Randomized controlled trial of an intervention to prevent adherence failure among HIV-infected patients initiating antiretroviral therapy.

OBJECTIVE: Compare the efficacy of a multicomponent social support intervention to standard-of-care counseling on medication adherence among HIV-infected patients initiating antiretroviral therapy. DESIGN: Randomized controlled trial. Generalized estimating equations tested for differences in the percentage of participants achieving 90% adherence. MAIN OUTCOME MEASURES: Pill-taking, electronically monitored over 6 consecutive months; plasma viral load (VL), assessed at 3 and 6 months following initiation of therapy. RESULTS: Of 226 participants who were randomized and began the trial, 87 (38%) were lost to the study by 6 months. The proportion of adherent participants declined steadily over time, with no time by group interaction. Sustained adherence was associated with increased odds of achieving an undetectable VL (OR=1.78; 95% CI=1.01, 3.13). In intention-to-treat analyses, a larger proportion of the intervention group than the control group was adherent (40.15% vs. 27.59%, p=.02) and achieved an undetectable VL p=.04). However, the majority of participants who remained on study experienced some reduction in VL (>or=1-log drop or undetectable), regardless of experimental condition. CONCLUSION: The multicomponent social support intervention significantly improved medication adherence over standard-of-care counseling; evidence for improved virologic outcomes was inconsistent. Early discontinuation of care and treatment may be a greater threat to the health of HIV patients than imperfect medication-taking.     

Mental imagery and dyslexia: a deficit in processing multipart visual objects?

Dyslexic and normal control subjects memorized simple line patterns inside a grid and subsequently judged whether an "X" would have fallen on the pattern had it been present in an empty grid. The patterns were letters and novel shapes. The grids were presented to the left visual field, to the right visual field, or in central vision. Dyslexic subjects had difficulty generating images of multipart patterns, but this deficit was limited to letters. The findings suggest that dyslexics may have selective difficulty integrating visual information stored in long-term memory.     

COVID-19, Sex,Addictions, Women's Health,Care of the Elderly,and Medical Education

Journal of Religion and Health -     

National Norms and Correlates of the PHQ-8 and GAD-7 in Parents of School-age Children

Anxiety and depressive disorders are global public health concerns, and research suggests that these disorders are common in parents and can adversely influence family functioning. However, little is known about normative levels of anxiety and depressive symptoms in parents of school-age children. The present study reports on generalized anxiety and depressive symptoms in 1570 parents and guardians of a nationally representative sample of children ages five to twelve years using two widely used and validated questionnaires: the eight-item variant of the Patient Health Questionnaire depression scale (PHQ-8) and the seven-item Generalized Anxiety Disorder scale (GAD-7). Moderate to severe levels of generalized anxiety symptoms were reported in 12.7% of the total sample and moderate to severe levels of depressive symptoms were reported in 14.1% of the sample; 17.7% of the sample reported moderate to severe levels of either generalized anxiety or depressive symptoms. This percentage was higher for females, younger parents and guardians, and parents and guardians reporting lower household incomes. These data, collected online in early 2018, may be useful for researchers and clinicians studying and treating anxiety and depression in parents. Further, these data provide a baseline for researchers currently studying the impact of changes related to the novel coronavirus (COVID-19) pandemic (e.g., school closures) on the mental health of parents of school-age children.

     

A review of research on chaplains and community-based clergy in the Journal of the American Medical Association, Lancet, and the New England Journal of Medicine: 1998-2000

Based on the content analysis of quantitative research appearing in three medical journals, the authors conclude that, despite the shared ideal of providing spiritual care to patients on the part of physicians and chaplains, there is little attention given in these journals demonstrating and promoting this shared perspective. Suggestions for future research that would focus on this common medicine/religion interface and concern are noted.     

The costs of changing the representation of action: response repetition and response-response compatibility in dual tasks

In 5 experiments, the authors investigated the costs associated with repeating the same or a similar response in a dual-task setting. Using a psychological refractory period paradigm, they obtained response-repetition costs when the cognitive representation of a specific response (i.e., the category-response mapping) changed (Experiment 1) but benefits when it did not change (Experiment 2). The analogous pattern of results was found for conceptually similar (i.e. compatible) responses. Response-response compatibility costs occurred when the cognitive representations of the compatible responses were different (Experiments 3A & 3B), but compatibility benefits occurred when they were the same (Experiment 4). The authors interpret the costs of repeating an identical or compatible response in terms of a general mechanism of action selection that involves coding the task-specific meaning of a response.     

Arguments for adjuncts

It is commonly assumed across the language sciences that some semantic participant information is lexically encoded in the representation of verbs and some is not. In this paper, we propose that semantic obligatoriness and verb class specificity are criteria which influence whether semantic information is lexically encoded. We present a comprehensive survey of the English verbal lexicon, a sentence continuation study, and an on-line sentence processing study which confirm that both factors play a role in the lexical encoding of participant information.     

The role of response selection for inhibition of task sets in task shifting

Response selection in task shifting was explored using a go/no-go methodology. The no-go signal occurred unpredictably with stimulus onset so that all trials required task preparation but only go trials required response selection. Experiment 1 showed that shift costs were absent after no-go trials, indicating that response processes are crucial for shift costs. In Experiment 2, backward inhibition was absent after no-go trials. Experiments 3 and 4 demonstrated that response selection, rather than execution, causes backward inhibition. All 4 experiments showed effects of preparation time in go trials, suggesting that advance preparation must have also occurred in no-go trials. The authors concluded that inhibition of irrelevant task sets arises only at response selection and that residual shift costs reflect such persisting inhibition.     

Inductive reasoning and judgment interference: experiments on Simpson's paradox

In a series of experiments on inductive reasoning, participants assessed the relationship between gender, success, and a covariate in a situation akin to Simpson's paradox: Although women were less successful then men according to overall statistics, they actually fared better then men at either of two universities. Understanding trivariate relationships of this kind requires cognitive routines similar to analysis of covariance. Across the first five experiments, however, participants generalized the disadvantage of women at the aggregate level to judgments referring to the different levels of the covariate, even when motivation was high and appropriate mental models were activated. The remaining three experiments demonstrated that Simpson's paradox could be mastered when the salience of the covariate was increased and when the salience of gender was decreased by the inclusion of temporal cues that disambiguate the causal status of the covariate.     

The role of temporal unpredictability for process interference and code overlap in perception-action dual tasks

Two experiments explore interference in dual tasks. The first task required perceptual judgment of the movement direction (left vs right) of a briefly presented stimulus; the second task was a tone-discrimination reaction-time (RT) task. Participants reported their judgment at leisure. In 50% of the trials they were told to ignore the stimulus (no report). The directions of stimulus movement and response in the RT task could either be the same or different, establishing cross-task compatibility (CTC) relations. We varied the degree of temporal unpredictability by using two stimulus-onset asynchronies (SOA, 100 ms vs 1200 ms) for the task stimuli. In Experiment 1, SOA was varied randomly within blocks of trials in one group and between blocks in another group. In Experiment 2, only the short SOA was used in one group and only the long SOA in another group. In both experiments, we observed substantially longer RTs with the short compared with the long SOA, regardless of whether there was temporal certainty (blocked or constant SOA) or uncertainty (random SOA) about stimulus onset. We assume that the process of encoding into short-term memory in one task interferes with concurrent retrieval processes (i.e., response selection) in the other task. This process interference effect was strongly reduced in no-report trials. Furthermore, we found shorter RT in compatible than in incompatible trials. This CTC effect diminished with long SOA but occurred even in no-report trials, implying that it refers to an automatically activated and then decaying code that primes response selection in the RT task.