非小细胞肺癌 EG FR 基因突变检测与临床意义

采用荧光PCR法对199例晚期非小细胞肺癌（NSCLC ）组织进行表皮生长因子受体（EGFR ）基因突变检测,分析EGFR基因突变的分布特征及其与临床病理特征的相关性。结果显示56例（28．1％）存在EGFR基因突变,其中27例（13．6％）为外显子19突变,25例（12．6％）为外显子21突变,2例为外显子18突变,1例外显子20突变,1例外显子18和20的共突变。另外,除广东及安徽省铜陵市外,辽宁地区NSCLC患者EGFR基因突变率及主要突变类型与其他地区相符,常见于外显子19、21突变,其中腺癌、不吸烟患者突变率更高,更适宜EGFR-TKI靶向治疗。     

各种传统医学在高血压治疗中的应用

高血压痛作为最常见的慢性病,其并发症具有较高的致残率及致死率。本文综述近年来各种传统医学在高血压病治疗中的应用,包括传统中医对高血压痛的病因机的阐述,应用中药内服、外服、针灸等临床效果观察,蒙医辨证分型论治高血压病;藏医对高血压病的认识及临床采用的金针疗法治疗高血压病;壮医特色壮药内服,壮医药线点灸刺血疗法对高血压病的临床疗效评价。以此说明传统医药治疗方法对改善高血压病症状较明显,其治疗手段多样,副作用较小,降压效果平稳持久,有效减少并发症的优势。     

Predicting change in middle school students’ leisure-time physical activity participation: A prospective test of the trans-contextual model

We applied the trans-contextual model (TCM) to examine the effects of middle school students’ perceived autonomy support from their physical education (PE) teachers on autonomous motivation toward PE in school and, critically, autonomous motivation toward, and actual participation in, leisure-time physical activity (PA). The research adopted a three-wave prospective design enabling the modeling of change in the TCM constructs over time. Middle school students (N = 248) aged from 12 to 16 years reported their perceived autonomy support, autonomous motivation in PE, autonomous motivation toward leisure-time PA, attitudes, subjective norms, perceived behavioral control (PBC), intentions for PA in leisure-time, and leisure-time PA participation. The psychological constructs and leisure-time PA were measured at baseline (T0) and at a first follow-up occasion (T1) 5 weeks later. Another measure of PA was taken at a second follow-up occasion (T2) a further 5 weeks later. A single-indicator structural equation model using residualized change scores revealed that perceived autonomy support predicted autonomous motivation in PE (β = .345), and autonomous motivation in PE predicted autonomous motivation for leisure-time PA (β = .484). Autonomous motivation toward leisure-time PA predicted attitudes (β = .425), subjective norms (β = .264), and PBC (β = .517). Autonomous motivation toward leisure-time PA (β = .376), attitude (β = .231), and subjective norms (β = .185) predicted intentions toward leisure-time PA, and intentions predicted PA (β = .198). Findings extend research on the TCM by demonstrating its efficacy in predicting change in middle school students’ autonomous motivation across PE and leisure-time contexts, and accounting for change in intentions toward, and actual participation in, leisure-time PA.     

Is fat perception a thermal effect?

It has been generally assumed that fat is detected by its flavour and by its lubrication of the oral mucosa. A recent study reported a correlation of -.99 between perceived temperature of a product and its fat content. This was significantly higher than correlations of sensory scores for fat flavour, mouthfeel, and afterfeel. This suggested a third detection mechanism; fat may be detected via its effect on the thermal conductivity of the food. In 3 studies, thermal sensitivity in humans was investigated to verify whether oral thermal receptors are sufficiently rapid and accurate to play a role in the perception of fats. The thermal sensitivity of the lips and oral mucosa of the anterior and middle one-third of the tongue were assessed using a Peltier device. Subjects detected 0.5 Hz fluctuations in temperature of 0.08'C on the lower lip, 0.26 degrees C and 1.36 degrees C at the tip and dorsum of the tongue, demonstrating that the lips are sufficiently sensitive to detect small differences in temperature. In two further experiments subjects ingested custards and mayonnaises and then spat out samples after 5, 10, or 20 sec. The temperature of the food and oral mucosa was measured before and after spitting and the rates of heating were calculated. Results suggest assessment of thermal conductivity of food may be used to assess fat content.