Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Family planning of Portuguese immigrants and integration in Belgium

A substantial immigration of Portuguese and other foreign nationals to Belgium due to a favorable immigration policy guides this investigation to focus on this group in order to study the influence of the acculturation experience on birth-control practices. Choosing a sample of 100 married women within a group of 998 Portuguese immigrants in an urban municipality in Brussels, the study sets out specifically to investigate whether these immigrants adopt attitude patterns of the receiving social group or if they preserve the customs of their original community. The hypothesis held by the study was that the better the woman's integration into Belgian society, the larger her knowledge and acceptance of contraceptives would be. The study found that the majority of interviewed immigrants remained poorly integrated into the Belgian society, and that the transition from a traditional to an industrial society had not included great changes in attitudinal behavior which would facilitate social and cultural integration into the new society. In terms of attitudes toward contraception, negative behavior was observed to be linked not to levels of acculturation, but rather to lack of information. Though the majority of respondents expressed desires for controlled fecundity even when still in Portugal, those who came to Belgium with no previous knowledge or desires admitted to having felt the need for contraceptive practice. The crucial factor in acceptance of modern contraceptive practices is singled out as one of communication. Access to information about contraception is readily available in the Belgian society. The information actually obtained by the women, however, depended on their access to informational channels, the circumstances through which they got in touch with such sources, and their problems with a language barrier when relying on the media through which contraceptive knowledge was made available.     

Superego transformations through the analyst's capacity for reverie

The author discusses the application of certain Kleinian and Bionian principles to psychoanalytic work with patients who suffer from symptoms arising out of pathological superego functioning. Clinical vignettes are presented to demonstrate how the analyst's willingness to employ reverie, and to move from conviction-based interpretations to more open and tentative ones, can help such patients to change maladaptive behavioral patterns that may have stemmed from early interactions with an unavailable or nonreceptive Other.     

Is the unilateral lesion of the left substantia nigra pars compacta sufficient to induce working memory impairment in rats?

Adult male Wistar rats with a substantia nigra pars compacta (SNc) lesion induced by intranigral administration of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used as a model of early phase Parkinson's disease (PD). This lesion caused a partial depletion of striatal dopamine (DA). The animals were submitted to a spatial working memory version of the water maze task in which they had to find a hidden (submersed) platform using online-maintained information that the platform remains in the same place during four consecutive trials, but that it is moved to another place every training day. Left, but not right SNc-lesioned rats were impaired in finding the platform in the second trial. This result suggests that the left SNc plays a key role in spatial working memory. Control experiments ruled out the possibility that motor impairment, sensory neglect, and/or impairment in the mental representation of the contralateral spatial environment had affected performance of the SNc-lesioned rats.     

SOME IMPLICATIONS OF BION'S THOUGHT

Following up Bion's idea that dreaming is a continuous process that takes place in waking life as well as in sleep, the author develops its theoretical and technical implications. He describes the narrative derivatives of waking dream thought as the means, or interface, whereby access may be had, albeit indirectly, to the constantly forming sequences of alpha-elements. Examples of the formation of these sequences out of childhood memories, present-day experiences and sexual feelings are given. Reference is also made to the notion of the analytic field. The author goes on to demonstrate the clinical value of these concepts both for studying the session's microtransformations and as a means of in-depth examination of the analyst's own mental functioning, including its lapses, in a session. Abundant clinical material is presented to help analysts who normally apply different models of the mind share these ideas. Finally, it is suggested that night dreams result from a further elaboration of the elements formed during waking life.     

The effects of choice-making on the problem behaviors of high school students with intellectual disabilities

This investigation was conducted in an effort to systematically extend the emerging data base having to do with choice-making opportunities and the behavior of students with disabilities. In particular, the current analyses examined the effects of choice-making on the problem behavior and task engagement of three high school students with intellectual disabilities as the students performed domestic and vocational activities. Multiple baseline and reversal designs demonstrated that the choice conditions reduced problem behaviors and increased task engagement for all participants. Data having to do with student affect and task productivity were less consistent. The findings on the relationship between choice making and problem behavior replicate and extend a growing literature on the desirable effects of choice-making for individuals with disabilities. The results are discussed in terms of recent developments in behavioral support, as well as the need for ongoing conceptual and applied research.     

Evidence for the substantia nigra pars compacta as an essential component of a memory system independent of the hippocampal memory system

The aim of the present study was to test if the nigrostriatal pathway is an essential component for a water maze cued task learning and if it works independently of the hippocampal memory system. This hypothesis was tested using an animal model of Parkinson's disease in which male Wistar rats were lesioned in the substantia nigra pars compacta (SNc) by the intranigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), thus causing a partial depletion of striatal dopamine. SNc-lesioned and sham-operated animals were implanted bilaterally with guide cannulae above the dorsal hippocampus in order to be tested after the administration of 0.4 microl 2% lidocaine or saline into this structure. The animals were tested in a spatial or in a cued version of the water maze, memory tasks previously reported to model hippocampal-dependent spatial/relational and striatal-dependent S-R learning, respectively. Hippocampal inactivation, but not SNc lesion, impaired learning and memory in the spatial version of the water maze. An opposite situation was observed with the cued version. No significant interaction was observed between the SNc lesion and hippocampal inactivation conditions affecting scores in the spatial or in the cued version of the water maze. These results suggest that the nigrostriatal pathway is an essential part of the memory system that processes S-R learning and that it works independently of the hippocampal memory system that processes spatial/relational memories.     

Unity of analysis: similarities and differences in the analysis of children and grown-ups

When comparing child analysis with that of grown-ups, we are confronted with a substantial unity of psychoanalytic method, beyond the apparent differences. The more we consider the analysis as a here-and-now interaction between analyst and patient with transformative potential, the more age-dependent differences become blurred, and the specificity of a particular analytic couple acquires more significance. At the same time, what seems to be all the same--the actual patient before us--is quite different, with several components (the child, adolescent, and adult parts), implying a need to recognize the part we should address at any given point.