Vagus nerve stimulation: a new form of therapeutic brain stimulation

Although the vagus nerve has traditionally been considered to perform efferent functions, in reality it performs significant afferent functions as well, carrying information from the body, head, and neck to the brain. Preliminary studies examining this afferent activity led to the theory that vagus nerve stimulation (VNS) could successfully control seizure activity in persons who are refractory to antiepileptic medications. Unlike other forms of brain stimulation, VNS is unable to directly stimulate multiple discrete areas of the brain; however, through several pathways, it is able to relay sensory information to higher brain regions. An implantable VNS device known as the VNSTM NeuroCybernetic Prosthesis (NCP) System has been used in approximately 9,000 epilepsy patients in Europe and the United States since 1994. The implant has reduced seizure frequency by an average of 25% to 30%, with minimal side effects. Studies underway are also showing some degree of success in the management of treatment-refractory depression. The future efficacy of the implantable system in other disorders may depend on whether the implant can be more precisely focused to affect different brain regions. Research in this area is underway.     

Task relevance modulates processing of distracting emotional stimuli

Numerous studies have claimed that emotional stimuli are able to capture attention automatically when presented outside the main focus of attention. In the current study this claim was tested by using task-relevant and task-irrelevant emotional stimuli. Specifically, in two experiments the effect of emotional stimuli presented in the periphery of attention was tested by using a flanker task. Results showed that emotional stimuli did not capture attention in an unconditional manner. Emotional distracting stimuli created interference only when they were relevant to the task. The findings suggest that "task relevance" is determined by (a) task requirements, and/or (b) target characteristics. The current results have implications for the concept of cognitive load and automaticity of processing emotional stimuli.     

Task-relevance modulates the effects of peripheral distractors

The current study investigated whether task-relevant information affects performance differently from how information that is not relevant for the task does when presented peripherally and centrally. In three experiments a target appeared inside the focus of attention, whereas a to-be-ignored distractor appeared either in the periphery (Experiments 1 and 2) or at the centre (Experiment 3) of attention. In each trial the distractor carried both task-relevant and irrelevant information. The results confirmed the “task relevance” hypothesis: Task-irrelevant information affected performance only when it appeared at the centre of attention, whereas task-relevant information affected performance when it appeared inside as well as outside the main focus of attention. The current results do not support suggestions that spatial stimuli (e.g., arrows) draw attention automatically regardless of task relevance.     

Prevalence and associated factors with body image dissatisfaction among adults in southern Brazil: A population-based study

We investigated the prevalence of body image dissatisfaction (BID) and associated factors in Florianopolis, Brazil. BID was analyzed in a sample (N = 1720) of adults through the Figure Rating Scale. The independent variables were sociodemographic factors, health behaviors, and morbidities. A multinomial logistic regression analysis was used. More men (14.2%) than women (6.1%) presented BID by being lighter than ideal (LI). Conversely, more women (66.6%) than men (46.3%) showed BID by being heavier than ideal (HI). BID by being HI was higher among older women, those with high BMI and those with a partner. In men, lower BMI and the presence of common mental disorders were associated with BID due to being LI. Advanced ages, alcohol abuse, physical inactivity, and obesity were associated with BID due to being HI. We must consider different public health interventions for men and women to reduce BID in Brazilian adults.     

Differing lateralized perceptual-motor patterns in schizophrenic and non-psychotic children

A neuropsychological assessment stressing lateralized perceptual-motor and cognitive abilities was administered to two groups of hospitalized child and adolescent psychiatric patients, 25 schizophrenics and 25 non-psychotics. The findings included an increased incidence of crossed eye-hand dominance in schizophrenics, poorer tactile sensory function in the right hands of schizophrenics than in the left hands, and lower Vocabulary and Similarities WISC subtest scores than Block Design and Object Assembly scores for schizophrenics. Right-left confusion was associated with finger agnosia for schizophrenics. The results supported the hypothesis that there may be left-hemisphere dysfunction in schizophrenia; however, no single pattern of dysfunction was apparent.     

How knowledge of regional brain dysfunction in depression will enable new somatic treatments in the next millennium

New knowledge about the specific brain regions involved in depression is rapidly evolving due to advances in functional neuroimaging techniques. Several new regionally specific somatic interventions build on this modern neuroanatomic information. These latest methods promise to revolutionize the understanding and treatment of depression. This article reviews the past and current use of these techniques, with an eye toward where they are heading in the next century.     

“It’s Scary but It’s Also Exciting”: Evidence of Meta-Affective Learning in Science

We study the case of Marya, a freshman engineering major who showed and spoke of a drastic shift in her feelings and approach to learning physics during an introductory course. For the first several weeks, she was anxiously manipulating equations without considering physical meaning, and she was terribly worried about being correct. By the end of the semester, however, she was sense-making and taking pleasure in it, showing and expressing an enjoyment of challenges and uncertainty. In this paper, we illustrate Marya’s transformation using data from her interview and coursework, and we propose it as an example of meta-affective learning. We argue that meta-affective learning was an important part of Marya’s physics learning and that it was deeply entangled with her developing epistemology.     

Mechanisms and the current state of transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) is unique among the current brain stimulation techniques because it is relatively non-invasive. TMS markedly differs from vagus nerve stimulation, deep brain stimulation and magnetic seizure therapy, all of which require either an implanted prosthesis or general anesthesia, or both. Since its rebirth in its modern form in 1985, TMS has already shown potential usefulness in at least three important domains-as a basic neuroscience research instrument, as a potential clinical diagnostic tool, and as a therapy for several different neuropsychiatric conditions. The TMS scientific literature has now expanded beyond what a single summary article can adequately cover. This review highlights several new developments in combining TMS with functional brain imaging, using TMS as a psychiatric therapy, potentially using TMS to enhance performance, and finally recent advances in the core technology of TMS. TMS' ability to non-invasively and focally stimulate the brain of an awake human is proving to be a most important development for neuroscience in general, and neuropsychiatry in particular.     

Women’s Experiences of Micro-Enterprise: Contexts and Meanings

The article confronts global claims of micro-enterprise to promote poverty reduction and gender equality. The article examines 60 in-depth interviews with low-income Palestinian and Israeli Jewish women (aged 25–45 years) who engaged in micro-enterprises. The research particularly focused on women’s motivations, personal qualities required for success, systemic barriers and opportunities, and women’s constructions of micro-enterprise as a means to overcome poverty and achieve gender equality. The article indicates that in the frame of gender and economic exclusionary context, without comprehensive institutional support, micro-enterprise and self employment may not promise more than a partial solution to poverty and gender discrimination. The article questions the tendency to globalize policies without taking into account the local contexts in which these policies are implemented.     

At-Risk Marriages after Compulsory Premarital Testing and Counseling for β-Thalassemia and Sickle Cell Disease in Saudi Arabia, 2005–2006

Results from a screening program for sickle cell disease and β-thalassemia suggest about 90% of couples in Saudi Arabia at risk of having affected children still decide to marry. This study determined the rate of at-risk marriages and identified several factors that may prevent at risk couples from marrying. The marriage status of 934 at-risk couples was determined from original screening program records in the Ministry of Health. Of 934 couples, 824 married (88.2%) and 110 (11.8%) did not. A case–controlled study was conducted on 104 couples who did not marry (cases) and 478 couples who did marry (controls) in order to assess relationships between various cultural and social factors and marriage decisions. In the case-controled study, 28.8% of couples (30/104) who did not marry (cases) knew their disease or carrier status before screening compared to 18% (86/478) of those who married (controls). Reasons couples gave for proceeding with marriage included: wedding plans could not be canceled, and fear of social stigma. Couples who did not marry reported being influenced by prior knowledge of their disease or carrier status and whether they or family members were affected. Approximately half of the cases and controls (n = 270, 46.4%) thought it best to undergo screening before proceeding with the engagement and wedding plans. Most couples received no advice to participate in genetic counseling services. Marriage decisions for the small number who received genetic counseling (n = 168, 27.6%) did not differ significantly from those that received no counseling. Recommendations are made for improving the effectiveness of this screening program.