Suppression of corticosterone synthesis alters the behavior of hippocampally lesioned rats

The suppression of corticosterone synthesis with metyrapone (25 mg/kg) reduced the hyperactivity and altered the exploratory activity of hippocampally lesioned animals (HPC) in the open field to the level of cortical and sham controls (Experiment 1). In a second experiment, corticosterone (600 micrograms/kg) pretreatment 2 h, but not 1 h, before metyrapone partially restored the hyperactivity of HPC animals that had been decreased by the corticosteroid-suppressant drug. Alterations in exploratory behavior induced by metyrapone were also prevented by corticosterone pretreatment. The results suggest that the suppression of corticosterone in hippocampally lesioned animals produces a normalization of behavior that can be prevented by pretreatment with corticosterone.     

The Role of Maternal Acceptance in the Relation Between Community Violence Exposure and Child Functioning

Children in the United States are exposed to considerable community violence that has been linked to child functioning. However, not all those exposed, experience negative outcomes. Recent research has focused on factors that “buffer” or protect children from negative consequences of violence exposure. The purpose of this investigation was to examine the potential buffering or moderating role of maternal acceptance in the relationship between community violence exposure and internalizing and externalizing problems. Subjects were 268 urban African American first graders. Community violence exposure was significantly related to symptoms of post-traumatic stress, but did not correlate with either internalizing or externalizing problems for all children, after control for demographics, maternal mental health, and general life stress. However, children's perceptions of maternal acceptance moderated the relationship between violence exposure and internalizing and externalizing problems which included being withdrawn, anxious-depressed, and demonstrating delinquent behavior. Children with the lowest levels of self-reported maternal acceptance were most impacted by community violence. In this sample of urban first graders, low levels of maternal acceptance placed children at greater risk for adverse outcomes associated with community violence exposure compared to moderate and high levels of maternal acceptance.     

Age- and sex-related induction of excessive grooming and "wet-dog" shakes by the codeinone RX 336-M in the rat

Peripheral administration of the dihydrocodeinone RX 336-M (6 mg/kg) stimulated vigorous "wet-dog" shakes and excessive grooming in young drug-naive rats. The effects of RX 336-M were greater in younger than in older animals of both sexes, and were greater in 39-day-old male rats than in female rats of the same age. In a second experiment, female rats were pretreated with testosterone benzoate (1 mg/kg/day) for 1 week prior to testing the effects of RX 336-M at 39 days of age. The sex hormone pretreatment enhanced the ability to RX 336-M to induce "wet-dog" shakes and excessive grooming in female rats. The results suggest that both sex- and hormone-dependent developmental status are critical in the display of the so-called "quasi-morphine withdrawal syndrome." The results imply, and are consistent with previous studies which suggest, that different neural mechanisms underlie the behavioral responses induced by ACTH and RX 336-M.     

The effects of episodic and semantic memory on the identification of sentences masked by white noise

Two studies examine how episodic and semantic memory affect subjects’ abilities to repeat sentences masked by white noise. Subjects first hear a list of 70 sentences that are not masked. Subjects in the framework conditions are told prior to hearing the list that all sentences refer to a contextual framework concerning a deserted island. Subjects in the no-framework groups are not given this information. Subjects in the framework-after condition are given this information only after hearing the list of sentences. Subjects then perform a white-noise identification task. The results indicate that framework subjects are able to identify both old and new framework-related information better than other subjects. Subjects in the no-framework and framework-after conditions identify old information better than control subjects who do not participate in an acquisition phase. Emphasis is placed on the interdependence of episodic and semantic memory, including conditions leading to such interdependence.     

Auditory backward-masking performance by children who stutter and its relation to dysfluency rate

The fluency of people who stutter is affected markedly when auditory feedback is altered, suggesting that stuttering may be associated with hearing. Peripheral hearing problems, however, are no more common in people who stutter than in those who do not. Performance was investigated in a task that involves central auditory processing (backward masking). Children who stuttered had deficits in backward masking (indicated by higher thresholds) compared with a group of fluent control children. The backward-masking thresholds were positively correlated with frequency of stuttering.     

False memories for compound words: Role of working memory

Subjects studied pairs of compound words; pair members were presented simultaneously (one above the other) for 2 sec or sequentially (one immediately following the other) for 1 sec each, and 6-sec interstimulus intervals separated the end of presentation of one pair and the start of that of another. A subsequent recognition test included within-pair and between-pair conjunction foils (recombinations of stimulus parts from the same study pair and from separate pairs, respectively). Previous experiments using faces as stimuli have demonstrated that when faces are presented simultaneously there are many more false alarms to within-pair than to between-pair conjunction items, and when faces are presented sequentially there is an equal number of false alarms in those two conditions. However, Experiment 1 showed that for compound word stimuli there were equally high false alarm rates toboth types of foils in both study conditions relative to completely new test items. Experiment 2 showed that when rehearsal of compound words was prevented, the pattern of conjunction errors was very similar to the one typically obtained for faces. In Experiment 3, subjects falsely recalled conjunctions of within-pair compound words but not conjunctions of between-pair words in the simultaneous-study condition; no conjunctions were recalled in the sequential-study condition. The results support the idea that working memory processing is necessary for binding stimulus parts together in episodic memory.     

On the Misrecognition of Identity: Muslims' Everyday Experiences in Scotland

Political theory is interested in the misrecognition of identity because it impacts individuals' autonomy in their self-definition and thus their ability to articulate and pursue identity-related interests. Here, we explore minority group members' experiences of being seen in terms that do not accord with their self-definition. Our data are qualitative, gathered through walking interviews with 24 Muslims in Scotland. Focusing on interactions in which they reported discrepancies between how they and others saw them, we differentiate four forms of misrecognition: (1) having the meaning of a valued identity (i.e., one's Muslim identity) defined by others in ways that one judges inaccurate and inappropriate; (2) having one's membership of a valued community (e.g., as a member of Scottish society) denied or rejected; (3) having one's identity (i.e., one's Muslim identity) overlooked such that one's distinctive identity-related needs are not taken into account; (4) being seen in terms of just one of one's many social identities (i.e., one's Muslim identity) such that other identities (judged more situationally relevant) are ignored. This empirically grounded typology contributes to wider debates about the forms of identity (mis)recognition and their political implications.     

A failure to replicate rapid syntactic adaptation in comprehension

Language comprehension requires successfully navigating linguistic variability. One hypothesis for how listeners manage variability is that they rapidly update their expectations of likely linguistic events in new contexts. This process, called adaptation, allows listeners to better predict the upcoming linguistic input. In previous work, Fine, Jaeger, Farmer, and Qian (PLoS ONE, 8, e77661, 2013) found evidence for syntactic adaptation. Subjects repeatedly encountered sentences in which a verb was temporarily ambiguous between main verb (MV) and reduced relative clause (RC) interpretations. They found that subjects who had higher levels of exposure to the unexpected RC interpretation of the sentences had an easier time reading the RC sentences but a more difficult time reading the MV sentences. They concluded that syntactic adaptation occurs rapidly in unexpected structures and also results in difficulty with processing the previously expected alternative structures. This article presents two experiments. Experiment 1 was designed as a follow-up to Fine et al.’s study and failed to find evidence of adaptation. A power analysis of Fine et al.’s raw data revealed that a similar study would need double the items and four times the subjects to reach 95% power. In Experiment 2 we designed a close replication of Fine et al.’s experiment using these sample size guidelines. No evidence of rapid syntactic adaptation was found in this experiment. The failure to find evidence of adaptation in both experiments calls into question the robustness of the effect.     

Altered grooming responses to stress in rats exposed prenatally to ethanol

The effects of prenatal alcohol exposure on grooming, locomotion, and rearing in response to stress were examined in adult rats whose mothers consumed a liquid diet containing 35% ethanol-derived calories (EDC). Offspring of both pair-fed 0% EDC mothers and ad libitum chow-fed mothers were included as controls. In Experiment 1, females groomed more than males following placement into a novel test chamber, but no differences due to prenatal treatment were observed. Ethanol-exposed animals groomed more than controls following the stress of a forced 1-min swim (Experiment 2), but when rats tested in Experiment 1 were observed again after forced swim stress (Experiment 3), no differences due to prenatal treatment or sex were observed. Experiment 4 examined the effects of pretreatment with 1 mg/kg naloxone on novelty-induced grooming and as in Experiment 1 prenatal treatment did not affect grooming responses. Females again groomed significantly more than males and naloxone reduced grooming equally for all groups. The results suggest that novelty-induced grooming is a sex-influenced behavior, with females grooming more than males, and that animals exposed prenatally to alcohol and tested as adults may have altered responses to certain stressors (i.e., forced swim) under specific conditions. The altered grooming response of alcohol-exposed rats to swim stress can be eliminated by preexposing them to novelty stress.