Traditional Roles in a Non-Traditional Setting: Genetic Counseling in Precision Oncology

Next generation sequencing technology is increasingly utilized in oncology with the goal of targeting therapeutics to improve response and reduce side effects. Interpretation of tumor mutations requires sequencing of paired germline DNA, raising questions about incidental germline findings. We describe our experiences as part of a research team implementing a protocol for whole genome sequencing (WGS) of tumors and paired germline DNA known as the Michigan Oncology Sequencing project (MI-ONCOSEQ) that includes options for receiving incidental germline findings. Genetic counselors (GCs) discuss options for return of results with patients during the informed consent process and document family histories. GCs also review germline findings and actively participate in the multi-disciplinary Precision Medicine Tumor Board (PMTB), providing clinical context for interpretation of germline results and making recommendations about disclosure of germline findings. GCs have encountered ethical and counseling challenges with participants, described here. Although GCs have not been traditionally involved in molecular testing of tumors, our experiences with MI-ONCOSEQ demonstrate that GCs have important applicable skills to contribute to multi-disciplinary care teams implementing precision oncology. Broader use of WGS in oncology treatment decision making and American College of Medical Genetics and Genomics (ACMG) recommendations for active interrogation of germline tissue in tumor-normal dyads suggests that GCs will have future opportunities in this area outside of research settings.     

Young Deceivers: Executive Functioning and Antisocial Lie‐telling in Preschool Aged Children

The present study examined the emergence of antisocial lie‐telling in very young children. Lie‐telling was studied in relation to executive functioning skills and children's abilities to identify both truths and lies. A total of 65 children (M_{age in months} = 31.75, SD = 1.87) participated in a modified temptation resistance paradigm (TRP; designed to elicit spontaneous lies). Executive functioning was measured through an inhibitory control task and a forward search planning task. The Truth/Lie Identification task was administered (Lyon, Carrick, & Quas, 2010 ) to measure children's abilities to accurately distinguish truths and lies. During the TRP, a total of 89.23% children peeked at the toy when a research assistant left the room, and of those children, 29.31% lied to the research assistant. Significant differences on executive functioning measures were found between lie‐tellers and confessors, as well as for the Truth/Lie Identification task. Lie‐tellers had higher scores on measures of inhibitory control and forward search planning. Lie‐tellers also had higher accuracy on the Truth/Lie Identification task than confessors. This study provides a unique contribution to the literature by examining 2.5‐year‐old children's emerging lie‐telling abilities, a relatively understudied age during which fledgling lie‐telling emerges. Copyright © 2016 John Wiley & Sons, Ltd.     

An exploratory analysis of the contexts and circumstances of filicide‐suicide in Chicago, 1965–1994

Filicide is the killing of a ward by a parent. Relative to many other types of homicide, filicide is an infrequent event. Filicide followed by the offender's suicide is less frequent still. The contexts and circumstances surrounding filicide‐suicide may nevertheless provide insight into parental psychology. Some research suggests, for example, that filicidal genetic parents are more likely to commit suicide than are filicidal stepparents. Five hypotheses are tested for this study, using a database that includes incident‐level information on over 22,000 homicides committed in Chicago during the years 1965–1994. Findings do not support the hypothesis of differential risk of suicide following filicide by genetic parents and stepparents. Previous work is replicated, indicating that: (1) filicides that include multiple victims are more likely to end in the offender's suicide than are filicides that include a single victim, (2) parents are more likely to commit suicide following a filicide of an older child than a filicide of a younger child, (3) older parents, relative to younger parents, are more likely to commit suicide following filicide, and that (4) fathers, relative to mothers, are more likely to commit suicide following filicide. Discussion suggests future directions for research that can inform our understanding of filicide and of filicide‐suicide. Aggr. Behav. 00:000–000, 2005. © 2005 Wiley‐Liss, Inc.     

Ageing and bilingualism: absence of a "bilingual advantage" in stroop interference in a nonimmigrant sample

Previous research has found an advantage for bilinguals relative to monolinguals on tasks of attentional control. This advantage has been found to be larger in older adults than in young adults, suggesting that bilingualism provides a buffer against age-related declines in executive functioning. Using a computerized Stroop task in a nonimmigrant sample of young and older monolinguals and bilinguals, the current investigation tried to replicate previous findings of a bilingual advantage. A bilingual advantage would have been demonstrated by smaller Stroop interference (i.e., smaller increases in response time for incongruent than for neutral trials) for bilinguals than for monolinguals. The results showed that bilingual young adults showed a general speed advantage relative to their monolingual counterparts, but this was not associated with smaller Stroop interference. Older adults showed no effect of bilingualism. Thus, the present investigation does not find evidence of a bilingual advantage in young or older adults and suggests limits to the robustness and/or specificity of previous findings.     

Age-related differences in interlingual priming: a behavioural and electrophysiological investigation

Reaction time (RT) and the N400 ERP component were measured to examine age-related differences in bilingual language processing. Although young bilinguals appear to access both languages simultaneously (i.e., non-selective access), little is known about language selection in older adults. The effect of language context on language selectivity was investigated using interlingual homographs (IH; i.e., words with identical orthography but distinct semantic features in two languages, e.g., coin meaning 'corner' in French and 'money' in English). Younger and older French/English bilinguals were presented with triplets of letter strings comprised of a language context cue, an IH, and a target word, in a lexical decision semantic priming task. RT and ERP results support non-selective language access in young adults; however, the older bilinguals used the language context cue to bias their reading of the IH. Results are discussed in terms of age-related changes in language processing and context use in bilinguals.     

Inhibition and exuberance in preschool classrooms: associations with peer social experiences and changes in cortisol across the preschool year

Associations between behavioral inhibition and activity of the hypothalamic-pituitary-adrenocortical (HPA) system, a stress-sensitive neuroendocrine system indexed by salivary cortisol, have varied widely across studies. In the current study, we examined the role of peer social experiences in moderating patterns of association between inhibition/risk-aversion and cortisol reactivity. As expected based on previous research, preschool children (N = 165, 78 boys, 87 girls, 3.0-5.0 years) had significantly different social experiences in their preschool classrooms depending on temperament. Highly inhibited/risk-averse children were less socially integrated, less dominant, and less involved in aggressive encounters than both average and highly exuberant/risk-seeking children, but they were no more likely to be peer rejected. Highly exuberant children were more dominant, exhibited anger more often, and had friendships characterized by higher conflict. Cortisol levels fell from fall to spring for average and highly exuberant children but not for highly inhibited children. Unexpectedly, for highly inhibited children, having friends and being more dominant and popular than other highly inhibited children was associated with increasing cortisol levels over the school year. In contrast, highly exuberant children who were less socially integrated than other highly exuberant children maintained higher cortisol levels. Results indicate that the types of social experiences that affect stress-responsive biological systems may differ markedly for highly inhibited and highly exuberant children.     

Single case research results as clinical outcomes

The movement toward evidence-based treatments, interventions, or practices pressures single case research (SCR) to use statistical summaries which have broad credibility. These summaries also need to be easily understood and useful in schools and clinics. To date the effect size families, “proportion of variance” (R², Eta²) and “standardized mean difference” (Cohen's d, Hedges' g) have little popularity in SCR. This paper demonstrates a set of alternative Clinical Outcome indices widely used in the field of medicine: Risk Difference, Relative Risk, Relative Risk Improvement, and Odds Ratio, which compare patients in treatment versus control conditions. Translated to SCR designs, the baseline phase becomes the control condition, the intervention phase becomes the treatment condition, and improvement is defined as non-overlapping data between phases. The positive attributes of Clinical Outcomes are demonstrated: (a) easily interpretable results, (b) close relationship with concept of non-overlapping data, (c) minimal data assumptions, (d) minimal statistical expertise required, (e) multiple contrasts possible for diagnostic understanding, (f) exact confidence intervals for results, and (g) close relationship to Pearson R effect size family.     

Understanding expert testimony on child sexual abuse denial after New Jersey v. J.L.G.: Ground truth,disclosure suspicion bias,and disclosure substantiation bias

The New Jersey Supreme Court held in New Jersey v. J.L.G. (2018) that experts can no longer explain to juries why sexually abused children might deny abuse. The court was influenced by expert testimony that “methodologically superior” studies find lower rates of denial. Examining the studies in detail, we argue that the expert testimony was flawed due to three problems with using child disclosure studies to estimate the likelihood that abused children are reluctant to disclose abuse: the ground truth problem, disclosure suspicion bias, and disclosure substantiation bias. Research identifying groups of children whose abuse can be proven without reliance on disclosure reveals that denial of sexual abuse is common among abused children.     

Matching and naming objects by shape or function: age and context effects in preschool children

Three experiments tested preschoolers' use of abstract principles to classify and label objects by shape or function. Three- and 4-year-olds were instructed to match objects by shape or function. Four-year-olds readily adopted either rule, but 3-year-olds followed only the shape rule. Without a rule, 4-year-olds tended to match by shape unless object function was shown during matching (Experiment 2). Three-year-olds' ability to use a function rule was tested in several conditions (re-presenting functions; reminders to "use the rule"; repeating rule on every trial). None induced consistent function matching (Experiment 3). Supplemental memory and verbal tasks showed that 3-year-olds have trouble using function as an abstract basis of comparison. Naming data, however, show that preschoolers are learning that object labels are based on function. The results show preschoolers' growing flexibility in adopting abstract generalization rules and growing knowledge of conventions for extending words.     

The Early Marital Roots of Conjugal Distress and Divorce

This article summarizes research that challenges conventional wisdom about the early roots of marital distress and divorce. We abstract results from a 13-year study that focused on the extent to which long-term marital satisfaction and stability could be forecast from newlywed and early marital data. We explore the usefulness of three models emergent distress, enduring dynamics, and disillusionment designed to explain why some marriages thrive and others fail. The dominant paradigm, the emergent-distress model, sees newlyweds as homogeneously blissful and posits that distress develops as disagreements and negativity escalate, ultimately leading some couples to divorce. The results we summarize run counter to this model and suggest instead that (a) newlyweds differ considerably in the intensity of both their romance and the negativity of their behavior toward one another and, for those who remain married, these early dynamics persist over time; and (b) for couples who divorce, romance seems to deteriorate differently depending on how long the marriage lasts. Soon after their wedding, "early exiters" seem to lose hope of improving an unpromising relationship; "delayed-action divorcers" begin marriage on a particularly high note, yet quickly show signs of disillusionment. These delayed-action divorcers reluctantly give up on the marriage long after the romance has faded.