Memory deficits in Alzheimer's patients: A comprehensive review

Despite considerable experimental work on Alzheimer's disease (AD), the underlying cognitive mechanisms as well as the precise localization of neuropathological changes critical for memory loss remains undefined. A review of the neuropsychological literature on long-term memory deficits in AD patients suggests that AD patients display (a) a pervasive deficit of explicit memory, (b) a partial deficiency of implicit memory for verbal and visuoperceptual material (as measured by repetition priming procedures), and (c) a substantial sparing of implicit memory for visuomotor skills. The explicit memory loss is likely a result of encoding as well as consolidation difficulties. A faulty lexical-semantic knowledge structure appears responsible for deficient repetition priming effects. Since neuropathological changes diffusely affect the brain of AD patients, establishing a clear relationship between localization of cerebral lesions and memory deficits is particularly difficult. Nevertheless, data suggest that extensive involvement of the hippocampal-amygdala complex plays a major role in explicit memory loss. Damage to associative cortical areas likely is involved in repetition priming deficits. The relative integrity of primary motor and sensory cortical areas and of the basal ganglia likely subsume, by contrast, the normal learning of visuomotor skills.     

Parent-tutoring procedures: Experimental analysis and validation of generalization in oral reading across passages,settings, and time

A study that involved parents as reading tutors was carried out at home during the summer with four elementary children, three with learning disabilities. One purpose was to determine the effects of tutoring in the basal reader on reading rates at home. Another purpose was to determine potential generalization effects as a result of parent tutoring on different academic tasks at home and, later at school, on different and similar tasks. A combination multiple-baseline and reversal design tested for replication and generalization effects. Increases in correct rates were noted for the targeted variables across conditions. The results indicated that parents tutoring with school basal texts during the summer produced marked increases in reading rates that generalized at home to different academic tasks and at school to different and similar tasks. This suggests that parents, when using specific tutoring procedures, can increase their children's academic skills.     

How infant-directed actions enhance infants’ attention,learning, and exploration: Evidence from EEG and computational modeling

When teaching infants new actions, parents tend to modify their movements. Infants prefer these infant-directed actions (IDAs) over adult-directed actions and learn well from them. Yet, it remains unclear how parents’ action modulations capture infants’ attention. Typically, making movements larger than usual is thought to draw attention. Recent findings, however, suggest that parents might exploit movement variability to highlight actions. We hypothesized that variability in movement amplitude rather than higher amplitude is capturing infants’ attention during IDAs. Using EEG, we measured 15-month-olds’ brain activity while they were observing action demonstrations with normal, high, or variable amplitude movements. Infants’ theta power (4–5 Hz) in fronto-central channels was compared between conditions. Frontal theta was significantly higher, indicating stronger attentional engagement, in the variable compared to the other conditions. Computational modelling showed that infants’ frontal theta power was predicted best by how surprising each movement was. Thus, surprise induced by variability in movements rather than large movements alone engages infants’ attention during IDAs. Infants with higher theta power for variable movements were more likely to perform actions successfully and to explore objects novel in the context of the given goal. This highlights the brain mechanisms by which IDAs enhance infants’ attention, learning, and exploration.     

Evaluation of visual display surfaces by real users early in the design stage

Groups of non-computer scientists were tested to evaluate the potential of an as yet non-existent interactive terminal with a screen diagonal of one meter. A simulated large image terminal provided limited realistic interactions using software developed to give close proximity to the predicted visual effect. Subjective responses from 101 subjects were elicited from a questionnaire designed to evaluate specific aspects of the “terminal” in use. From this data, two types of screen (lenticular and plain) and two types of interaction devices (touch and remote pointer) were analyzed experimentally using a two-way factorial design. Potential end-users provided positive feedback concerning future use of the Large Image Terminal. Building a realistic mock-up revealed screen contaminations which would not have been discovered until a much later stage. Although statistical analysis of screen evaluations was equivocal, the questionnaire was sufficiently penetrating to separate the positive and negative features. This methodology was invaluable in guiding the design process. Copies of the questionnaire may be obtained from the authors at the Heriot-Watt address.     

Supervising the person of the therapist: Issues,challenges and dilemmas

A major critical issue in marriage and family therapy today is the professionalization of the discipline. Thus the focus on training individuals for a career in marriage and family therapy necessitates the revisitation of the debate over personal growth versus skill development. The trend toward training the person of the therapist, however, would suggest that the field is moving toward the integration of self awareness and skill in the therapeutic system. With the popularization of training the person of the therapist comes other issues, challenges, and dilemmas for the field, including the crucial issue of training gender and culturally sensitive therapists. The potential for creating dual relationships when training the person of the therapist is both a dilemma and a challenge.     

Selective delayed alternation deficits in dominantly inherited olivopontocerebellar atrophy

In order to characterize more completely the nature of the frontal lobe-type cognitive changes in patients with dominantly inherited olivopontocerebellar atrophy (OPCA) we administered two tasks sensitive to frontal system dysfunction, delayed alternation (DA) and delayed response (DR), to 12 patients from one OPCA family. Affected members from this family have previously been shown to have a marked and widespread cerebral (including frontal) cortical cholinergic reduction as severe as that observed in Alzheimer's disease. Performance on DA, but not on DR, was significantly impaired in the OPCA patients compared to that in the controls. We suggest that the DA deficits in OPCA could be a consequence of a loss of cholinergic innervation to orbitofrontal or possibly temporal cortical areas and/or damage to the integrity of the cerebello-frontal neuronal connections.     

A feminist's look at freud's feminine psychology

The psychology of women is admittedly incomplete and fragmentary, and sometimes it does not sound altogether flattering. You must not forget, however, that we have only described women in so far as their natures are determined by their sexual function. The influence of this factor is, of course, very far-reaching, but we must remember that an individual woman may be a human being apart from this. If you want to know more about feminity, you must interrogate your own experience, or turn to the poets, or else wait until Science can give you more profound and more coherent information.     

Network Structure of Callous-Unemotional Traits and Conduct Disorder Symptoms Among At-Risk Youth: Multi-Informant Reports and Gender Differences

Research on Child and Adolescent Psychopathology - Network analytic techniques examine how items used to measure underlying constructs are related to one another and identify core characteristics....     

Epistemological beliefs and thinking about everyday controversial issues

The authors investigated the relationship between individuals' beliefs about the nature of knowledge and the nature of learning (epistemological beliefs) and their thinking about everyday controversial issues. Adults (N = 174) ranging in age from 17 to 71 years old with a mean age of 38 completed the Schommer Epistemological Questionnaire (M. Schommer, 1990), which assessed their beliefs in the certainty and organization of knowledge and the speed and control of learning. After they had completed the questionnaire, they responded to a series of questions about two controversial issues that had been discussed in the local newspaper. Regression analyses indicated that the more the participants believed in complex and tentative knowledge, the more likely they were to take on multiple perspectives, be willing to modify their thinking, withhold ultimate decisions until all information was available, and acknowledge the complex, tentative nature of everyday issues. Epistemological beliefs that are heavily influenced by a higher level of education appear to relate to thinking beyond the classroom, and introducing controversial issues into the curriculum may reciprocally foster the development of epistemological beliefs.     

To stay or to go, to speak or stay silent, to act or not to act: moral distress as experienced by psychologists

The moral distress of psychologists working in psychiatric and mental health care settings was explored in an interdisciplinary, hermeneutic phenomenological study situated at the University of Alberta, Canada. Moral distress is the state experienced when moral choices and actions are thwarted by constraints. Psychologists described specific incidents in which they felt their integrity had been compromised by such factors as institutional and interinstitutional demands, team conflicts, and interdisciplinary disputes. They described dealing with the resulting moral distress by such means as silence, taking a stance, acting secretively, sustaining themselves through work with clients, seeking support from colleagues, and exiting. Recognizing moral distress can lead to a significant shift in the way we perceive moral choices and understand the moral context of practice.