Dkk-1蛋白的研究现状、进展及临床意义

Dkk(Dickkopf)是Wnt信号通路中重要的拮抗因子之一,通过与Wnt受体复合体LRP5/6结合来抑制Wnt信号通路.Dkk-1在代谢性骨病(骨质疏松症Paget病)、多种癌症、骨关节炎等疾病中都存在着异常表达并起到重要作用.本文将对现有的Dkk-1基因的研究进展进行总结,并对Dkk-1基因的研究意义进行了展望.     

编码后奖赏影响基于议程的学习：奖赏预期和结果的作用

基于ABR模型考察奖赏预期和奖赏结果对不同难度词对记忆与元记忆的影响。结果发现：(1)限时学习条件下,奖赏结果促进不同难度词对记忆成绩和学习判断,奖赏预期仅提高简单词对的记忆成绩。(2)自定步调学习条件下,定时学习判断时奖赏结果仅影响学习判断;奖赏预期促进高难度词对的学习时间分配,从而提高记忆成绩和学习判断。(3)在自定步调学习时,奖赏预期超越难度成为影响学习时间分配的因素。以上结果表明,个体会综合奖赏预期、奖赏结果和难度构建学习议程,足够大的奖赏预期会超越难度成为议程构建的主导因素。但奖赏预期和奖赏结果对记忆成绩、学习时间分配和学习判断的影响受学习条件调节。     

Asserting your mind: Interruptions extremize consumer choices

Interruptions prevail in the retail environment, especially during consumer decision-making. However, scant research has examined whether and how interruptions that suspend decisions affect consumer choices. We posit that interruptions heighten the consumers' preference certainty, which leads to a choice extremity effect—consumers choose their preferred products even more and their unpreferred products even less. Six experiments provide convergent evidence for the choice extremity effect and the underlying process. Study 1a shows that interruptions lead to choice extremity with a vice product (i.e., chips). Study 1b confirms the effect in the context of incentive-compatible choices. Study 2 replicates the choice extremity effect with a virtue product (i.e., yogurts). Study 3 further tests the robustness of the effect with a decision-related interruption. Study 4 shows that preference certainty mediates the effect of interruptions on choice extremity and rules out the level of arousal and task involvement as alternative accounts. Using a moderation approach, Study 5 shows that the choice extremity effect disappears when consumers have high self-concept clarity. The present study contributes to research on interruptions, preference certainty, and consumer choices and provides implications for marketers.     

Insights into computational thinking from think-aloud interviews: A systematic review

This systematic review examines 35 empirical studies featuring the use of think-aloud interviews in computational thinking (CT) research. Findings show that think-aloud interviews (1) are typically conducted in Computer Science classrooms and with K-12 students; (2) are usually combined with other exploratory CT assessment tools; (3) have the potential to benefit learners with special needs and identify the competency gaps through involving diverse participants; (4) are conducted in the absence of cognitive models and standard procedures; and (5) display insufficient definitional and methodological rigor. Theoretically, this review presents a systematic assessment about the application of think-aloud interviews in CT studies and identifies the limitations in existing CT-related think-aloud studies. Practically, this review serves as a reference for studying the cognitive processes during CT problem-solving and provides suggestions for CT researchers who intend to incorporate think-aloud interviews in their studies.     

自由回忆和线索回忆测验中的系列位置效应

本文以96个中国汉字为材料,使用自由回忆和线索回忆测验方法,对20名被试进行6组分测验和最后所有汉字的总测验。发现自由回忆分测验中存在明显的系列位置效应,总测验出现负近因现象;线索回忆分测验也表现出明显的系列位置效应,但最后的总测验没有出现负近因现象。上述结果验证了Bjork和Whitten（1974）提出的顺序或情景理论。     

传统统计方法面临的挑战:元分析方法

利用计算机构造实验组和控制组总体,进行传统统计方法与元分析比较实验研究。在实验组总体高出控制组总体０．５０个标准差的提下,传统ｔ检验的统计检验能力（Ｐ）仅为为４１％;而利用元分析的方法进行统计分析,其结果与计算机构造模型有很高的一致性从而提出元分析方法在进入心理学实验研究和证实理论方面的有效性和可靠性,以及传统统计方法面临挑战的事实。     

Cultural orientation and psychological well-being in Chinese Americans

Examined cultural orientation in the domains of language proficiency, cultural activity, and social relationship, and its relationship with psychological well-being in a group of 143 Chinese Americans in San Francisco. Four indicators of psychological well-being were utilized, two assessing the experience of distress (depression level and negative affect) and two assessing positive well-being (positive affect and life satisfaction). Domain-specific cultural orientations were found to hold differential relationships with psychological well-being. For instance, bicultural activity orientation predicted the best psychological well-being (regardless as to how it was assessed), but socially separatist individuals experienced less negative affect than assimilated and bicultural respondents. Findings were discussed in the context of the multicultural setting of San Francisco. It is suggested that future research retain separate assessments of domain-specific cultural orientation, examine the contribution of the community's ethnic/cultural composition to its members' cultural orientations (i.e., address the role of person-environment fit) and study their impact on psychological well-being. The data reported here were collected as part of the author's doctoral dissertation. Ricardo F. Munoz and Guillermo Bernal guided and supported the implementation of this study; Sunwoo Lee assisted with the data analysis; and Edison J. Trickett and the anonymous reviewers offered helpful suggestions.     

关联性记忆错觉的产生与保持

两项实验对关联性记忆错觉的产生与保持进行了考察。实验结果表明,关联性记忆错觉接近学过词的回忆水平,但它的产生不随年龄的变化而变化;时间变量对关联性记忆错觉的影响不显著。此外,关联性记忆错觉不同于学过的词,在延迟加快时没有系列位置效应的产生。     

关键词方法与英语词汇的掌握

本实验用中国学生对国外的学习外语词汇的关键词方法进行了验证。结果表明现有的关键词方法不适于中国学生,但改进了的新关键词方法明显地有利于学生均英译中。     

死亡凸显对自我姓名注意瞬脱对抗效应的影响

已有研究表明死亡凸显会抑制自我面孔和自我参照记忆加工的自我优势,可是死亡凸显对自我姓名的影响尚不明确,本研究采用事件相关电位技术,探索死亡凸显对自我姓名注意瞬脱对抗效应及其大脑神经活动的影响。58名被试在经历不同的启动任务后,完成自我姓名、朋友姓名和名人姓名的注意瞬脱任务。行为结果发现自我姓名识别正确率显著高于朋友姓名和名人姓名,表现出稳定的自我姓名加工的注意瞬脱对抗效应;电生理数据发现死亡启动后自我姓名诱发的P300波幅显著低于消极启动组和中性启动组,而朋友姓名和名人姓名并不受启动的影响。本研究结果与以往研究结果共同表明死亡想法凸显会使个体将抑制自我加工（自我姓名、自我面孔和自我参照记忆）作为应对远端死亡焦虑的一种手段。