Change in cognitive capabilities in the oldest old: the effects of proximity to death in genetically related individuals over a 6-year period

Change in cognitive abilities was assessed over a 6-year period in a sample of monozygotic and same-sex dizygotic twin pairs (N = 507 individuals), aged 80 and older (mean age = 83.3 years: SD = 3.1). who remained nondemented over the course of the study. Latent growth models (LGMs) show that chronological age and time to death are consistent predictors of decline in measures of memory, reasoning, speed, and verbal abilities. Multivariate LGM analysis resulted in weak and often negative correlations among rates of change between individuals within twin pairs, indicating greater differential change within twin pairs than occurs on average across twin pairs. These findings highlight several challenges for estimating genetic sources of variance in the context of compromised health and mortality-related change.     

Response reversals in recognition memory

Using a dynamic sequential sampling model and a recently proposed model for confidence judgments in recognition memory (T. Van Zandt, 2000b), the authors examine the tendency for rememberers to reverse their responses after a primary decision. In 4 experiments, speeded "old"-"new" decisions were made under bias followed by a 2nd response', either a confidence judgment or another simple choice. The data from these experiments showed that participants know when they have made a mistake and that they respond to this knowledge by reversing their responses. Response reversals are thus shown to be important for constructing models of the response-selection process in recognition memory.     

Engineering Values Into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility

Recent experiments have been used to “edit” genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing the Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a “gene drive” that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two examples of genetic engineering experiments.     

The Children's Apperception Test: Puzzle and Regular Form

To see whether more apperceptive responses could be elicited, the Children's Apperception Test (CAT) was used in a way which required the child to become motorically involved with the pictures. It was found that more children give significantly more apperceptive responses to a puzzle form of the CAT than to the regular form. Therefore, it was felt that the puzzle form was a more valuable instrument. It was suggested that any projective technique for very young children should be designed so that the response from the child results from his being actively involved in the situation.     

Describing organizations as reinforcer systems: A new use for job satisfaction and employee attitude surveys

Job satisfaction data on managerial personnel were used to illustrate how organizations can be differentiated and described as reinforcer systems. Twenty-seven specific satisfaction scales were regressed on overall job satisfaction, separately for each of five groups of managers from five organizations. For all groups, overall satisfaction was found to be determined mainly by scales concerning challenge of the job and prospects of one's chosen career. Application of decremental stepwise multiple regression procedures to obtain minimum-variable-set equations resulted in different, though overlapping, sets of variables in the equations for the different organizations. These results suggest a way of describing organizations as reinforcer systems, in terms of the specific determinants of overall satisfaction for the organization.     

Intraorganizational and interorganizational job change: A discriminant analysis

Using March and Simon's (1958) participation model as a framework, this study employs the 1973–77 Quality of Employment Survey panel data to compare the determinants of intraorganizational and interorganizational job change. Two discriminant functions were significant, the first distinguishing between intraorganizational changers and stayers and the second between interorganizational changers and stayers. Moreover, the variables that distinguished between intraorganizational changers and stayers were either different from or opposite in influence to those distinguishing between interorganizational changers and stayers.