排序方式: 共有29条查询结果,搜索用时 15 毫秒
1.
Contextual fear conditioning under training conditions involving high stressor intensities has been proposed as an animal model for traumatic memories. The strength of memory for this task has been related to the intensity of the conditioning stressor and post-training corticosterone values. However, administration of a glucocorticoid receptor (GR) antagonist only attenuated memory for this task in rats conditioned at a moderate shock intensity (0.4 mA), but failed to influence conditioning in rats trained at a high shock intensity (1 mA). Here, we further questioned whether interfering with glucocorticoid action at the time of training might be effective in influencing contextual fear conditioning in rats trained under different shock intensities. Rats were subcutaneously injected with the glucocorticoid synthesis inhibitor metyrapone (50, 100 mg/kg) 90 min before being trained in the contextual fear conditioning task, at either 0.4 or 1 mA shock intensities. The results showed that metyrapone, in a dose-dependent manner: (i) attenuated long-term expression of contextual fear conditioning, both in 0.4- and 1 mA-trained rats; and (ii) efficiently prevented increased plasma corticosterone concentration. In addition to further supporting a facilitating role of glucocorticoids in memory consolidation, these findings suggest a critical involvement of these hormones in the formation of traumatic memories. 相似文献
2.
3.
Joy R. Pemberton Joaquin Borrego Jr. Simone Sherman 《Journal of psychopathology and behavioral assessment》2013,35(1):35-44
Although many interventions address children’s externalizing behavior problems, negative treatment outcomes remain common. Reasons for success or failure are frequently unclear, due in part to a lack of research identifying treatment change mechanisms. The current study evaluated differential attention as a mechanism of change in Parent–Child Interaction Therapy (PCIT), a treatment for children with externalizing problems. Using sequential coding and time-series analysis, we examined parent–child interactions across treatment for three families. Contrary to hypotheses, child prosocial behaviors and parent skill use held steady or decreased across coaching periods, with the exception of one family, where the parent’s skill use increased during coaching. Partial support was found for the hypothesis that parent differential attention would predict child prosocial behavior in the next minute. These results provide support for differential attention as a mechanism of change, but also demonstrate that this factor is not the only such mechanism. 相似文献
4.
The social intelligence hypothesis proposes that the challenges of complex social life bolster the evolution of intelligence, and accordingly, advanced cognition has convergently evolved in several social lineages. Lions (Panthera leo) offer an ideal model system for cognitive research in a highly social species with an egalitarian social structure. We investigated cognition in lions using a novel resource task: the suspended puzzle box. The task required lions (n = 12) to solve a novel problem, learn the techniques used to solve the problem, and remember techniques for use in future trials. The majority of lions demonstrated novel problem-solving and learning; lions (11/12) solved the task, repeated success in multiple trials, and significantly reduced the latency to success across trials. Lions also demonstrated cognitive abilities associated with memory and solved the task after up to a 7-month testing interval. We also observed limited evidence for social facilitation of the task solution. Four of five initially unsuccessful lions achieved success after being partnered with a successful lion. Overall, our results support the presence of cognition associated with novel problem-solving, learning, and memory in lions. To date, our study is only the second experimental investigation of cognition in lions and further supports expanding cognitive research to lions. 相似文献
5.
6.
7.
Joaquin Trujillo 《Human Studies》2007,30(4):345-356
This is an existential-phenomenological reading of Max Weber’s “Class, Status, Party” that seeks a fuller understanding of meaning accomplishment in a stratified World. I appropriate stratification as a single meaning structure ontically defined by domination, intersubjectivity, and life-chances and ontologically determined by the power-to-be (Seinkönnen), There-being-with-others (Mitdasein), and potentiality (Möglichkeit). I then discuss the significance of these structures in finite transcendence (There-being, Dasein) and describe ways they factually unfold in World achievement. I conclude with logotherapeutic reflections concerning meaning accomplishment in a stratified World and a summary of key questions facing existential-phenomenology in light of the likelihood that There-being must embrace, indeed, live, the inherent equality of Being (Gleichheit des Seins) among Daseins to accomplish its authenticity. 相似文献
8.
The ways in which children appraise and cope with school bullying are likely to influence the long-term outcomes experienced. To examine this possibility, 219 Spanish undergraduate students (73 male, 146 female) aged between 18 and 40, completed an adapted version of the Retrospective Bullying Questionnaire (RBQ; Sch?fer et al., 2004) and a distress scale (Rivers, 1999). Results indicated that neither coping strategies reported by victims of bullying nor the match between control appraisal and coping strategy influenced levels of distress experienced as adults. Control, threat and challenge appraisals did, however, influence long-term distress. Explanations for these effects are discussed, and include the possibility that appraisals may directly influence levels of distress and the quality of emotions experienced by victims during the actual bullying episode. Active strategies were perceived by students to be effective in dealing with bullying, whereas those centered on avoiding the conflict, or which involved aggression, were considered ineffective. 相似文献
9.
Animal Cognition - Cooperative interactions vary in complexity. The emotional reactivity hypothesis posits that cooperative complexity is constrained by social intolerance. Relaxed social... 相似文献
10.
Lado-Abeal J Clapper JA Chen Zhu B Hough CM Syapin PJ Norman RL 《Stress (Amsterdam, Netherlands)》2002,5(2):113-119
The first objective of this study was to determine whether insulin-induced hypoglycemia (IIH) inhibits LH secretion in unrestrained female macaques during the follicular phase of the menstrual cycle. There was a consistent inhibitory effect of hypoglycemia on LH secretion within 3 h in these females. This inhibition was likely an indirect effect since low glucose levels did not inhibit GnRH secretion from GT1-1 neurones in vitro. We next investigated whether administration of a vasopressin antagonist (AVPa) either alone, or with naloxone could reverse the IIH-induced inhibition of LH release. Females were studied in the follicular phase during 10 h periods with blood samples collected every 10 min. Experimental groups were IIH (n=6), IIH+AVPa (n=5) and IIH+AVPa+naloxone (n=4). The first 5 h of each study served as a control and hypoglycemia was then induced with insulin. The AVPa was given as a bolus (180 microg) just before the insulin and was followed by a continuous infusion (180 microg/h) for 5 h. Naloxone (5 mg/kg) was given with the AVPa and followed by a continuous infusion (5 mg/kg/h) for 5 h. In the IIH group, LH reached its lowest value 3-4 h after insulin. Neither AVPa nor AVPa+naloxone infusion reversed the inhibitory action of hypoglycemia on LH release. These data suggest that if there are inhibitory actions of vasopressin and endogenous opioids on GnRH release induced by hypoglycemia, they are not sufficient to explain the suppression of GnRH/LH release in intact female primates. 相似文献