Psychological Well-Being and the Metabolic Syndrome in African and Caucasian Women in South Africa

This study explored the association between comprehensive psychological well-being and the metabolic syndrome (MS), as well as whether women without MS markers differ significantly from women with MS (three or more markers) on specific facets of psychological well-being. African (N=102) and Caucasian (N=115) women completed self-report questionnaires on psychological well-being, and biological markers for MS were determined. Results indicated a significant association between comprehensive psychological well-being and the MS in Caucasian women, but not in the case of African women. Caucasian women without MS had higher levels of perceived support from friends and family, environmental mastery, purpose in life, sense of coherence, affect balance and positive relationships than those with MS. African women without MS had higher levels of positive relationships and an optimistic explanatory style, but lower levels of perceived support from family. Further research is indicated.     

THE ETHICS OF LAND RESTITUTION

Many indigenous communities were dispossessed of their land during the period of colonial rule. This long process resulted in forced demographic removals and perennial poverty. Nowadays these communities, especially Third World groups, seek redress of this situation through legal processes of land restitution. This process is met by resistance from landowners in these countries, the colonial powers of old, as well as from big corporations that benefited from the dispossession. The investigation undertaken in this article addresses the ethics of land reform from a Christian ethical perspective. The policy of land restitution in South Africa is used as a case study, but the results of this research are also applicable to other parts of the world where land restitution is considered. The article first evaluates the biblical teachings of land and land reform and their implications for modern ethics. In the light of these issues, the article addresses the question of whether land ownership can be considered as a fundamental human right. The article also focuses on the legality of expropriation and dispossession of land for the purposes of restitution. Moreover, guidelines for fair and legal restitution within the context of Christian ethics and legal philosophical principles are proposed.     

Mothers' speech in three social classes

Functional and linguistic aspects of the speech of Dutch-speaking mothers from three social classes to their 2-year-old children were studied. Mothers' speech in Dutch showed the same characteristics of simplicity and redundancy found in other languages. In a free play situation, both academic and lower middle class mothers produced more expansions and used fewer imperatives, more substantive deixis, and fewer modal verbs than working-class mothers. These differences were not present while mothers were reading books with their children. In general, the mothers' speech was more complex in the book reading situation than during free play.     

Predictive Genetic Testing in Children: Constitutional Mismatch Repair Deficiency Cancer Predisposing Syndrome

Biallelic germline mutations in mismatch repair genes predispose to constitutional mismatch repair deficiency syndrome (CMMR-D). The condition is characterized by a broad spectrum of early-onset tumors, including hematological, brain and bowel and is frequently associated with features of Neurofibromatosis type 1. Few definitive screening recommendations have been suggested and no published reports have described predictive testing. We report on the first case of predictive testing for CMMR-D following the identification of two non-consanguineous parents, with the same heterozygous mutation in MLH1: c.1528C > T. The genetic counseling offered to the family, for their two at-risk daughters, is discussed with a focus on the ethical considerations of testing children for known cancer-causing variants. The challenges that are encountered when reporting on heterozygosity in a child younger than 18 years (disclosure of carrier status and risk for Lynch syndrome), when discovered during testing for homozygosity, are addressed. In addition, the identification of CMMR-D in a three year old, and the recommended clinical surveillance that was proposed for this individual is discussed. Despite predictive testing and presymptomatic screening, the sudden death of the child with CMMR-D syndrome occurred 6 months after her last surveillance MRI. This report further highlights the difficulty of developing guidelines, as a result of the rarity of cases and diversity of presentation.