BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure

Post-traumatic stress disorder (PTSD) is a syndrome resulting from exposure to a severe traumatic event that poses threatened death or injury and produces intense fear and helplessness. The neural structures implicated in PTSD development belong to the limbic system, an important region for emotional processing. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as survival factor for selected populations of central nervous system (CNS) neurons and plays a role in the limbic system by regulating synaptic plasticity, memory processes and behavior. Impaired BDNF production in the brain can lead to a variety of CNS dysfunctions including symptoms associated with PTSD. However, so far fewer studies have investigated this neurotrophin in patients with PTSD. Furthermore, given the multiple role of BDNF in various CNS disorders, it cannot be excluded that traumatic events per se may influence neurotrophin levels, without a direct association to the PTSD syndrome.     

Cortical memory mechanisms and language origins

We have previously proposed that cortical auditory-vocal networks of the monkey brain can be partly homologized with language networks that participate in the phonological loop. In this paper, we suggest that other linguistic phenomena like semantic and syntactic processing also rely on the activation of transient memory networks, which can be compared to active memory networks in the primate. Consequently, short-term cortical memory ensembles that participate in language processing can be phylogenetically tracked to more simple networks present in the primate brain, which became increasingly complex in hominid evolution. This perspective is discussed in the context of two current interpretations of language origins, the "mirror-system hypothesis" and generativist grammar.     

The Effect of Perspective‐Giving on Postconflict Reconciliation. An Experimental Approach

Discussion groups are a promising tool for bridging the divide between former conflict antagonists. However, such groups do not always produce the desired outcome of improved attitudes, even when they meet the conditions generally seen as favoring positive interaction. In this article, we examine specific discussion protocols that mitigate polarization risks while fostering reconciliation. Using a randomized, controlled design, we formed a pool of 429 ex‐combatants and members of conflict‐affected communities in Colombia. Participants were asked to join heterogeneous groups and discuss their proposals for the future of Colombia. Overall, community members improved their attitudes towards ex‐combatants significantly, while ex‐combatants’ attitudes toward community members do not tend to polarize. Those participants who were randomly assigned to a perspective‐giving treatment protocol (where they were asked to refer to their personal experience and perspective) consistently improved their intergroup attitudes towards ex‐combatants, and by a proportionally higher percentage than those taking part under argumentation and no‐treatment control conditions.     

Gender effects among undergraduates relating to suicide risk, impulsivity, aggression and self-efficacy

The present study investigated the association of impulsivity, aggression and self-efficacy with protective factors against suicide. The study population consisted of 300 Italian university students (141 males, 159 females); mean age 24.2 (SD = 3.01). Participants were assessed by means of the Reasons for Living Inventory, the Aggression Questionnaire, the Barratt Impulsiveness Scale, and the General Self-Efficacy Scale. Correlations between reasons for living and aggression and impulsivity scores were weak. However, for those individuals with high self-efficacy, aggression and impulsivity were associated with stronger reasons for living. These results support the possibility that increasing general self-efficacy could be a useful target for interventions directed toward suicide prevention in individuals with problems in emotional control.     

The Exemption that Confirms the Rule: Reflections on Proceduralism and the UK Hybrid Embryos Controversy

This paper provides an interpretation of the licensing provisions envisaged under the Human Fertilisation and Embryology Act 1990 as a model for a rule and exemption-based procedural strategy for the adjudication of potential ethical controversies, and it offers an account of the liberal-democratic legitimacy of the procedure’s outcomes as well as of the legal procedure itself. Drawing on a novel articulation of the distinction between exceptions and exemptions, the paper argues that such a rule and exemption mechanism, while not devoid of attractions, is not immune from the criticisms often levied against procedural approaches to the management of pluralism: it either has to fall back on substantive justification in ways that are not helpful when trying to arbitrate a moral controversy, or it appears justificatorily groundless.