人乳头瘤病毒与宫颈癌的关系及启示

分子流行病学明确表明某些特定型别的人乳头瘤病毒（HPV）感染是浸润性宫颈癌和宫颈上皮内病变的主要致病原因。在HPV与宫颈癌的关系研究中无时无刻不渗透着马克思主义哲学原理,从哲学的角度去思考将使我们更科学、更透彻地理解两者的关系。     

Social-cognitive predictors of intention to vaccinate against the human papillomavirus in college-age women

This study examined social-cognitive predictors of college-age women's intentions to obtain the human papillomavirus (HPV) vaccine using the Health Belief Model (HBM) and Theory of Planned Behavior (TBP) as theoretical guides. Questionnaire data were collected from 143 women at a Midwestern university. Among the HBM variables, perceived susceptibility to HPV, perceived benefits of the vaccine, and self-efficacy to obtain the vaccine were significant predictors. Among the TPB variables, positive attitudes toward the vaccine and beliefs that important others would support vaccination predicted intentions. A model with all HBM and TPB variables explained nearly 60% of the variance in intentions. Comparison of the theories suggests that the TPB is a better predictor of intentions than the HBM. Results suggest that targeting personal beliefs about the vaccine, and increasing acceptance for the vaccine among social network members, may increase vaccination intentions among college-age women.     

宫颈癌病因及预防

从哲学角度讨论宫颈癌的病因,思考临床工作中如何预防宫颈癌。宫颈癌的发生是内因外因综合作用的结果。实验与临床研究发现人类乳头瘤病毒（HPV）家族中的高危型HPV的持续感染是宫颈癌及其癌前病变发生的主要外因。本文将讨论HPV分型检测作为宫颈癌筛查系统的一个重要元素在预防宫颈癌发生中所处的地位。     

A qualitative analysis of the vaccine intention–behaviour relationship: parents’ descriptions of their intentions,decision-making behaviour and planning processes towards HPV vaccination

Objective: The objective of this study is to identify factors influencing the vaccine intention–behaviour relationship. Design: A total of 445 parents who received a brief intervention to promote HPV vaccination were categorized based on their intentions post-intervention (yes/unsure/eventually/never) and subsequent adolescents’ vaccine status (yes/no). Fifty-one of these parents participated in qualitative interviews. Main Outcome Measures: Parents described their intentions, decision-making and planning processes towards vaccination. Framework analysis was used to analyse the data. Results: Parents in the ‘Yes/Yes’ category were knowledgeable about HPV/vaccine, described strong, stable intentions, considered themselves the primary decision-makers about vaccination and said they vaccinated immediately. ‘Yes/No’ parents described strong intentions and thought their adolescent was vaccinated OR described hesitant intentions, seeking advice/agreement from others and noting barriers to vaccination without solutions. ‘Unsure/Yes’ parents described their intentions as strengthening with information from credible sources and identified strategies for overcoming barriers. ‘Unsure/No’ and ‘Eventually/No’ parents had misinformation/negative beliefs regarding vaccination, described being ambivalent or non-supportive of vaccination and cited barriers to vaccination. ‘Never/No’ parents held negative beliefs about vaccination, described strong, stable intentions to NOT vaccinate, deferring the decision to others, and reported no planning towards vaccination. Conclusions: Intention characteristics and planning processes could moderate the vaccine intention–behaviour relationship, potentially serving as targets for future vaccine strategies.     

宫颈癌病毒病因学说的确立及其发展

德国病毒学家Harald zur Hausen博士创立的宫颈癌人乳头瘤病毒（HPV）病因学说荣获2008年度诺贝尔生理学/医学奖。笔者从辩证唯物主义认识论角度,回顾了该学说的确立及其发展。宫颈癌将有望成为人类通过疫苗接种、筛查和早诊早治等综合措施来预防乃至消除的第一个恶性肿瘤。     

Respiratory sinus arrhythmia in response to fear-relevant and fear-irrelevant stimuli

Heart period variability and heart rate were studied in 15 women and 15 men while they were viewing negatively (snakes/spiders), neutrally (scenic views), and positively (cats and kittens/puppies and dogs) valenced films. Time-frequency analyses of the heart period variability power spectrum in the high frequency region (0.12-0.4 Hz), reflecting respiratory sinus arrhythmia (RSA), were carried out during 5 minutes in each condition. The main finding showed that RSA-magnitude (high frequency power) was inversely related to emotional valence: lowest magnitudes were found in response to positive films, and highest magnitude to negative films. The findings were interpreted as reflecting motor or behavioral inhibition, and increased attention to negatively valenced, stimuli.     

Factors associated with school nurses’ HPV vaccine attitudes for school-aged youth

School nurses are at the intersection of the healthcare and school communities, thus, they can be considered opinion leaders in providing health advice – including information about the human papillomavirus (HPV) vaccine – to parents and students. This study examined school nurses’ attitudes toward the HPV vaccine based on age, years as a school nurse, geographic location, urban vs. rural work setting, HPV and vaccine knowledge, perception of role as opinion leaders, and school district support in providing health education. Participants (n = 413) were systematically sampled from the National Association of School Nurses’ membership and completed a web-based survey. Multiple regression was used to predict positive HPV vaccine attitudes. The model was statistically significant accounting for 50.8% of the variance (F [9, 400] = 45.96, p < .001). Positive attitudes regarding the HPV vaccine were predicted by higher HPV and vaccine knowledge (β = .096, p < .001) and stronger perceptions of role as opinion leaders for the vaccine (β = .665, p < .001). No other variables were found to be statistically significant. These results suggest knowledge is essential in predicting positive attitudes, but not the strongest predictor as perceptions of role as opinion leaders was more crucial in terms of predicting school nurses’ positive attitudes towards HPV vaccine. Despite school nurses being seen as champions for adolescent vaccines, they need additional professional development to increase their HPV vaccine knowledge and attitudes to encourage parents and adolescents to consider the uptake of HPV vaccination. To engage school nurses’ in promoting HPV vaccine uptake, interventions need to focus on increasing school nurses’ perception of their role as opinion leaders for HPV vaccine and knowledge to increase positive attitudes towards HPV vaccination for youth.     

Do individual differences in intolerance of uncertainty affect health monitoring?

Researchers have postulated that individual differences in intolerance of uncertainty (IU) may affect people's health behaviours. Study 1 (N?=?147 university students) supports this proposition showing that higher IU is associated with higher monitoring (seeking threat-relevant information). Study 2 (N?=?117 university students) experimentally manipulated IU to ensure that the association is not due to other related constructs such as anxiety or worry. Results show that inducing high IU led to increased monitoring as reflected by higher scores on an index of monitoring measures. Wanting information about the health threat in order to reduce their uncertainty was an independent predictor of monitoring and did not mediate the relationship between IU and monitoring. Findings suggest that high IU induces people to increase their monitoring; an adaptive strategy when the health threat can be reduced through this behaviour.