Massage therapy improves the development of HIV-exposed infants living in a low socio-economic,peri-urban community of South Africa

The aim of this study was to assess the effect of massage therapy on the growth and development of infants of HIV-infected mothers in a low socio-economic community in Cape Town. It was a prospective, randomised, controlled intervention trial that included massage therapy and control groups of HIV-infected mothers and their normal birth weight infants who were enrolled in the prevention of mother-to-child transmission (PMTCT) programme. Participants were recruited at the 6-week clinic visit and followed up every 2 weeks until their infants were 9 months of age. Mother–infant pairs in the massage therapy and control groups included 73 and 88 at 6 weeks and 55 and 58 at 9 months, respectively. Mothers in the intervention group were trained to massage their infants for 15 min daily. The socioeconomic status, immunity, relationship with the partner and mental pain of mothers; the infants’ dietary intake, anthropometry and development (Griffiths Mental Development Scales); and haematological and iron status of mothers and infants were assessed at baseline and follow-up. Nine infants (5.3%) were HIV-infected on the HIV DNA PCR test at 6 weeks. Despite significantly higher levels of maternal mental pain, infants in the massage therapy compared to control group scored higher in all five of the Griffiths Scales of Mental Development and significantly higher in the mean quotient (p = 0.002) and mean percentile (p = 0.004) for the hearing and speech scale at 9 months. Based on the mean difference in scores, the massage therapy group showed greater improvement for all five scales compared to the control group. The mean difference in scores was significantly greater for the hearing and speech quotient (21.9 vs. 11.2) (p < 0.03) and the general quotient percentile (19.3 vs. 7.7) (p = 0.03) in the massage therapy compared to the control group. These scales remained significant when adjusting for the relationship with the partner and maternal mental pain. Both groups had lower scores in the performance scale at 9 months although this was significantly worse in the control compared to the massage therapy group when adjusting for maternal CD4 count, anaemia, relationship with the partner and mental pain. There were no significant differences in the anthropometric measurements between the two groups. In conclusion, based on the Griffiths Scales, massage therapy improved the overall development and had a significant effect on the hearing and speech and general quotient of HIV-exposed infants in this study.     

Comparison of Griffiths-II and Bayley-II tests for the developmental assessment of high-risk infants

IntroductionTwo important risk factors for abnormal neurodevelopment are preterm birth and neonatal hypoxic ischemic encephalopathy. The new revisions of Griffiths Mental Development Scale (Griffiths-II, [1996]) and the Bayley Scales of Infant Development (BSID-II, [1993]) are two of the most frequently used developmental diagnostics tests. The Griffiths-II is divided into five subscales and a global development quotient (QD), and the BSID-II is divided into two scales, the Mental scale (MDI) and the Psychomotor scale (PDI).The main objective of this research was to establish the extent to which developmental diagnoses obtained using the new revisions of these two tests are comparable for a given child.Material and methodsRetrospective study of 18-months-old high-risk children examined with both tests in the follow-up Unit of the Clinic of Neonatology of our tertiary care university Hospital between 2011 and 2012. To determine the concurrent validity of the two tests paired t-tests and Pearson product-moment correlation coefficients were computed. Using the BSID-II as a gold standard, the performance of the Griffiths-II was analyzed with receiver operating curves.Results61 patients (80.3% preterm, 14.7% neonatal asphyxia) were examined. For the BSID-II the MDI mean was 96.21 (range 67–133) and the PDI mean was 87.72 (range 49–114). For the Griffiths-II, the QD mean was 96.95 (range 60–124), the locomotors subscale mean was 92.57 (range 49–119). The score of the Griffiths locomotors subscale was significantly higher than the PDI (p < 0.001). Between the Griffiths-II QD and the BSID-II MDI no significant difference was found, and the area under the curve was 0.93, showing good validity. All correlations were high and significant with a Pearson product-moment correlation coefficient >0.8.ConclusionsThe meaning of the results for a given child was the same for the two tests. Two scores were interchangeable, the Griffiths-II QD and the BSID-II MDI.     

Comparison of social time-out and activity time-out procedures in suppressing ethanol self-administration in alcoholics

The experiments compared the potencies of three different contingent time-out procedures for suppressing drinking in alcoholics, and also compared two different experimental methodologies for conducting such studies. In a residential research ward setting fourteen volunteer chronic alcoholics were given daily access to 17 alcoholic drinks provided that a minimum of 40 min elapsed between receiving successive drinks. Each drink contained 1 oz 95-proof ethanol in orange juice. During the baseline condition subjects were free to drink with no behavioral restrictions. However during the time-out conditions, specific behavioral restrictions were imposed on the subjects for the 40-min period following receipt of each drink. The results showed that Social time-out suppressed drinking to 71 per cent of baseline conditions, while Activity time-out and the combined Social and Activity time-out suppressed intake to 36 and 24 per cent, respectively. The study also demonstrated that similar experimental results were obtained when subjects were continuously exposed to the experimental conditions for a number of consecutive days. or intermittently exposed to different conditions in a mixed order over successive days.     

Evolution and Two Popular Proposals for the Definition of Function

Summary  In the biological realm, a complete explanation of a trait seems to include an explanation in terms of function. It is natural to ask of some trait, “What is its function?” or “What purpose in the organism does the particular trait serve?” or “What is the goal of its activity?” There are several views concerning the appropriate definition of function for biological matters. Two popular views of function with respect to living things are Cummins’ organizational account and the Griffiths/Godfrey-Smith modern history account. Whereas Cummins argues that a trait functions so as to contribute to the general organization of some organism’s present structure, Griffiths, and Godfrey-Smith argue that a trait functions because of its fitness with respect to the organism’s recent evolutionary history. In this paper, I show how these accounts can be made compatible and compliment one another. Given that structure, organization, operational flexibility, function, and evolutionary history are all factors to be considered in an organism’s makeup, we should expect that the traits of an organism function the way they do because such traits presently contribute to the overall organization of the organism (Cummins) as well as were selected for in the organism’s species’ recent ancestry (Griffiths/Godfrey-Smith).