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Spatial learning and memory is preserved in rats after early development in a microgravity environment 总被引:1,自引:0,他引:1
This study evaluated the cognitive mapping abilities of rats that spent part of their early development in a microgravity environment. Litters of male and female Sprague-Dawley rat pups were launched into space aboard the National Aeronautics and Space Administration space shuttle Columbia on postnatal day 8 or 14 and remained in space for 16 days. These animals were designated as FLT groups. Two age-matched control groups remained on Earth: those in standard vivarium housing (VIV) and those in housing identical to that aboard the shuttle (AGC). On return to Earth, animals were tested in three different tasks that measure spatial learning ability, the Morris water maze (MWM), and a modified version of the radial arm maze (RAM). Animals were also tested in an open field apparatus to measure general activity and exploratory activity. Performance and search strategies were evaluated in each of these tasks using an automated tracking system. Despite the dramatic differences in early experience, there were remarkably few differences between the FLT groups and their Earth-bound controls in these tasks. FLT animals learned the MWM and RAM as quickly as did controls. Evaluation of search patterns suggested subtle differences in patterns of exploration and in the strategies used to solve the tasks during the first few days of testing, but these differences normalized rapidly. Together, these data suggest that development in an environment without gravity has minimal long-term impact on spatial learning and memory abilities. Any differences due to development in microgravity are quickly reversed after return to earth normal gravity. 相似文献
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Emotional states and physical health 总被引:30,自引:0,他引:30
Positive emotional states may promote healthy perceptions, beliefs, and physical well-being itself. To explore potential mechanisms linking pleasant feelings and good health, the authors consider several lines of research, including (a) direct effects of positive affect on physiology, especially the immune system, (b) the information value of emotional experiences, (c) the psychological resources engendered by positive feeling states, (d) the ways in which mood can motivate health-relevant behaviors, and (e) the elicitation of social support. As anticipated by the Greek physician Hippocrates, positive emotions and healthy outcomes may be linked through multiple pathways. 相似文献
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Robbie J. Steward Pamilla C. Morales Patricia A. Bartell Matthew Miller Dan Weeks 《Journal of multicultural counseling and development》1998,26(1):13-27
Findings suggest that the completion of or exposure to multicultural counseling coursework or literature does not necessarily indicate an acceptance of or valuing of multicultural counseling literature. Survey results of counselor trainees' observations and perceptions of peers whose perspectives on diversity differ are presented and discussed. Implications for training and supervision are addressed. 相似文献
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Steward WT Chandy S Singh G Panicker ST Osmand TA Heylen E Ekstrand ML 《Psychology, health & medicine》2011,16(1):74-85
Previous research has shown that HIV stigma in India can be characterized by a framework dividing manifestations into enacted (discrimination), vicarious (hearing stories of discrimination), felt normative (perceptions of stigma's prevalence), and internalized stigma (personal endorsement of stigma beliefs). We examined whether this framework could explain associations among stigma, efforts to avoid HIV serostatus disclosure, and depression symptoms in a cohort of 198 HIV-infected individuals from Southern India who were followed up for one year as part of a study of antiretroviral adherence. Prior studies had suggested that disclosure avoidance was a primary outcome of stigma and that impaired well-being was a primary outcome of disclosure avoidance. Analyses from our longitudinal research revealed that the pattern of associations among stigma, disclosure avoidance, and depression symptoms remained consistent over time. Enacted and vicarious stigmas were correlated with felt normative stigma beliefs. In turn, felt normative stigma was correlated with disclosure avoidance. And, enacted stigma, internalized stigma, and disclosure avoidance were all associated with depression symptoms. However, even though the overall framework held together, internalized stigma and depression symptoms dropped significantly over time while other components remained unchanged. These findings suggest that, although HIV stigma may limit disclosure, it does not invariably lead to psychological maladjustment. Amidst ongoing perceptions and experiences of stigma, HIV-positive individuals can achieve significant improvements in their acceptance of the disease and in mental well-being. 相似文献
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H. C. Steward 《Philosophical Studies》2006,130(3):535-563
The paper discusses one of the central arguments in Dennett’s Freedom Evolves, an argument designed to show that a deterministic universe would not necessarily be a universe of which it could truly be
said that everything that occurs in it is inevitable. It suggests that on its most natural interpretation, the argument is vulnerable to a serious objection. A second interpretation
is then developed, but it is argued that without placing more weight on etymological considerations than they can really bear,
it can deliver only a significantly qualified version of the conclusion that Dennett is seeking. Moreover, the new argument
depends upon an intermediate conclusion which, on the face of it, looks to be self-contradictory. Dennett is able to avoid
the appearance of self-contradiction only by utilising a possible-worlds framework for the understanding of “could have done
otherwise” judgements which is argued to be unsatisfactory. It is suggested that a different framework might hold the key
to understanding how better to defend these same judgements from purported threats from determinism. 相似文献
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This study examined 40 preschool children's understanding of the word touch. 24 drawings were presented one at a time to each child, and the children were instructed to describe each of the drawings and to classify them into drawings portraying touch or drawings showing no touch. 20 undergraduates were also interviewed. The same procedure was used, but in addition the undergraduates were asked to predict how preschool-age children would do on the same task. The results showed several ways in which the children's understanding of the word touch differed from that of an adult. 相似文献
10.
Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration
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Power AE Berlau DJ McGaugh JL Steward O 《Learning & memory (Cold Spring Harbor, N.Y.)》2006,13(1):27-34
Recent studies have reported new evidence consistent with the hypothesis that reactivating a memory by re-exposure to a training context destabilizes the memory and induces "reconsolidation." In the present experiments, rats' memory for inhibitory avoidance (IA) training was tested 6 h (Test 1), 2 d (Test 2), and 6 d (Test 3) after training. On Test 1 the rats were either removed from the shock compartment immediately after entry or retained in the shock context for 200 sec, and intrahippocampal infusions of the protein synthesis inhibitor anisomycin (75 microg/side) were administered immediately after the test. Anisomycin infusions administered after Test 1 impaired IA performance on Test 2 in animals given the brief re-exposure, but impaired extinction in animals exposed to the context for 200 sec. Rats with anisomycin-induced retention impairment on Test 2 demonstrated spontaneous recovery of retention performance on Test 3, whereas rats showing extinction on Test 2 showed further extinction on Test 3. The findings indicate that post-retrieval administration of anisomycin impairs subsequent retention performance only in the absence of extinction and that this impairment is temporary. 相似文献