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Bilateral electrolytic lesions in the pedunculopontine nucleus (PPN) impair acquisition of short-term, or concurrent, Taste Aversion Learning (TAL) in rats. This type of TAL is characterized by the daily presentation of two different flavor stimuli at the same time, one associated with simultaneous intragastric administration of an aversive product (hypertonic NaCl) and the other with physiological saline. Sham-lesioned control animals learn this taste discrimination task, but both lesioned animals and control animals learn a long-term, or delayed, TAL task in which each gustatory stimulus is presented individually every other day and the intragastric products, LiCl (0.15 M) and physiological saline, are administered after a 15-min delay. These results are analyzed in the context of the cerebellar circuits involved in learning and in relation to the two TAL modalities described above. 相似文献
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Justo L 《The American journal of bioethics : AJOB》2005,5(1):56-8; author reply W15-8
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Taste aversion learning (TAL) is a type of learning characterized by rejection of a gustatory/flavor stimulus as a consequence of its pairing with visceral discomfort and malaise. TAL can be established in the laboratory by two different behavioral procedures, concurrent or sequential. Neural mechanisms of these learning modalities remain to be elucidated, but several studies have discussed the implication of various anatomical structures, including the vagus nerve. The aim of this study was to examine the role of capsaicin-sensitive vagal afferent fibers in concurrent (Experiment 1) and sequential (Experiment 2) TAL in Wistar rats. Results showed that perivagal administration of capsaicin (1mg of capsaicin dissolved in 1ml of vehicle (10% Tween 80 in oil)) blocked acquisition of concurrent but not sequential TAL. These data support the hypothesis of two different modalities of TAL mediated by distinct neurobiological systems, with vagal nerve participation only being essential in concurrent TAL. 相似文献
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This study investigated cardiovascular reactivity of hypertensive adults during periods of emotional stress. Two types of instructions were given at different moments, to the same subject, either to express or to suppress feelings during role-play. Expressing, but not inhibiting, emotions elicited significantly higher reactivity during responding to negative scenes, followed by responding during the positive interactions. Blood pressure increases in both expressing and inhibiting conditions, were also found during the instruction periods. Results indicated that socially demanding situations represent a stressor whose effects may vary depending on whether or not respondents regulate expression of emotions. It is suggested that the difficulty in expressing emotions found in some hypertensive individuals may have the function of controlling or reducing blood pressure reactivity. 相似文献
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Simon MJ Garcia R Zafra MA Molina F Puerto A 《Neurobiology of learning and memory》2007,87(3):332-342
Electrical stimulation of the External Lateral Parabrachial Subnucleus (LPBe), a food-related area, induced behavioral preferences for associated stimuli in a taste discrimination learning task. Although this stimulation appeared to be ineffective to elicit standard lever press self-stimulation, it induced place preference for one of two training compartments of a rectangular maze in which animals (adult male Wistar rats) received concurrent electrical brain stimulation. In subjects that consistently showed a preference behavior in different trials, administration of the opioid antagonist naloxone (4 mg/ml/kg) blocked concurrent learning when the test was made in a new maze but not in the same maze in which animals had learned the task. These results are discussed in terms of the possible participation of the LPBe subnucleus in different natural and artificial brain reward systems. 相似文献
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Gómez-Tatay Lucía Hernández-Andreu José Miguel Aznar Justo 《Science and engineering ethics》2019,25(1):97-111
Science and Engineering Ethics - Synthetic biology opens up the possibility of producing new entities not found in nature, whose classification as organisms or machines has been debated. In this... 相似文献
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Taste aversion learning can be established according to two different procedures, concurrent and sequential. For the concurrent task, two different taste stimuli are offered at the same time, one associated with simultaneous intragastric administration of an aversive stimulus and the other associated with physiological saline. This discrimination is learned by sham-lesioned control animals and by animals with lesions in the cerebellar cortex but not by rats lesioned in the inferior olive. At the same time, animals with lesions in the inferior olive and sham-lesioned animals achieve sequential learning when the gustatory stimuli are offered individually during each daily session. The results obtained show that electrolytic lesions in the inferior olive impair acquisition of concurrent learning and are analyzed in terms of an anatomical system consisting of the vagus nerve, inferior olive, and cerebellum, which differentiates between the two modalities of taste aversion learning, concurrent and sequential. 相似文献
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Dianne Bertolino-Green Ph.D. Glenn H. Asquith Jr. Ph.D. J. L. Cedarleaf J. Earl Thompson Jr. Sarah F. Speed Rodney J. Hunter Rush Otey Herbert Anderson Rev. James G. Emerson Ph.D. Charles B. Cousar Ph.D. Justo L. González Louis R. Lothman S.T.D. J. Harold Ellens Christie Cozad Neuger Ph.D. C. Benton Kline Jasper N. Keith Jr. Bobbie Wrenn Banks M. Div. John Patton Elizabeth Liebert Jeanne Stevenson Moessner Thomas H. Phillips M.Div. Marie McCarthy Ph.D. Paul J. Johnson III Leslie E. Cole Shirley C. Guthrie 《Pastoral Psychology》1991,39(6):373-431
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Amparo M. Mrmol Justo Puerto Francisco R. Fernndez 《Journal of Multi-Criteria Decision Analysis》1998,7(6):322-329
This paper addresses multicriteria decision problems in which only partial information is given in the decision-making process. We generalize existing results about preference relations induced by nonnegative inverse matrices, allowing linear relations on weights with upper and lower bounds. In addition we develop conditions for additional information that preserve the special properties studied and show how to incorporate the new information to the model. © 1998 John Wiley & Sons, Ltd. 相似文献