Anticipation across modalities in children and adults: Relating anticipatory alpha rhythm lateralization,reaction time,and executive function

The development of the ability to anticipate—as manifested by preparatory actions and neural activation related to the expectation of an upcoming stimulus—may play a key role in the ontogeny of cognitive skills more broadly. This preregistered study examined anticipatory brain potentials and behavioral responses (reaction time; RT) to anticipated target stimuli in relation to individual differences in the ability to use goals to direct action (as indexed by measures of executive function; EF). A cross-sectional investigation was conducted in 40 adults (aged 18–25 years) and 40 children (aged 6–8 years) to examine the association of changes in the amplitude of modality-specific alpha-range rhythms in the electroencephalogram (EEG) during anticipation of lateralized visual, tactile, or auditory stimuli with inter- and intraindividual variation in RT and EF. Children and adults exhibited contralateral anticipatory reductions in the mu rhythm and the visual alpha rhythm for tactile and visual anticipation, respectively, indicating modality and spatially specific attention allocation. Variability in within-subject anticipatory alpha lateralization (the difference between contralateral and ipsilateral alpha power) was related to single-trial RT. This relation was more prominent in adults than in children, and was not apparent for auditory stimuli. Multilevel models indicated that interindividual differences in anticipatory mu rhythm lateralization contributed to the significant association with variability in EF, but this was not the case for visual or auditory alpha rhythms. Exploratory microstate analyses were undertaken to cluster global field power (GFP) into a distribution-free temporal analysis examining developmental differences across samples and in relation to RT and EF. Anticipation is suggested as a developmental bridge construct connecting neuroscience, behavior, and cognition, with anticipatory EEG oscillations being discussed as quantifiable and potentially malleable indicators of stimulus prediction.     

A test of the hypothesis that Cronbach's alpha reliability coefficient is the same for two tests administered to the same sample

In measurement studies the researcher may wish to test the hypothesis that Cronbach's alpha reliability coefficient is the same for two measurement procedures. A statistical test exists for independent samples of subjects. In this paper three procedures are developed for the situation in which the coefficients are determined from the same sample. All three procedures are computationally simple and give tight control of Type I error when the sample size is 50 or greater.The author is indebted to Jerry S. Gilmer for development of the computer programs used in this study.     

创造力产生过程中的神经振荡机制

创造力究竟是怎么产生的, 目前尚未得出一致的结论。神经电生理技术因其高时间分辨率, 可以准确地揭示创造力产生进程中的神经振荡机制, 从而帮助人们更深刻地理解创造力的本质。近年来的研究发现, 单节律alpha神经振荡会随着创造力的增加而增强, 这反映了创造力产生过程中的内部信息加工需求增加、自上而下的抑制控制增强。同时, 多频段神经振荡交叉节律耦合体现了创造性产生过程中额叶、颞叶和顶叶等多脑区之间信息交流的动态变化。未来研究应该以整合理论框架为基础, 结合多层次多方法的研究工具, 引进更生态化的数理计算方法, 并利用计算神经科学建模来预测个体创造力发展趋势, 从而全面深刻地认识创造力的本质。     

Neuropharmacological aspects of adaptive pain inhibition in murine “victims” of aggression

This review outlines recent research on a subset of physiological responses in murine “victims” or aggression. In a typical resident-intruder paradigm, the detailed study of intruders has revealed that exposure to conspecific attack (and related stimuli) is associated with two forms of analgesia which appear to be integral components of the murine defensive repertoire. In response to intense/enduring attack, intruder mice display a profound, long-lasting and opioid-mediated analgesia. This reaction is highly correlated with defensive immobility and may function to reduce involuntary cues to further attack. In contrast, the inhibition of pain reactivity in mice tested immediately upon the display of defeat is less intense, shorter-lasting, non-opioid in nature and may function to facilitate active defenses such as escape. As this form of pain inhibition is also evident in intruders exposed to the scent of an aggressive male conspecific, a possible anticipatory defensive function linked to mechanisms of anxiety has been proposed. This hypothesis is supported by 1) the prevention of defeat analgesia by a range of antianxiety drugs (benzodiazepines, 5-hydroxytryptamine_1A [5-HT_1A] receptor agonists, and 5-HT₃ receptor antagonists) and 2) the effects of social defeat on behavior in the elevated plusmaze model of anxiety. These findings are discussed in relation to coping mechanisms in murine “victims” of aggression. © 1995 Wiley-Liss, Inc.     

未意识到错误影响错误后调整的电生理证据

现有研究一致认为意识到错误可引起错误后调整, 但是未意识到错误能否促使个体进行错误后调整尚存争议。本实验采用基于go/no-go范式的错误意识任务考察上述问题, 并根据被试对自己按键反应正误主观报告将no-go错误反应分为意识到错误和未意识到错误。行为结果发现, 意识到错误和未意识到错误后正确率均显著高于正确击中试次(正确go试次)后正确率; 但是, 意识到错误后试次反应时显著快于正确击中后反应时, 未意识到错误后反应时显著慢于正确击中后反应时。该结果表明两类错误均优化了错误后行为表现, 但是意识到错误后被试调整速度加快, 未意识到错误后被试调整速度减慢。进而, 时频分析发现意识到错误相较于未意识到错误诱发显著更强的alpha波能量。并且, 前者在错误意识主观报告前已诱发alpha波, 后者在错误意识主观报告反应后诱发alpha波。该结果表明意识到错误一直处于持续的注意监控中, 而未意识到错误是任务引起的暂时注意控制。因此, 本实验说明错误意识影响错误后调整, 意识到错误可能采用类似主动性控制的策略调节错误后行为, 而未意识到错误可能采用类似反应性控制的策略调节错误后行为。     

The role of instruction preference in analogy learning: Brain activity and motor performance

This study examined the role of verbal instruction preference when learning motor skills by analogy. During skill learning, analogies are a useful tool for providing knowledge about how to move. It has been argued that analogy instructions reduce reliance on verbal information processes during motor planning, compared to traditional forms of instruction (i.e., explicit rules about how to move). This may be reflected by reduced verbal activity in the brain, measured by EEG alpha power at the temporal region, as well as reduced verbal-motor cross-communication (EEG T7-Fz coherence) during the preparation phase of a movement. Preference for using verbal or visual instructions is likely to influence the efficacy of analogy instructions. This study investigated whether preference for verbal instructions was related to a) changes in performance and b) changes in verbal-cognitive information processing during performance of an adapted basketball task after instruction by analogy. Basketball novices with a high preference for verbal instructions (n = 15) showed significantly decreased activation of verbal brain regions when they used the analogy (high-alpha power), but their performance remained stable. Novices with a low preference for verbal instructions (n = 13) did not show a significant decrease in activation of verbal regions, and their performance deteriorated significantly after introduction of the analogy instruction. It is likely that both cognitive and performance changes after analogy instruction depend on personal aspects of information processing, such as verbal preference.     

Regulation of glutamate synapses by nicotinic acetylcholine receptors in auditory cortex

Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and functions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activation in auditory cortex and describe how these actions could affect systems-level auditory function. In particular, we describe a novel function of nicotinic acetylcholine receptors to regulate glutamate synapses containing N-methyl-D-aspartate receptors during early postnatal development. The transient regulation of developing glutamate synapses also defines a window of vulnerability during which exposure to exogenous nicotine disrupts synapse development. Thus, it appears that nicotinic regulation of glutamate synapses is a critical feature of auditory cortex development.     

Bion’s discovery of alpha function: Thinking under fire on the battlefield and in the consulting room

This paper has traced Bion’s discovery of alpha function and its subsequent elaboration. His traumatic experiences as a young tank commander in World War I (overlaid on, and intertwined with, childhood conflicts) gave him firsthand exposure to very painful emotions that tested his capacity to manage. Later, in the 1950s, after his analysis with Melanie Klein and marriage to Francesca Bion, he undertook the analysis of psychotic patients and learned how they disassembled their ability to know reality as a defense against unbearable emotional truths in their lives. This led Bion to identify an aspect of dreaming that was necessary in order for reality experience to be given personal meaning so that one may learn from experience. Simultaneous with working out this new theory of dreaming, Bion also revisited his World War I experiences that had remained undigested and all these elements coalesced into a selected fact – his discovery of alpha function. In subsequent writings, Bion explored the constituent factors of alpha function, including the container/contained relationship, the PS?D balance, reverie, tolerated doubt and other factors which I have termed the ‘Constellation for Thinking’.     

Cumulative estrogen exposure and prospective memory in older women

This study looked at cumulative lifetime estrogen exposure, as estimated with a mathematical index (Index of Cumulative Estrogen Exposure (ICEE)) that included variables (length of time on estrogen therapy, age at menarche and menopause, postmenopausal body mass index, time since menopause, nulliparity and duration of breastfeeding) known to influence estrogen levels across the life span, and performance on prospective and retrospective memory measures in a group of 50 postmenopausal women (mean age=69.3years) who, if they were current or former users of estrogen therapy, had started therapy within 5years of menopause. The ICEE was found to be a significant predictor of performance on the Prospective Memory task (F(1)=4.21, p=.046, η(p)(2)=.084). No significant relationship was noted between the ICEE and performance on measures of retrospective memory. The results suggest that the level of cumulative lifetime exposure to estrogen a woman has influences her prospective memory performance later in life and that the influence of reproductive and biological markers of endogenous estrogen exposure are relevant factors to consider when studying the effect of estrogen therapy on cognitive functioning in postmenopausal women. In addition, the finding that performance on a measure of prospective memory, but not performance on measures of retrospective memory, was associated with the ICEE adds further support to the theory that the frontal cortex may be especially sensitive to estrogen.