Effects of differential interference with postnatal cerebellar neurogenesis on motor performance, activity level, and maze learning of rats: a developmental study

The region of the cerebellum was X-irradiated in infant rats with selected exposure schedules designed to produce animals in which the cerebellar cortex was (a) essentially normal except for agenesis of late forming granule cells with axons situated in the uppermost molecular layer (12--15X), (b) lacking in stellate cells, with a severe reduction in granule cells with axons in the upper molecular layer (8--15X), (c) morphologically disorganized but had only intermediate cell agenesis (4--5X), or (d) disorganized and devoid of practically all postnatally forming interneurons (4--15X). In the first two experiments young adults had to traverse rotating rods that differed in texture and types of obstacles. The 8--15X animals showed no deficits on any of the rods tested. The third study dealt with spontaneous motor performance in the open field at three ages. The 4--5X and 4--15X animals were hypoactive as infants and young adults; this was attributed to their motor deficits. The 8--15X and 12--15X animals were hyperactive in the open field as young adults. The fourth experiment examined intra- and/or intersession habituation. No group differences were found in habituation patterns. In the fifth experiment, using activity wheels, the 4--15X group was hypoactive, and the 8--15X and 12--15X groups were hyperactive as young adults. In the sixth experiment young adults were tested for learning performance in a multiple-unit water maze. The 4--15X group was deficient on single alternation; the 4--5X and 12--15X groups on double alternation. The seventh experiment shed some light on the single alternation deficit of the 4--15X group; only these animals failed to alternate spontaneously in a nonaversive situation. In conclusion, these behavioral results, combined with those of recent morphological investigations, suggest that the cerebellar cortex is hierarchically organized: The basal domain of Purkinje cells and the lower molecular layer are implicated in the coordination of movements; the apical domain of Purkinje cells and the upper molecular layer, in the coordination of actions.     

Helping is not enough: Recipient's reactions to aid as a function of positive and negative information about the self

The present research investigated the effects of experimentally induced positive and negative feedback about the self on the recipient's subsequent reactions to aid. In line with a consistency prediction, subjects given positive feedback who later received aid had lower mood ratings and less favorable self-evaluations than those who were given positive feedback but no subsequent help. Conversely, subjects given negative feedback who later received aid had higher mood ratings and more positive self-evaluations than those who were given negative feedback but no subsequent help. Subjects' evaluations of another individual were characterized by aid main effects, which indicate that an other who helped was evaluated more favorably than an other who did not help. The conceptual and applied implications of these results are discussed.     

Out of the Blue: Reflections on a Shared Trauma

Richard Almond’s paper challenges us to think deeply about the analyst’s impactful desires on the patient. My discussion considers different aspects of this impact: phallic, maternal, ethical. Specifically, I assert that Almond’s position in relation to the female patients he describes is more maternal, or “matricial,” than phallic. Chetrit-Vatine’s concept of matricial space is used to elucidate this point. Further, Almond’s paper asks us to consider seriously psychoanalysis as an ethics regarding responsibility for desire as it relates to countertransference and enactment. The specific desire I focus on is Almond’s desire for his patients’ love. Such as desire involves inherent clinical difficulties.