激活右腹外侧前额叶提高抑郁症患者对社会疼痛的情绪调节能力：一项TMS研究

负性人际交往经历和负性社会事件是抑郁症的重要诱导因素, 而社会功能受损是抑郁症患者的重要特征之一, 患者通常表现出对社会疼痛的情绪失调。为了提高抑郁症患者在负性社交情境中或面对负性社会事件时的情绪调节能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在腹外侧前额叶(the ventrolateral prefrontal cortex, VLPFC)被激活后其情绪调节能力的改变。结果表明, 当右侧VLPFC被TMS激活且患者采用认知重评策略调节情绪时, 实验组患者(n = 64)比对照组患者(n = 63)在社会排斥情境下报告了更弱的负性情绪体验, 这说明激活右侧VLPFC可以有效提高患者对社会疼痛的外显性情绪调节能力。本研究是采用TMS提高抑郁症患者情绪调节能力的首次尝试, 实验发现不但支持了VLPFC与认知重评策略的因果关系, 还为临床改善抑郁症等社会功能障碍患者的情绪调节能力提供了明确的神经治疗靶点。后续研究还需探讨多疗程TMS刺激方案、改变社会疼痛的诱发方式、对比左右侧VLPFC的治疗效果、尝试使用其他的情绪调节策略, 进一步验证本研究的结论, 优化TMS治疗方案。     

背外侧前额叶对主动遗忘负性社会反馈的作用：针对抑郁症的TMS研究

抑郁症患者的负性心境可能源于其抑制功能障碍。患者在主动遗忘负性材料时无法有效调用背外侧前额叶(the dorsolateral prefrontal cortex, DLPFC)等负责抑制控制的额叶脑网络。同时, 患者对社会信息的加工比对非社会信息的加工存在更明显的认知神经障碍, 很难主动遗忘对自己不利的社会反馈信息。为了提高抑郁症患者对负性社会反馈的主动遗忘能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在左侧(n = 32)或右侧DLPFC (n = 30)被激活后其记忆控制能力的改变。结果表明, 当患者的DLPFC被TMS激活时, 他们对社会拒绝的回忆正确率与健康对照组(n = 31)无差异, 且TMS激活右侧DLPFC还改善了患者对他人的社会态度。本研究是采用TMS提高抑郁症患者主动遗忘能力的首次尝试, 研究结果不但支持了DLPFC与记忆控制功能的因果关系, 还为临床治疗抑郁症、创伤后应激障碍、药物成瘾等患者的记忆控制缺陷提供了明确的神经靶点。     

视觉空间工作记忆组间差异的神经机制

为考察视觉空间工作记忆（working memory, WM）维持和操作的组间差异及其神经机制,本研究记录了高、低WM组完成延迟再认（维持）任务和心理旋转（操作）任务时的行为和事件相关电位数据。结果发现,在操作任务中,高WM组比低WM组的反应时显著更短;高WM组的中前额叶慢波显著更正、双侧后顶区慢波显著更负,并且两者的波幅显著负相关。在维持任务中,两组被试的反应时无显著差异;高WM组的中前额叶慢波显著更正。结果表明,高WM组的执行注意能力可能更强,能通过有效调节和分配加工资源来表征视觉信息。     

研究生入学考试写作评分的概化理论研究与多面Rasch分析

为了评价和改进硕士研究生入学考试一般能力测试的写作评分,研究者采用概化理论和多面Rasch分析对113位考生的写作样本的评分误差来源、评分信度等进行了探讨.概化理论研究显示,评分者和题目对评分准确性影响不大,以两道写作题的考试设计而言,评分者为2人即可保证评分信度在0.75以上.多面Rasch分析显示,评分者宽严度的估计值及其误差均在可接受的范围内,评分者之间在宽严度上不存在显著差异,且评分者自身在评分时总体上比较稳定.但个别评分者在特定考生特定题目上表现出特殊偏向.概化理论和多面Rasch分析丰富了写作评分研究的量化指标,证实了硕士研究生入学考试一般能力测试的写作评分具有较高的信度.     

The Mystery of Chinese People’s Happiness

The great improvement in economic wealth and social welfare over the decade doesn’t promote the Chinese people’s happiness. We construct a theoretical framework which covers economic wealth, social welfare, individual functional capability to explore the impact factors and determinants of the Chinese people’s happiness. Based on a national wide questionnaire survey in China, we test and modify the framework by the method of structural equation model. The empirical findings indicate that there are direct and indirect effects on the formation of happiness. For the direct effect, both the increasing of economic wealth and social welfare improves the national happiness, while the individual functional capability reduces it. For the indirect effect, the individual functional capability also reduces happiness by negatively affecting economic wealth and social welfare. The negative effect that played by individual functional capability overwhelms the positive effect played by economic wealth and social welfare. This causes the Chinese people’s happiness goes down while the economic wealth and social welfare are improving. Finally, we conclude that the Chinese people’s happiness is more about individual functional capability rather than social welfare or economic wealth.     

Cognitive diagnosis modelling incorporating item response times

To provide more refined diagnostic feedback with collateral information in item response times (RTs), this study proposed joint modelling of attributes and response speed using item responses and RTs simultaneously for cognitive diagnosis. For illustration, an extended deterministic input, noisy ‘and’ gate (DINA) model was proposed for joint modelling of responses and RTs. Model parameter estimation was explored using the Bayesian Markov chain Monte Carlo (MCMC) method. The PISA 2012 computer-based mathematics data were analysed first. These real data estimates were treated as true values in a subsequent simulation study. A follow-up simulation study with ideal testing conditions was conducted as well to further evaluate model parameter recovery. The results indicated that model parameters could be well recovered using the MCMC approach. Further, incorporating RTs into the DINA model would improve attribute and profile correct classification rates and result in more accurate and precise estimation of the model parameters.     

负性生活事件对初中生自我伤害行为的影响:有调节的中介效应

采用负性生活事件量表、自我批评量表、亲子关系量表和青少年自我伤害行为问卷对333名初中生进行测查,探讨负性生活事件对初中生自我伤害行为的影响及作用机制。结果表明:(1)负性生活事件对初中生的自我批评和自我伤害行为均有显著的正向预测作用;(2)自我批评在负性生活事件与初中生自我伤害行为之间起着部分中介作用;(3)负性生活事件和自我批评的关系(中介效应的前半段路径)受到亲子关系的调节,即负性生活事件对自我批评的正向影响随着父子关系和母子关系的增强而减弱。因此,负性生活事件和初中生自我伤害行为之间存在有调节的中介效应。     

抑郁症状阳性人群的初始沙盘特征

采用病例对照研究设计,探讨抑郁症状阳性人群初始沙盘特征。结果显示：抑郁症状阳性组在总数、动物、人物、建筑物、交通工具、植物类沙具使用少于对照组;抑郁症状阳性组沙盘空间领域使用少于对照组;抑郁症状阳性组在从哪里开始、对沙的态度、有无蓝色露底、是否使用桥、自己感觉是否满意、自我像是否在其中和主题场景上与对照组比较差异有统计学意义;沙盘主题特征回归分析显示进入抑郁症状阳性回归方程的沙盘主题特征变量有忽视、威胁、流动和能量。抑郁症状阳性人群在沙盘游戏中有特征性表现,初始沙盘具有临床心理评估的功能和价值。     

注意瞬脱效应的个体差异

注意瞬脱是指个体在对同一位置出现的多个刺激进行识别时, 如果第二个目标刺激出现在第一个目标刺激之后200~500 ms之间, 那么个体对第二个目标刺激的识别会显著降低的现象。研究表明, 注意瞬脱效应在健康人群中存在显著的个体差异, 主要表现在工作记忆、对分心刺激的抑制能力、意向聚焦、情绪状态和人格等方面。近年来, 注意瞬脱的个体差异也在多种神经疾病的临床研究中得到重视。未来的研究应更多关注注意瞬脱效应个体差异背后的神经机制以及应用研究。     

Association between cognitive vulnerability to depression - dysfunctional attitudes and glycaemic control among in-patients with type 2 diabetes in a hospital in Beijing: a multivariate regression analysis

This cross-sectional study aimed to investigate the relationship between glycosylated haemoglobin (HbA1c) and cognitive vulnerability to depression (dysfunctional attitudes) in patients with type 2 diabetes mellitus. A total of 245 valid records from June 2016 to December 2016 were collected from a hospital in Beijing. Participants were asked to complete four questionnaires (Dysfunctional Attitudes Scale, Automatic Thoughts Questionnaire, Zung Self-rating Depression Scale, and World Health Organization Quality of Life Instrument-Short Form) to assess mental health and quality of life. Multivariate regression analysis was conducted to determine the correlations between HbA1c, mental health, quality of life and other clinical variables. The results showed that dysfunctional attitudes were associated with HbA1c, with a standardized regression coefficient (β) of .13 (p = .01), although 1 h C-peptide (β = ?.75, p < .0001) was the most significant predictor of HbA1c in the regression model. The results indicated that dysfunctional attitudes, as a cognitive vulnerability to depression, were a relevant factor in HbA1c, although further studies are needed to establish the nature of the connection between dysfunctional attitudes and glycaemic control in diabetes patients.