsThe average scores on the Bayley-III Infant Development Scale were generally within the normal range, but significantly lower than normal for Fine Motor Function, Gross Motor Function, and Expressive Language. These differences remained when considering the degree of prematurity, gender, and perinatal complications. Infants who received mechanical ventilation, oxygen therapy or corticosteroid treatment due to bronchopulmonary dysplasia showed the greatest discrepancies from normal levels.ConclusionOur results support prior studies that show that a combination of perinatal risk factors constitutes the largest determinant for developmental issues at 36 months of age. This information establishes the need for a priority follow-up in this population beyond 24 months of corrected age.     

A call to restructure the drug development process: Government over-regulation and non-innovative late stage (Phase III) clinical trials are major obstacles to advances in health care

The history of drug/vaccine development has included major advances guided primarily by risk/benefit analyses concerning the innovative agent, not by evidence-based clinical trials (Phase I–IV). Because the approval for new drugs is hindered under the present process, the system requires restructuring. The Phase I/II study period should be more flexible, using the “environment of knowledge” about the new agent, plus risk/benefit assessments. Phase III, as presently constructed, does not add new adverse events data, it provides a narrower profile of drug efficacy than properly done Phase II studies, and placebo-controlled trials continue to raise unresolved ethical and social issues. Phase III studies should be abandoned for most drugs, and substituted with properly powered Phase II doseranging studies plus careful post-marketing surveillance. Phase III should be a penalty for poor drug development, not a regulatory requirement. To accomplish efficient drug development, greater cooperation between pharmaceutical companies and governments in developing clinical trials is needed rather than over-regulation. These changes will synchronize the drug development and regulatory process with the current rapid drug discovery process, reduce drug development time and cost, and improve patient care. The author is Adjunct Professor of Medicine, Weill Medical College of Cornell University, New York, New York, USA.     

The key role of nanoscale surface facets on the mechanical strength and failure of wurtzite and periodically twinned zinc-blende nanowires

Using molecular dynamics, we study the role of the surface facets of III–V nanowires on their failure during tensile deformation. We find that wurtzite (WZ) nanowires can withstand higher levels of stress and strain at failure compared to zinc-blende (ZB) nanowires. We observe that it is easier to nucleate a crack on a ZB nanowire due to the stress singularities that occur at the intersection of two opposing {111} facets. In WZ nanowires, we observe that cracks always nucleate at the intersection between two adjacent {112} surface facets. We explain these phenomena using fracture mechanics techniques based on energetics of crack formation.     

Bayley‐III: Cultural differences and language scale validity in a Danish sample

The purpose of this study was to investigate cultural differences between Danish and American children at 2 and 3 years as measured with the developmental test Bayley‐III, and to investigate the Bayley‐III Language Scale validity. The Danish children (N = 43) were tested with the Bayley‐III and their parents completed an additional language questionnaire (the MacArthur‐Bates CDI). Results showed that scores from the Danish children did not differ significantly from the American norms on the Cognitive or Motor Scale, but the Danish sample scored significantly higher on the Language Scale. A comparison of the Bayley‐III Language subtests with the CDI showed that the two measures correlated significantly, but the percentile score from the CDI was significantly higher than the percentile score from the Bayley‐III Language subtests. This could be because the two instruments measure slightly different areas of language development, or because the Bayley‐III overestimates language development in Danish children. However, due to the limitations of the current study, further research is needed to clarify this issue.     

TELEOLOGY PAST AND PRESENT

Abstract. Current teleology in Western biology, philosophy, and theology draws on resources from four main Western philosophers. (1) Plato's Timaeus shows how to interpret the universe as the handiwork of a purposive Creator who subordinates secondary, necessary, causes to primary, intelligent, causes. (2) Aristotle's Physics sets forth purpose as implicit in the nature of things. Purposes of different sorts inhere in different types of being, and everything has a natural function. Living things grow to actualize the potentials of the goal whose principle they bear within themselves. (3) Kant's Critique of Judgment denies that purpose is anything that human beings can know, strictly speaking. Nevertheless, purpose is a concept we must use to make sense of biological systems. (4) Hegel's Philosophy of Nature articulates organic systems as dialectically including and transcending mechanical and chemical systems. Teleological themes persist, in different ways, in contemporary discussions; I consider two lines of criticism of traditional teleology—by Richard Dawkins and Stephen Jay Gould—and one line that continues traditional teleology in an updated way—by Holmes Rolston, III.     

Effects of felt adequacy and opportunity to reciprocate on help seeking

This experiment was prompted by the belief that felt inadequacy and lack of opportunity to reciprocate act as deterrents to help seeking when help is needed. The experiment was conducted on 56 freshmen by modifying Greenberg and Shapiro's physical disability paradigm. Subjects were told that they could not meet the quota on a manual task but had done well (poorly) for persons similarly handicapped (by arm in sling). Later they learned that the electricity would be shut off in 2 hr (15 min), making it possible (impossible) to help the visually handicapped fellow worker later on a visual task. The hypothesis that felt inadequacy inhibits help seeking was fully supported, while the corresponding hypothesis regarding lack of opportunity to reciprocate received only partial support. There were no sex differences. The relevance of these data for embarrassment theory is discussed.     

Parameter estimation for the thurstone case III model

A Monte Carlo study was conducted to investigate the ability of three estimation criteria to recover the parameters of Case V and Case III models from comparative judgment data. Significant differences in recovery are shown to exist.This research was supported by grant SOC76-20517 from the National Science Foundation. The authors acknowledge with appreciation comments received on an earlier draft by Harold Lindman, Joseph Zinnes, and anonymous reviewers.     

A Comprehensive Decision Approach for Rubber Tree Planting Management in Africa

The main objective of this study is to settle a rigorous field of decision analysis for rubber tree clones selection. Nowadays, there does not exist any process based upon a rigorous method to select the best clone to be plant in order to get the highest return on investment. The only known selection method is to use the experience of different protagonists acting in the plantation. So, we need a tool that takes into account very important criteria in order to achieve the main objective. This goal is achieved by using multicriterion analysis methods to the clone selection. The ranking procedure uses Elimination and Choice Expressing the Reality (ELECTRE III). For each criterion, indifference and preference thresholds are determined after establishing the relative importance of each criterion including rubber tapping, cumulative production during 15 years, cumulative production between 15 and 25 years, wind resistance, disease resistance, physiological resistance, grafting and quality of the rubber. Copyright © 2011 John Wiley & Sons, Ltd.