EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD-25) ON NORMAL SUBJECTS IN A SCHIZOPHRENIA-DISCRIMINATING TEST BATTERY

Psychological tests with differing sensitivity to schizophrenic reactions were administered to eight normal subjects after oral intake of 75–100 μ g LSD-25. Control data were obtained from placebo trials. Six of the tests were chosen as sensitive to schizophrenic reactions, two tests as so-called 'hold' tests, and another test as a measure of attention, which is supposed to be reduced by LSD. Significantly lower results were obtained on four of the six sensitive tests after LSD, on one of the 'hold' tests, and on the attention test.     

STUDIES IN THE PSYCHOLOGICAL EFFECTS OF A NEW DRUG (DIETHYLPROPION)

In a 'triple blind' study on 30 subjects, 50 mg diethylpropion was compared with 10 mg dexamphetamine, 50 mg phenmetrazine, 250 mg caffeine, and placebo. The effects were measured in 5 subjective variables at 40 minutes intervals up to 4 hours. Clear trends were obtained in 'happiness', 'alertness' and 'pleasantness'. Peak effects were seen at about two hours, but in pleasantness the effects of phenmetrazine were increased even after that time. The demonstrated effects were discussed in relation to data on abuse of diethylpropion and phenmetrazine.     

FACTOR ANALYSIS OF A NEUROTICISM INVENTORY

The Lidvall neuroticism inventory is comprised of 25 questions referring to symptoms presumed to be connected with manifest neurotic anxiety. It was presented to 377 persons, an unscreened group with respect to neurotic symptoms, and a factor analysis with rotation to simple structure was performed.—Four factors could be identified: (1) manifest neurotic anxiety, (2) neurotic difficulties in interpersonal relations, (3) neurasthenic symptoms and (4) obsessive-compulsive symptoms. The factor scales were correlated with Neuroticism and Extraversion in MPI. Neuroticism was shown to be a heterogeneous factor. The correlation between Factor (2) and Extraversion was high.