Effects of Acute Stress or Centrally Injected Interleukin-1beta on Neuropeptide Expression in the Immune System

Acute stress stimulates the expression and release of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) from the hypothalamus, and the pro-opiomelanocortin products beta-endorphin and ACTH from the anterior pituitary. These neuropeptides are also expressed in immune tissues, and it has been proposed that they may modulate immune responses to stress through paracrine mechanisms. We subjected rats to restraint stress or central injection of interleukin (IL)-1beta to determine whether these acute stimuli can alter the expression of neuropeptides in the spleen and thymus. Restraint stress significantly increased the contents of all these neuropeptides in thymic, but not splenic, extracts. A single icv injection of IL-1beta increased contents of CRH, AVP, ACTH and beta-endorphin in the spleens of both sham-operated and adrenalectomised (ADX) rats. IL-1beta increased thymic contents of CRH and ACTH in sham-operated rats but these increases were not observed in ADX rats. These results suggest that the effects of IL-1beta on neuropeptide expression in the spleen are independent of glucocorticoids, whereas IL-1beta stimulation of neuropeptide expression in the thymus is dependent on circulating glucocorticoids. There were significant correlations between increases in CRH, ACTH and beta-endorphin in the spleen, and between CRH and ACTH in the thymus, consistent with the suggestion that IL-1beta-induced increases in ACTH and beta-endorphin may be mediated through CRH. These results provide evidence that stressors can directly influence neuropeptide expression in immune tissues. Thus stress may influence immune functions through paracrine mechanisms involving locally synthesised neuropeptides as well as through activation of the hypothalamo-pituitary-adrenal axis.     

Development of a Cognitive-Behavioral Intervention Program to Treat Anxiety and Social Deficits in Teens with High-Functioning Autism

Anxiety is a common co-occurring problem among young people with autism spectrum disorders (ASD). Characterized by deficits in social interaction, communication problems, and stereotyped behavior and restricted interests, this group of disorders is more prevalent than previously realized. When present, anxiety may compound the social deficits of young people with ASD. Given the additional disability and common co-occurrence of anxiety in ASD, we developed a manual-based cognitive-behavioral treatment program to target anxiety symptoms as well as social skill deficits in adolescents with ASD [Multimodal Anxiety and Social Skills Intervention: MASSI]. In this paper, we describe the foundation, content, and development of MASSI. We also summarize data on treatment feasibility based on a pilot study that implemented the intervention.     

Maintaining global coherence in reading: The role of sentence boundaries

In four experiments, we examined the reinstatement of backgrounded information in locally coherent passages, investigating the influence of syntactic boundaries, such as periods, on the time course of this process. In Experiment 1, using a line-by-line reading paradigm, readers were delayed in noticing a contradiction on a target line when the sentence continued onto a posttarget line. Consistent with this, in Experiments 2A and 2B, the results of a recognition probe demonstrated that relevant concepts from long-term memory were not integrated immediately unless the contradiction was followed by a period. Experiment 3 demonstrated that sentence boundaries are sufficient to facilitate the integration of related background information but are not necessary; additional time served the same purpose. Consistent with a memory-based text-processing framework, it appears that the reactivation of related information is initiated automatically but that an integration stage is influenced by such factors as syntactic boundaries.     

Attributing social and physical meaning to ambiguous visual displays in individuals with higher-functioning autism spectrum disorders

The weak central coherence (WCC) account of autism characterizes the learning style of individuals with this condition as favoring localized and fragmented (to the detriment of global and integrative) processing of information. This pattern of learning is thought to lead to deficits in aspects of perception (e.g., face processing), cognition, and communication (e.g., focus on disjointed details rather than "gist" or context), ultimately leading to social impairments. This study was carried out to examine whether WCC applies to social and to non-social aspects of learning alike, or, alternatively, some areas of learning (e.g., physical reasoning) are spared in autism. classic social animation as quantified in the Social Attribution Task (SAT) () and a novel animation involving physical reasoning (the Physical Attribution Task; PAT) were used to test the domain specificity of the WCC hypothesis. A pilot study involving a reference group of typically developing young adults and a group of individuals with higher-functioning autism spectrum disorders (ASDs) revealed gender differences in the reference group in regards to performance on the PAT (males outperformed females). In a follow-up case-control comparison involving only males where the ASD group was matched on age and IQ to a typically developing (TD) group of children, adolescents, and adults, the ASD group showed lower SAT scores and comparable PAT scores relative to the TD group. The interaction of diagnostic group by task was highly significant, with little overlap between the groups in the distributions of SAT minus PAT scores. These results indicated preserved integrative skills in the area of physical attribution in the ASD group, thus failing to support the WCC account as a domain-independent (or more general) model of learning in autism, while highlighting the centrality of the social deficits in the characterization of learning style in the autism spectrum disorders.     

Altered face scanning and impaired recognition of biological motion in a 15-month-old infant with autism

Mounting clinical evidence suggests that abnormalities of social engagement in children with autism are present even during infancy. However, direct experimental documentation of these abnormalities is still limited. In this case report of a 15-month-old infant with autism, we measured visual fixation patterns to both naturalistic and ambiguous social stimuli: video scenes of a caregiver and point-light animations of human action. Results suggested that viewing patterns of the child with autism were driven by the physical contingencies of the stimuli rather than by their social context. If corroborated in larger studies, this observation would advance the hypothesis that mechanisms of social development which rely on preferential engagement with socially contingent conspecifics - and which emerge in the very first weeks of life in typical infants - are developmentally derailed in children with autism.     

Hypothalamo-Pituitary-Adrenocortical Regulation Following Lesions of the Central Nucleus of the Amygdala

Previous reports indicate that the central nucleus of the amygdala (CeA) stimulates adrenocorticotropin and corticosterone secretion, suggesting a role for this region in central hypothalamo-pituitary-adrenocortical (HPA) stress regulation. To evaluate this hypothesis, this study assessed the impact of CeA lesion on the response of hypophysiotrophic paraventricular nucleus (PVN) neurons to acute restraint and chronic unpredictable stress exposure. In contrast to previous reports, CeA lesions did not affect corticosterone or ACTH secretion induced by acute stress. Acute restraint increased PVN corticotropin releasing hormone (CRH) mRNA expression, increased the number of parvocellular PVN neurons expressing the co-secretagogue arginine vasopressin (AVP), and induced cFOS mRNA expression in the parvocellular PVN. However, there was no additional effect of CeA lesion on any measure of PVN activation. Chronic unpredictable stress exposure induced long-term activation of the HPA axis, noted by thymic involution, adrenal hypertrophy and increased PVN CRH mRNA expression. Stress-induced changes in thymus and adrenal weights were not affected by CeA lesion. Further, CeA lesion rats did not differ from controls in post-stress CRH mRNA expression. However, basal CRH mRNA expression was increased in the PVN of CeA rats, suggesting that the CeA plays a role in long-term inhibition of the PVN. The results of these studies are not consistent with the hypothesis that the CeA is necessary for stress-induced pituitary-adrenocortical activation. Rather, this region may play a stressor-specific modulatory role in regulation of HPA function.     

Repeating phrases across unrelated narratives: Evidence of text repetition effects

Research has shown that text repetition effects are limited to conditions in which the context remains consistent across the two processing episodes, particularly when readers are focused on comprehension. Despite this, we found evidence of transfer effects across unrelated narratives. In a repeated condition, an ambiguous phrase appeared in two consecutive stories. In Story A, the phrase was presented in a sarcasm-biasing context, and in Story B, the phrase was presented in a neutral context. The pattern of findings from an offline measure (Experiment 1) and a reading time measure (Experiments 2, 3, and 4) indicated that participants were more likely to interpret the phrase in Story B as sarcastic in the repeated version than in a nonrepeated version, in which the phrase was absent from Story A. We conclude that during the reading of Story B, the phrase was reactivated from memory, even though the two stories were unrelated.     

Seeing what they read and hearing what they say: Readers’ representation of the story characters’ world

Do readers “see” the words that story characters read and “hear” the words that they hear? Just as priming effects are reduced when stimuli are presented cross-modally on two different occasions, we found reduced transfer effects when story characters were described as experiencing stimuli cross-modally. In Experiment 1, a repeated phrase was described as being part of a spoken message in both Story A and Story B, and transfer effects were found. In Experiment 2, in contrast, when the phrase was described as a written note in one story and a spoken message in the other, reading-time results indicated that readers did not retrieve the meaning of the repeated phrase. The results are consistent with findings indicating that visual imagery simulates visual processing and that auditory imagery simulates auditory processing. We conclude that readers mentally simulate the perceptual details involved in story characters’ linguistic exchanges.     

“Tell Me Who Your Enemies Are”: Government Reports About the “Cult” Phenomenon in Israel

Between 1982 and 2011, four Israeli governmental reports addressing ostensible dangers from “cults” (new religious movements, or NRMs) were issued. The 1980s reports use a collectivist discourse, in which the state sees itself as defending the collective's borders from external threats and representing various sectors while seeking consensual values. The 1990s report marks an interim stage in which the state tries to balance individual liberties with sectoral interests. The 2011 report focuses solely on harm to individuals and is the harshest of the four. The reports reflect milestones in three processes of change that have taken place in Israeli society: from a collectivist‐hegemonic ethos to a multisectoral one; from a focus upon society to a focus on the individual; and from nationalistic values to universalistic ones. At every point in time, NRMs represented a different perceived threat to Israeli society. We explain how multisectoralism brings about both tolerance toward new religious phenomena and fierce anti‐cultic activity.