Dkk-1蛋白的研究现状、进展及临床意义

Dkk(Dickkopf)是Wnt信号通路中重要的拮抗因子之一,通过与Wnt受体复合体LRP5/6结合来抑制Wnt信号通路.Dkk-1在代谢性骨病(骨质疏松症Paget病)、多种癌症、骨关节炎等疾病中都存在着异常表达并起到重要作用.本文将对现有的Dkk-1基因的研究进展进行总结,并对Dkk-1基因的研究意义进行了展望.     

大鼠作业成绩与脑内亮氨酸脑啡肽含量变化的相关性研究

本工作采用穿梭式电击回避反应法和脑啡肽的放射免疫测定法,分析比较了大鼠作业成绩与脑内壳氨酸脑啡肽(Leu-enkephalin,LEK)含量的关系,在本实验条件下,观察到作业成绩不良组纹状体内LEK含量显著高于成绩优良组和对照组,并由实验证明,它们之间的差异不是由于在实验中接受电击的次数或电击总量不同造成的。这一结果提示,内源性亮氨酸脑啡肽可能参与记忆获得的调制。     

Parent and child adjustment dual trajectories at the beginning of the COVID-19 syndemic

Children and their families have been significantly impacted by the unfolding of the COVID-19 syndemic. We sought to identify (1) groups of families with distinct profiles of joint trajectories of parental anxiety and child emotional distress and (2) protective and risk factors associated with these dual-trajectory profiles. A sample of 488 parents (65% White; 77% mothers) with 3- to 8-year-old children (M_Age = 5.04, SD_Age = 1.59) was followed from late March to early July in 2020. Survey data on parent (i.e., anxiety symptoms) and child (i.e., emotional distress) adjustment were collected at three time points. Using multivariate growth mixture modeling, we identified one group with low parental anxiety and child emotional distress (42.7%) and three other distinct groups with varying risk levels among parents and/or children. We also identified protective (e.g., positive parenting) and risk (e.g., child negative affect, negative parenting, perceived stress with racism) factors in predicting parent and child adjustment. It can be concluded that, overall, our sample (mostly middle- and high-socioeconomic status families) demonstrated family resilience amid COVID-19, consistent with prior disaster coping literature. At the same time, our findings also indicated the need to identify at-risk families and modifiable factors for post-disaster public health interventions.     

被动性社交网站使用与青少年体像烦恼的关系:体像比较和体像自我差异的中介作用

为探讨被动性社交网站使用和青少年体像烦恼的关系,基于社会比较理论和自我差异理论,采用被动性社交网站使用问卷、社交网站体像比较量表、理想体像问卷和体像烦恼量表,对789名初、高中生进行调查。结果表明：（1）被动性社交网站使用对青少年体像烦恼具有显著的正向预测作用;（2）体像比较和体像自我差异能在被动性社交网站使用和体像烦恼的关系中起中介作用;（3）在被动性社交网站使用与体像烦恼的关系中,女生的体像比较和体像自我差异起并行中介作用,而对男生而言,体像比较和体像自我差异起链式中介作用。研究结果表明被动性社交网站使用不仅能直接影响青少年的体像烦恼,还可通过体像比较和体像自我差异的间接作用对青少年体像烦恼产生影响,且中介路径存在性别差异。     

入手术室时的情绪状态和某些心理、生理机能的联系及其和针麻效果的关系

情绪活动和某些生理机能或心理过程的关系很久以来就已进行过大量的研究。外科手术前患者的情绪状态及其相应的生理机能的变化,也曾受到注意。患者在意识清醒状态下进行针麻手术,他的情绪状态对针麻过程及其效果的作用如何,这种情绪状态和某些心理、生理机能有什么联系?这是针麻临床上和理论上应予探讨的问题之一。本工作试图综合分析患者的情绪状态和与之伴随的某些生理生化指标变化,以探讨     

被动性社交网站使用与青少年体像烦恼的关系:体像比较和体像自我差异的中介作用

为探讨被动性社交网站使用和青少年体像烦恼的关系,基于社会比较理论和自我差异理论,采用被动性社交网站使用问卷、社交网站体像比较量表、理想体像问卷和体像烦恼量表,对789名初、高中生进行调查。结果表明：（1）被动性社交网站使用对青少年体像烦恼具有显著的正向预测作用;（2）体像比较和体像自我差异能在被动性社交网站使用和体像烦恼的关系中起中介作用;（3）在被动性社交网站使用与体像烦恼的关系中,女生的体像比较和体像自我差异起并行中介作用,而对男生而言,体像比较和体像自我差异起链式中介作用。研究结果表明被动性社交网站使用不仅能直接影响青少年的体像烦恼,还可通过体像比较和体像自我差异的间接作用对青少年体像烦恼产生影响,且中介路径存在性别差异。     

Individual Differences in Categorization Gradience As Predicted by Online Processing of Phonetic Cues During Spoken Word Recognition: Evidence From Eye Movements

Recent studies have documented substantial variability among typical listeners in how gradiently they categorize speech sounds, and this variability in categorization gradience may link to how listeners weight different cues in the incoming signal. The present study tested the relationship between categorization gradience and cue weighting across two sets of English contrasts, each varying orthogonally in two acoustic dimensions. Participants performed a four-alternative forced-choice identification task in a visual world paradigm while their eye movements were monitored. We found that (a) greater categorization gradience derived from behavioral identification responses corresponds to larger secondary cue weights derived from eye movements; (b) the relationship between categorization gradience and secondary cue weighting is observed across cues and contrasts, suggesting that categorization gradience may be a consistent within-individual property in speech perception; and (c) listeners who showed greater categorization gradience tend to adopt a buffered processing strategy, especially when cues arrive asynchronously in time.     

参照依赖和损失规避对个体收入分配公平判断的影响

收入分配公平判断是人们对自己收入所得公平与否的主观评价。通过对参照点和收入金额的控制,探讨参照依赖和损失规避对收入分配公平判断的共同影响。结果发现,(1)民众的收入公平判断受参照点的影响,在有参照点的情景下比无参照点情景下更感觉不公平;(2)不同工资水平下,民众的公平判断具有显著差异,而且民众对低于平均工资的“受损”比高于平均工资同等金额的“受益”赋予的公平感的权重更大,即存在得失感受的不对称;(3)不同的工资参照点、多得和少得的分配结果共同影响民众的公平判断,即损失规避在参照依赖对公平判断的影响中起调节作用。     

王时槐思想中恶的问题

王时槐是江右王学的代表性人物之一,他将善恶视为念能否顺本性而动,对合法性与道德性有清楚的辨析,并注重过恶之辨,意念无明显的邪妄可以视为无恶,但不代表无过。他主张善有本体,而恶无根即无形上的本体,但恶仍有其根源,这就是人的"自离其性"或"甘自弃之"的主观条件,这与康德的根本恶学说可以接榫。王时槐强调改过迁善的根本动力或力量源于自身,他主张人要立志、修治与敦礼,旨在实现心灵转变与在感官方式上的逐渐改良,达到念念归根的状态,从而纠正准则中颠倒的道德动机的顺序,他对静坐的强调则是通过收敛与暂息尘缘,以默识自心,从而达到动静皆能复归本性。     

权力感对道德困境判断的影响：基于CNI模型的分析

采用道德困境判断的CNI（consequence, norm, inaction）模型,通过两个实验考察权力感对道德困境判断的影响。实验1探讨个人权力感对道德困境判断的影响,结果显示高个人权力感显著增加被试对规则的敏感,促使个体做出道义论的道德判断。实验2考察回忆任务启动的权力感对道德困境判断的影响,发现相对于低权力感启动的被试,高权力感启动的被试在进行判断时更关注行为的结果,对规则更不敏感,这说明启动的权力感促进功利主义的道德判断,抑制道义论的道德判断。结果表明,不同类型的权力感对道德困境判断的影响存在差异。