Genetic Counseling Considerations in the Evaluation of Families for Lynch Syndrome��A Review

Lynch syndrome is the most common hereditary colorectal cancer syndrome and the most common cause of hereditary endometrial cancer. Identifying and evaluating families for Lynch syndrome is increasing in complexity due to the recognition that: family history-based clinical criteria lack sensitivity and specificity; genetic testing for Lynch syndrome continues to evolve as understanding of the molecular mechanisms underlying it evolves; and the Lynch syndrome phenotype encompasses multiple organ systems and demonstrates overlap with other hereditary cancer syndromes. This document is a summary of considerations when evaluating individuals and families for Lynch syndrome, including information on cancer risks, diagnostic criteria, tumor and genetic testing strategies, and the management of individuals with this condition.     

Identification of Individuals at Risk for Lynch Syndrome Using Targeted Evaluations and Genetic Testing: National Society of Genetic Counselors and the Collaborative Group of the Americas on Inherited Colorectal Cancer Joint Practice Guideline

Identifying individuals who have Lynch syndrome (LS) involves a complex diagnostic work up that includes taking a detailed family history and a combination of various genetic and immunohistochemical tests. The National Society of Genetic Counselors (NSGC) and the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA-ICC) have come together to publish this clinical practice testing guideline for the evaluation of LS. The purpose of this practice guideline is to provide guidance and a testing algorithm for LS as well as recommendations on when to offer testing. This guideline does not replace a consultation with a genetics professional. This guideline includes explanations in support of this and a summary of background data. While this guideline is not intended to serve as a review of LS, it includes a discussion of background information on LS, and cites a number of key publications which should be reviewed for a more in-depth understanding of LS. These guidelines are intended for genetic counselors, geneticists, gastroenterologists, surgeons, medical oncologists, obstetricians and gynecologists, nurses and other healthcare providers who evaluate patients for LS.     

Perfectionism and Interpersonal Sensitivity in Social Phobia: The Interpersonal Aspects of Perfectionism

We examined perfectionism, interpersonal sensitivity and dysfunctional cognitions in patients with Social Phobia (SP). The sample consisted of a clinical group with a diagnosis of SP (n?=?30) and a non clinical group (n?=?30), matched for age and gender. Both groups were assessed on Frost??s Multidimensional Perfectionism Scale (FMPS), Interpersonal Sensitivity Measure (IPSM), and Dysfunctional Attitudes Scale (DAS). The clinical sample was also assessed on Liebowitz Social Anxiety Scale (LSAS), Beck??s Depression Inventory-II, Eysenck??s Personality Inventory-Neuroticism sub-scale (EPI- N). The two groups were compared on FMPS, IPSM and DAS using t-test. Associations between FMPS, IPSM, DAS and predictors of social anxiety and depression were examined. The clinical group scored higher on perfectionism, interpersonal sensitivity and dysfunctional cognitions. There was no significant association between total scores on FMPS and IPSM. However subscales of IPSM and FMPS were correlated. Doubt about Actions was associated with Separation Anxiety (r?=?0.520) and Timidity (r?=?0.407). Organization was related to Interpersonal Awareness (r?=?0.371) and Separation Anxiety (r?=?0.407). Parental criticism was negatively associated with fragile inner self. DAS was positively correlated with FMPS and IPSM. Interpersonal sensitivity emerged as a significant predictor of social anxiety. Discriminant Functional Analysis indicated that concern over mistakes, organization, fragile inner self, separation anxiety discriminated between the clinical and non-clinical groups.     

The Relationship Between Learning Needs and Fatalism Tendency in Women Who Have a Relative with Breast Cancer

Journal of Religion and Health - The aim of this study was to determine the information-support needs and level of meeting these needs, the tendency of fatalism trend, and the relationship between...     

The dark side of bodybuilding: the role of bodybuilding activities in compensation of frustrated basic psychological needs

The main purpose of the current study was to investigate the explanatory mechanism of the drive for muscularity on the relations between frustrated basic needs and diverse indicators of muscle dysmorphia. To achieve this purpose, in the first place, as a pilot study needed to pursue the hypotheses of the main study, Basic Psychological Needs Satisfaction and Frustration Scale was adapted to Turkish and its psychometric properties were examined. In the main study, data were collected from 245 men with a mean age of 22.73 (SD = 3.86), who were engaged in regular bodybuilding activities. After the adaptation of Muscle Appearance Satisfaction Scale, the indirect predictive effects of frustrated basic needs on muscle dysmorphia symptoms through the drive for muscularity were examined via two structural equation models. Also, the moderating role of the drive for muscularity in the associations between each of the frustrated needs and muscle dysmorphia symptoms was tested via another structural equation model. Results revealed that (1) both the composite score of frustrated basic needs and frustrated relatedness are indirect predictors of all muscle dysmorphia symptoms through drive for muscularity and (2) drive for muscularity has a moderating role only in the relation between frustrated relatedness and muscle dissatisfaction (i.e., an indicator of muscle dysmorphia). These findings did not only support the assumptions of Self Determination Theory (SDT) indicating the link between frustrated needs and ill-being situations but also provided preliminary evidence for a new direction of SDT studies.