Involvement of BDNF receptor TrkB in spatial memory formation

The N-methyl-D-aspartate (NMDA) receptors are involved in long-term potentiation (LTP), and are phosphorylated by several tyrosine kinases including a Src-family tyrosine kinase Fyn. Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which also enhances hippocampal synaptic transmission and efficacy by increasing NMDA receptor activity. Here, we show that Fyn is a key molecule linking the BDNF receptor TrkB with NMDA receptors, which play an important role in spatial memory formation in a radial arm maze. Spatial learning induced phosphorylation of TrkB, Fyn, and NR2B, but not NR2A, in the hippocampus. Fyn was coimmunoprecipitated with TrkB and NR2B, and this association was increased in well-trained rats compared with control animals. Continuous intracerebroventricular infusion of PP2, a tyrosine kinase inhibitor, in rats delayed memory acquisition in the radial arm maze, but PP2-treated animals reached the same level of learning as the controls. The phosphorylation of Fyn and NR2B, but not TrkB, was diminished by PP2 treatment. Our findings suggest the importance of interaction between BDNF/TrkB signaling and NMDA receptors for spatial memory in the hippocampus.     

Relationship between sports experience and executive function in 6–12‐year‐old children: independence from physical fitness and moderation by gender

The purpose of this study was to evaluate the relationship between sports experience (i.e., tennis experience) and executive function in children while controlling for physical activity and physical fitness. Sixty‐eight participants (6–12 years old, 34 males and 34 females) were enrolled in regular tennis lessons (mean = 2.4 years, range = 0.1–7.3 years) prior to the study. Executive functions, including inhibitory control (the Stroop Color‐Word Test), working memory (the 2‐back Task), and cognitive flexibility (the Local–global Task) were evaluated. Participants’ levels of daily physical activity, ranging from moderate to vigorous, were evaluated using triaxial accelerometers. The total score for physical fitness was assessed using the Tennis Field Test. Hierarchical multiple regression analyses revealed interaction effects between gender and tennis experience on participants’ reaction time (RT) on the switch cost of the Local–global Task after controlling for age, BMI, gender, physical activity, physical fitness, and tennis experience. Longer tennis experience was associated with shorter switch cost in males but not in females. Higher scores on physical fitness were positively associated with lower interference scores on the Stroop Color‐Word Test, RT on the 2‐back Task, and RT in the switching condition of the Local–global Task, after controlling for age, BMI, gender, and physical activity. In conclusion, all three foundational components of executive function (i.e., inhibitory control, working memory, and cognitive flexibility) were more strongly related to physical fitness than to physical activity in males and females, whereas greater cognitive flexibility was related to tennis experience only in the males.     

Spatial-attention and emotional evocation: line bisection performance and visual art emotional evocation

Lesion studies demonstrate that the right temporal-parietal region (RTP) is important for mediating spatial attention. The RTP is also involved in emotional experiences that can be evoked by art. Normal people vary in their ability to allocate spatial attention, thus, people who can better allocate attention might also be more influenced by the emotional messages of the paintings (evocative impact). Seventeen healthy participants bisected an unlabeled 100mm line and their performance on this task was used to create two groups, individuals who were more (mALB) and less accurate (lALB). These participants also judged 10 paintings on five qualities, Evocative Impact, Aesthetics, Novelty, Technique, and Closure by marking a 100mm line from 1 (low degree) to 10 (high degree). An ANOVA indicated differences in accuracy on the line bisection (LB) between the two groups. Additional ANOVAs, using the quality ratings as the dependent measure, revealed that the mALB group scored the Evocative Impact greater than the lALB group. These results suggest that the differences in attentional bias between the two groups, as indicated by their LB performance, might influence their evocative impact or reactions and also be a 'barometer' of other RTP functions, including emotional processing.     

career awareness of new graduates and recruiting activities by companies in japan

Japan has been experiencing a labor market problem wherein many young people are leaving their jobs within the first 3 years. The authors explore this situation and consider the role of career development in this process. Suggestions are made for how career development programs can play an important role in facilitating a more satisfying career transition process.     

On-line statistical segmentation of a non-speech auditory stream in neonates as demonstrated by event-related brain potentials

The ability to statistically segment a continuous auditory stream is one of the most important preparations for initiating language learning. Such ability is available to human infants at 8 months of age, as shown by a behavioral measurement. However, behavioral study alone cannot determine how early this ability is available. A recent study using measurements of event-related potential (ERP) revealed that neonates are able to detect statistical boundaries within auditory streams of speech syllables. Extending this line of research will allow us to better understand the cognitive preparation for language acquisition that is available to neonates. The aim of the present study was to examine the domain-generality of such statistical segmentation. Neonates were presented with nonlinguistic tone sequences composed of four tritone units, each consisting of three semitones extracted from one octave, for two 5-minute sessions. Only the first tone of each unit evoked a significant positivity in the frontal area during the second session, but not in the first session. This result suggests that the general ability to distinguish units in an auditory stream by statistical information is activated at birth and is probably innately prepared in humans.     

Psychosocial development and moral development: an exploratory comparison of adolescents in Japan and America

Building on previous cross-cultural research, this exploratory study examined the comparative psychosocial and sociomoral development of 46 adolescents--22 Japanese in Japan, 10 Japanese in the United States, and 14 Euro-Americans in the United States. Euro-American participants obtained more positive scores than Japanese in the United States and Japanese in Japan on six psychosocial stages and the total psychosocial score as measured by the Measures of Psychosocial Development. Except in the Contract/Truth domain, all groups scored at a comparable level in sociomoral development as measured by the Sociomoral Reflection Measure-Short Form. Results are discussed in terms of cultural differences affecting adolescent development with implications for research and professional practice.     

Masked semantic priming effects from the prime's orthographic neighbours

The present research involved masked priming lexical decision experiments using, in the crucial condition, masked primes with an orthographic neighbour that was semantically related to the target. Regardless of the lexicality of the prime, a significant priming effect was observed when the relatedness proportion (RP, that is, the proportion of primes and targets that were directly related on the “word” trials) was 2/3 (Experiments 1 and 2). No effect emerged, however, when the RP was 0 (Experiment 3). These results indicate that lexical/semantic activation arises automatically for both the prime and its neighbours. This activated lexical/semantic information appears to be evaluated together with the lexical/semantic information activated by the target, creating a decision bias during the decision-making process, but only when that information often provides a clue as to the nature of the correct decision. Our results, therefore, also provide support for the retrospective account of masked semantic priming.     

Effects of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance: comparison of horizontal and 6 degrees head-down bed rest

This study examined the effect of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance. Each of 7 volunteers were maintained for 3 days of head-down and horizontal bed rest in a counter-balanced design. Assessment measures were polysomnographic recordings on the first night and performance on psychophysiological tasks on the second day involving subjective and objective vigilance, P300, simple reaction time tasks, and dual performance tasks. No clear difference in sleep structure was observed between the head-down and horizontal conditions, except for a slight decrease in Stage 4 for head-down. Both subjective and objective daytime vigilance, P300, and the simple RT task showed no statistical difference, although tracking performance on the dual task showed deterioration at 10:00 for the head-down condition. These results suggest that nocturnal sleep, daytime vigilance, and psychophysiological functions were not disturbed in head-down sleep conditions, although there was a mild deterioration of higher attentional function in the morning.