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Natsuko Ikeda Shinichi Yamada Kasumi Yasuda Shinya Uenishi Atsushi Tamaki Takuya Ishida Michiyo Tabata Tomikimi Tsuji Sohei Kimoto Shun Takahashi 《Journal of Neuropsychology》2023,17(2):351-363
Cognitive impairment in schizophrenia and other psychiatric disorders is a challenge to be overcome in order to maintain patients' quality of life and social function. The neurological pathogenesis of cognitive impairment requires further elucidation. In general, the hippocampus interacts between the cortical and subcortical areas for information processing and consolidation and has an important role in memory. We examined the relationship between structural connectivity of the hippocampus and cortical/subcortical areas and cognitive impairment in schizophrenia, major depressive disorder and bipolar disorder. Subjects comprised 21 healthy controls, 19 patients with schizophrenia, 20 patients with bipolar disorder and 18 patients with major depressive disorder. Diffusion-weighted tensor images data were processed using ProbtrackX2 to calculate the structural connectivity between the hippocampus and cortical/subcortical areas. Cognitive function was assessed using the Brief Assessment of Cognition in schizophrenia composite score. Hippocampal structural connectivity index was significantly correlated with composite score in the schizophrenia group but not in the healthy control, major depressive disorder or bipolar disorder groups. There were no statistically significant differences in hippocampal structural connectivity index between the four groups. Structural connectivity between the hippocampus and cortical/subcortical areas is suggested to be a pathophysiological mechanism of comprehensive cognitive impairment in schizophrenia. 相似文献
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Noriko Nitta Eiji Taguchi Hidehiro Yasuda Hidetaro Mori Yoshihiko Hayashi Toshimasa Yoshiie 《Philosophical Magazine Letters》2013,93(3):223-228
Secondary defects induced by ion and electron irradiation up to 6?dpa (displacements per atom) at liquid-nitrogen temperature in GaSb thin films are compared. For Sn ion (60?keV) irradiation, voids were observed. However, for high-energy electron (2?MeV) irradiation, interstitial-type dislocation loops were produced. The densities of voids and interstitial-type dislocation loops were almost equivalent (8?×?1014?voids/m2 and 3?×?1014?loops/m2) after irradiations at the same damage level of 6?dpa. It is concluded that the formation of voids by ion irradiation follows the creation of localised vacancy defects in cascade damage. 相似文献
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To examine whether anticipatory attention or expectancy is a cognitive process that is automatic or requires conscious control, we employed a paired-stimulus event-related potential (ERP) paradigm during the transition to sleep. The slow negative ERP wave observed between two successive stimuli, the Contingent Negative Variation (CNV), reflects attention and expectancy to the second stimulus. Thirteen good sleepers were instructed to respond to the second stimulus in a pair during waking sessions. In a non-response paradigm modified for sleep, participants then fell asleep while tones played. As expected, N1 decreased and P2 increased in amplitude systematically with the loss of consciousness at sleep onset; the CNV was increasingly more positive. Sleep onset latency was correlated with the amplitude of the CNV. The systematic attenuation of the CNV waveform at sleep onset and its absence in sleep indicates that anticipatory attention requires endogenous conscious control. 相似文献
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We have previously reported that sound sequence discrimination learning requires cholinergic inputs to the auditory cortex (AC) in rats. In that study, reward was used for motivating discrimination behavior in rats. Therefore, dopaminergic inputs mediating reward signals may have an important role in the learning. We tested the possibility in the present study. Rats were trained to discriminate sequences of two sound components, and licking behavior in response to one of the two sequences was rewarded with water. To identify the dopaminergic inputs responsible for the learning, dopaminergic afferents to the AC were lesioned with local injection of 6-hydroxydopamine (6-OHDA). The injection attenuated sound sequence discrimination learning, while it had no effect on discrimination between the sound components of the sequence stimuli. Local injection of 6-OHDA into the nucleus accumbens attenuated sound discrimination learning. However, not only discrimination learning of sound sequence but also that of the sound components were impaired. SCH23390 (0.2 mg/kg, i.p.), a D1 receptor antagonist, had no effect on sound sequence discrimination learning, while it attenuated the licking behavior to unfamiliar stimuli. Haloperidol (0.5 mg/kg, i.p.), a D2 family antagonist, attenuated sound sequence discrimination learning, while it had no clear suppressive effect on discrimination of two different sound components and licking. These results suggest that D2 family receptors activated by dopaminergic inputs to the AC are required for sound sequence discrimination learning. 相似文献
5.
Machery Edouard Stich Stephen Rose David Alai Mario Angelucci Adriano Berniūnas Renatas Buchtel Emma E. Chatterjee Amita Cheon Hyundeuk Cho In-Rae Cohnitz Daniel Cova Florian Dranseika Vilius Lagos Ángeles Eraña Ghadakpour Laleh Grinberg Maurice Hannikainen Ivar Hashimoto Takaaki Horowitz Amir Hristova Evgeniya Jraissati Yasmina Kadreva Veselina Karasawa Kaori Kim Hackjin Kim Yeonjeong Lee Minwoo Mauro Carlos Mizumoto Masaharu Moruzzi Sebastiano Olivola Christopher Y. Ornelas Jorge Osimani Barbara Romero Carlos Lopez Alejandro Rosas Sangoi Massimo Sereni Andrea Songhorian Sarah Sousa Paulo Struchiner Noel Tripodi Vera Usui Naoki del Mercado Alejandro Vázquez Volpe Giorgio Vosgerichian Hrag Abraham Zhang Xueyi Zhu Jing 《印度哲学研究理事会杂志》2017,34(3):517-541
Journal of Indian Council of Philosophical Research - This article examines whether people share the Gettier intuition (viz. that someone who has a true justified belief that p may nonetheless fail... 相似文献
6.
David Rose Edouard Machery Stephen Stich Mario Alai Adriano Angelucci Renatas Berninas Emma E. Buchtel Amita Chatterjee Hyundeuk Cheon In‐Rae Cho Daniel Cohnitz Florian Cova Vilius Dranseika ngeles Eraa Lagos Laleh Ghadakpour Maurice Grinberg Ivar Hannikainen Takaaki Hashimoto Amir Horowitz Evgeniya Hristova Yasmina Jraissati Veselina Kadreva Kaori Karasawa Hackjin Kim Yeonjeong Kim Minwoo Lee Carlos Mauro Masaharu Mizumoto Sebastiano Moruzzi Christopher Y. Olivola Jorge Ornelas Barbara Osimani Carlos Romero Alejandro Rosas Lopez Massimo Sangoi Andrea Sereni Sarah Songhorian Paulo Sousa Noel Struchiner Vera Tripodi Naoki Usui Alejandro Vzquez del Mercado Giorgio Volpe Hrag Abraham Vosgerichian Xueyi Zhang Jing Zhu 《No?s (Detroit, Mich.)》2019,53(1):224-247
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The Somatomorphic Matrix (SM) is a computer-based body image assessment program that allows assessment of the individual's body image in relation to known body composition values. To date, no study has compared the SM results to the measured body composition and assessed the usefulness in multi-ethnic samples. Japanese and Australian Caucasian males underwent testing to examine the SM body image results to their measured body composition. Japanese males showed significant (p < 0.01) discrepancy in their measured and the perceived ‘current’ muscularity compared with Australians. Both groups showed wide variability in the perception of their ‘current’ body composition in relation to the measured values, indicating an incomparability of the SM results to the measured results. The study also showed Japanese males to have lower consistency in the SM results than Australian males after a 12-month interval. In order to use the program in multi-ethnic populations further development of the program is recommended. 相似文献
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The present study investigated aphasic subjects' ability to comprehend and store serially presented discourse. Sixteen mild aphasic subjects, eight age-matched normals, and eight younger normals listened to four serially presented radio news stories and a single radio news story. Half of the aphasic subjects performed as well as age-matched normals in a single-news-story comprehension task. However, they demonstrated a drastic deterioration in performance when asked to listen to a series of four news stories. Age-matched normals, and aphasic subjects, to a lesser extent, showed an impairment in the comprehension and storage of the news story heard last in a series of four news stories. These results were discussed in terms of the comprehension and storage resources of working memory. 相似文献
10.
“Retrieval-induced forgetting” in rats was evaluated using a modified spontaneous object recognition test. The test consisted of a sample phase, retrieval or interference phase, and a test phase with 60-min delay period inserted between the phases. Rats were randomly assigned to one of three groups (control, retrieval and interference) and allowed to explore the field in which two different objects (A, B) were placed in the sample phase. In the retrieval phase, two identical objects (B, B), which were the same as one of the objects presented in the sample phase, were placed again. In the interference phase, two identical objects (C, C), which were novel for animals, were placed. In the test phase, two different objects (A, D), one of which was identical to that presented in sample phase (familiar object) and the other was novel, were placed and the time spent exploring each object was analyzed. While the exploration of the novel object was significantly longer than that of the familiar object in rats subjected to the interference phase, rats subjected to the retrieval phase could not discriminate between the familiar and the novel objects at the test phase. These results demonstrate the “retrieval-induced forgetting” phenomenon in a spontaneous object recognition test in rats. 相似文献