Individual differences in flow proneness are linked to a dopamine D2 receptor gene variant

Flow is a special mental state characterized by deep concentration that occurs during the performance of optimally challenging tasks. In prior studies, proneness to experience flow has been found to be moderately heritable. In the present study, we investigated whether individual differences in flow proneness are related to a polymorphism of the dopamine D2 receptor coding gene (DRD2 C957T rs6277). This polymorphism affects striatal D2 receptor availability, a factor that has been shown to be related to flow proneness. To our knowledge, this is the first study to investigate the association between this trait and a specific gene variant. In a sample of 236 healthy Hungarian adults, we found that CC homozygotes report higher flow proneness than do T allele carriers, but only during mandatory activities (i.e., studying and working), not during leisure time. We discuss implications of this result, e.g., the potential mediators of the relationship.     

Cognitive computing models for estimation of reference evapotranspiration: A review

Irrigation practices can be advanced by the aid of cognitive computing models. Repeated droughts, population expansion and the impact of global warming collectively impose rigorous restrictions over irrigation practices. Reference evapotranspiration (ET₀) is a vital factor to predict the crop water requirements based on climate data. There are many techniques available for the prediction of ET₀. An efficient ET₀ prediction model plays an important role in irrigation system to increase water productivity. In the present study, a review has been carried out over cognitive computing models used for the estimation of ET₀. Review exhibits that artificial neural network (ANN) approach outperforms support vector machine (SVM) and genetic programming (GP). Second order neural network (SONN) is the most promising approach among ANN models.     

L’ADN,la reine des preuves imparfaites

Due to the progress of science and the stakes of inquiry and sentence, the DNA analysis is subject of a substantial development within the area of criminal procedure. However, the DNA is by no means a perfect evidence and it faces scientific, ethic and legal limits which result in reconsidering the balance between the stakes of punishment and the protection of Fundamental Freedoms.     

Fabry disease in genetic counseling practice: recommendations of the National Society of Genetic Counselors

The objective of this document is to provide health care professionals with recommendations for genetic counseling and testing of individuals with a suspected or confirmed diagnosis of Fabry disease, with a family history of Fabry disease, and those identified as female carriers of Fabry disease. These recommendations are the opinions of a multicenter working group of genetic counselors, medical geneticists, and other health professionals with expertise in Fabry disease counseling, as well as an individual with Fabry disease who is a founder of a Fabry disease patient advocacy group in the United States. The recommendations are U.S. Preventive Task Force Class III, and they are based on clinical experience, a review of pertinent English-language articles, and reports of expert committees. This document reviews the genetics of Fabry disease, the indications for genetic testing and interpretation of results, psychosocial considerations, and references for professional and patient resources. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. The professional judgment of a healthcare provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations.     

The Process of Family Reconstruction after DNA Testing for Huntington Disease

The needs of families to reconstruct their relationships in response to the DNA testing for Huntington disease of one or more of their asymptomatic members are presented. Data were collected from family interviews with 18 families, and from their responses on a post interview questionnaire. Findings are that families need to (a) address unfinished business associated with the decision for testing; (b) bring family members, peripheral in the decision for testing, into the loop; (c) reorganize patterns of communication and roles altered by the testing and heal ruptures in family membership; and (d) revise family stories about illness to provide a meaning for HD and explain the test results in a way that leaves them with a sense of mastery. Findings suggest that families should be more involved in the initial decision for testing of a member and that protocols should be established to provide help for their ongoing adjustment.     

Genetic Counseling for Fragile X Syndrome: Updated Recommendations of the National Society of Genetic Counselors

These recommendations describe the minimum standard criteria for genetic counseling and testing of individuals and families with fragile X syndrome, as well as carriers and potential carriers of a fragile X mutation. The original guidelines (published in 2000) have been revised, replacing a stratified pre- and full mutation model of fragile X syndrome with one based on a continuum of gene effects across the full spectrum of FMR1 CGG trinucleotide repeat expansion. This document reviews the molecular genetics of fragile X syndrome, clinical phenotype (including the spectrum of premature ovarian failure and fragile X-associated tremor-ataxia syndrome), indications for genetic testing and interpretation of results, risks of transmission, family planning options, psychosocial issues, and references for professional and patient resources. These recommendations are the opinions of a multicenter working group of genetic counselors with expertise in fragile X syndrome genetic counseling, and they are based on clinical experience, review of pertinent English language articles, and reports of expert committees. These recommendations should not be construed as dictating an exclusive course of management, nor does use of such recommendations guarantee a particular outcome. The professional judgment of a health care provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations.     

A medical records managing and securing blockchain based system supported by a Genetic Algorithm and Discrete Wavelet Transform

The privacy of patients is jeopardised when medical records and data are spread or shared beyond the protected cloud of institutions. This is because breaches force them to the brink that they start abstaining from full disclosure of their condition. This type of condition has a negative effect on scientific research, patients and all stakeholders. A blockchain-based data sharing system is proposed to tackle this issue, which employs immutability and autonomy properties of the blockchain to sufficiently resolve challenges associated with access control and handle sensitive data. Our proposed system is supported by a Discrete Wavelet Transform to enhance the overall security, and a Genetic Algorithm technique to optimise the queuing optimization technique as well. Introducing this cryptographic key generator enhances the immunity and system access control, which allows verifying users securely in a fast way. This design allows further accountability since all users involved are already known and the blockchain records a log of their actions. Only when the users’ cryptographic keys and identities are confirmed, the system allows requesting data from the shared queuing requests. The achieved execution time per node, confirmation time per node and robust index for block number of 0.19 s, 0.17 s and 20 respectively that based on system evaluation illustrates that our system is robust, efficient, immune and scalable.     

Hybridized Indigenous Healing in the Kyrgyz Republic: Helping Survivors of Violence

ABSTRACT

Harmful consequences of civil unrest in 2010, in the Southern region of the Kyrgyz Republic in Osh, continue to have an impact on communities to the present day. One of the most significant effects has been numerous undiagnosed cases of rape and other types of gender-based violence (GBV) that occurred during the interethnic conflict. The true prevalence rate of GBV cases is still unknown. For example, according to official data from the Ministry of Internal Affairs (2011), there were only seven cases of rape during the conflict; however, crisis center reports documented 322 rapes (Molchanova, 2016 Molchanova, E. (2016). Okazanie psihologicheskoi pomoshci licam, postradavshim ot genderno-gonasiliya vo vremya krizisov i chrezvichainih situacii. Bishkek, Kyrgyz Republic: AltynPrint Publishing House.  [Google Scholar]). Cultural norms dictate that women who experience GBV hide their “shame,” which is why only a small percentage of victims with PTSD symptoms resulting from GBV seek out services from professionals, such as from crisis centers, psychologists and psychiatrists, and police. Indigenous healers are often the first and only stop for help-seeking. However, the influences of diverse religious beliefs and practices as well as the development of Western-style helping methods in the Kyrgyz Republic have shaped the practice of traditional healing. This hybridization, which is a process of including religious and even medical practices into traditional healing, started in the middle of the 1990s, and now, the extensive networks of traditional healers in the Kyrgyz Republic often combine traditional rituals with Islamic prayer, herbal treatment, massage, and other techniques. This article explores the hybridization of indigenous healing in the Kyrgyz Republic as a consequence of a variety of social transformations, and, as a result of polymorphism, the complexity and clinical variability of posttraumatic symptoms in Kyrgyz cultural settings.     

Engaging Australian Aboriginal youth in mental health services

It is currently estimated that up to 40% of Aboriginal youth (aged 13–17) will experience some form of mental health problem within their lifetime. Of greater concern is the evidence that indicates that Aboriginal youth fail to access mental health services commensurate with this need. This is due, in part, to the characteristically monocultural nature of service delivery of existing services. This paper overviews a model that has been developed specifically for the engagement of Aboriginal youth (aged 13–17 years) in mental health settings. Importantly, a mix of urban (N = 43) and rural (N = 68) Aboriginal youth were represented within the sample to determine its efficacy across different language and tribal groups. The model proved to be effective in engaging 97% of Aboriginal youth (n = 108), with only a small number not effectively engaged (n = 3). The model provides a foundation for the further development of evidence‐based models of best practice that have so far provided to be elusive within this complex field.