Attenuation of Hippocampal 11beta-Hydroxysteroid Dehydrogenase Type 1 by Chronic Psychosocial Stress in the Tree Shrew

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone, thus regulating glucocorticoid access to intracellular receptors. In rats, chronic glucocorticoid excess or stress increases 11beta-HSD-1 in the hippocampus, producing suggestions that it may attenuate the deleterious effects of chronic glucocorticoid excess. However, 11beta-HSD-1 predominantly catalyses 11beta-reduction in the intact liver and hippocampal cells, thus regenerating active glucocorticoids from inert substrate. We studied 11beta-HSD activity in the tissues of male tree shrews following 28 days of sustained psychosocial stress or exogenous administration of cortisol. In the hippocampus, chronic psychosocial stress attenuated 11-HSD-1 activity (69 +/- 9% of control), whereas cortisol alone had no effect. In the liver, both chronic stress and cortisol administration decreased 11beta-HSD-1 activity (47 +/- 11% and 49 +/- 4% fall, resp.). Attenuation of 11beta-HSD-1 within tissues may reflect a homeostatic mechanism designed to minimise the adverse effects of prolonged stress and/or glucocorticoid excess.     

Lateralization of two-transient stimuli

In this study of the precedence effect in binaural hearing, subjects adjusted the interaural delay of a wideband acoustic pointer to match the perceived intracranial position of transient test stimuli presented over headphones. The test stimuli had leading and lagging components (either brief noise bursts or clicks), each with its own interaural delay. In some test conditions, the leading and lagging stimuli were coherent copies of one another, whereas in others, they were independent samples of noise. The duration of the stimuli and the delay from the leading component to the lagging component were also varied. All the stimulus conditions showed a moderate or strong precedence effect (i.e., covariation of perceived lateral position of the composite two-transient stimulus with the interaural delay of the leading component). Predictions of the lateralization data are presented for variants of models based on temporal weighting and/or bandpass correlation. In one model variant, the binaural stimuli are temporally weighted to emphasize the onset and then subjected to bandpass correlation analysis. In another variant, it is assumed that the onset mechanism provides a rough estimate of the initial interaural delay that guides a slower and more focused bandpass correlation analysis. The accuracies of these two model's predictions were equivalent and superior to those of models that either represent leading and lagging cues equally (bandpass correlation with no onset effect) or do not represent lagging cues at all (a complete precedence effect). The results of these analyses show the need for both a strong onset effect and for bandpass correlation analysis and suggest two modeling approaches for achieving that goal.     

Support Groups for Suicide Survivors: Results of a Survey of Group Leaders

To update and expand Rubey and McIntosh's (1996) survivors of suicide support groups report, SPAN USA completed a survey of U.S. support group leaders (n = 100; 24% completion). There are now more survivor groups (from 280 to 417), and the majority of groups now have a survivor leader (78% vs. 25%). Groups continue to be small (88% < 10 members per session) and meet on a monthly basis (55%). Sharing continues to be a universal experience in groups, which tend to be open‐ended (85%). Current groups are newer, and more operate without a sponsor. Further research is needed to examine group member perspectives and effectiveness of groups.     

Youth Media Lifestyles

In this article, the concept of “media lifestyles” is adopted in order to develop a comprehensive approach toward youth engagement in communication media. We explore how 503 Dutch eighth grade students with full access to new technology combine a broad range of media by focusing on their engagement with media while taking various contexts of use into account. Four different media lifestyles of media omnivores, networkers, gamers, and low‐frequency users are described. Furthermore, we show how the methodology we used is able to provide more insight into how the distinguished media lifestyles were codetermined by particular media, functions and social contexts. Finally, the implications for the Uses & Gratifications theory are discussed.