Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Demand for Space: Elderly Transgender and Gender Nonconforming People,Healthcare, and Theological Ethics

Journal of Religion and Health - Visibility for transgender and gender nonconforming people and the elderly is growing; however, thus far the overlap of the two groups has rarely been considered....     

Feature binding contributions to effect monitoring

Monitoring the perceptual effects of body movements is supposed to be a capacity-limited process that can interfere with processing of a concurrent task. Here we studied the contribution of feature binding to such effect monitoring interference. In three experiments, we varied the possibility of feature overlap between responses and effects in a primary task and responses in a secondary task. We show that responses in a secondary task are delayed when they partially, rather than completely, alternate or repeat features of responses/effects of a primary task. Yet, these partial feature repetition/alternation costs are small, and they occur on top of other factors that lengthen the critical effect monitoring process, such as the spatial compatibility of responses and effects in the primary task. The results thus show that feature binding contributes to, but cannot fully account for, delays in a secondary task caused by monitoring effects of a primary task.

     

Structural Equation Modeling of Spatial Presence: The Influence of Cognitive Processes and Traits

This article examines the formation process of spatial presence, which is conceived as a two-step process involving the construction of a mental model of the mediated environment, followed by the emergence of spatial presence. During both stages, cognitive processes and user traits are in effect. We present data derived from a pooled set of data of three studies using the same virtual environment. Structural equation modeling is used to confirm the proposed theoretical model. The results show that attention and the trait of visual spatial imagery are positive predictors of the mental model of the mediated environment. In the second step, the formation of spatial presence is governed by involvement, the suspension of disbelief, and the domain-specific interest, together with the mental model.     

Family Dynamics and AIDS Phobia: A Case Study

The author introduces and defines AIDS phobia. He illustrates the hypochondria type of AIDS phobia from a combined individual, couple, and family treatment perspective. He describes the treatment process and outcome after an effective countertransference-based intervention, connects the individual manifestations of the index patient's illness to the family dynamics, and concludes with an analysis of the multigenerational contributions to the individual's psychopathology.     

EVIDENCE THAT GENDER DIFFERENCES IN SOCIAL DOMINANCE ORIENTATION RESULT FROM GENDERED SELF-STEREOTYPING AND GROUP-INTERESTED RESPONSES TO PATRIARCHY

Numerous studies have found that, compared to women, men express higher levels of social dominance orientation (SDO), an individual difference variable reflecting support for unequal, hierarchical relationships between groups. Recent research suggests that the often-observed gender difference in SDO results from processes related to gender group identity. We hypothesized that two aspects of gender group identity could account for men's higher SDO relative to women's: responses to patriarchy that reflect the interests of the gender ingroup (as measured by hostile and benevolent sexism) and self-stereotyping in gendered terms. We found the gender difference in SDO was fully mediated by gender differences in feminine self-stereotyping, hostile sexism, and benevolent sexism. The discussion addresses implications for social dominance theory's treatment of gender and the complexity of social-contextual forces that produce gender differences in SDO.     

Avoidance of 20% carbon dioxide-enriched air with humans.

Four college students were exposed to a Sidman avoidance procedure to determine if an avoidance contingency involving 20% carbon dioxide-enriched air (CO2) would produce and maintain responding. In Phase 1, two conditions (contingent and noncontingent) were conducted each day. These conditions were distinguished by the presence or absence of a blue or green box on a computer screen. In the contingent condition, CO2 presentation were delivered every 3 s unless a subject pulled a plunger. Each plunger pull postponed CO2 presentations for 10 s. In the noncontingent condition, CO2 presentations occurred on the average of every 5 min independent of responding. Following stable responding in Phase 1, condition-correlated stimuli were reversed. In both conditions, plunger response rate was high during the contingent condition and low or zero during the noncontingent condition. Furthermore, subjects avoided most CO2 presentations. However, CO2 presentations did not increase verbal reports of fear. Overall, the results from the present study suggest that CO2 can be used effectively in basic studies of aversive control and in laboratory analogues of response patterns commonly referred to as anxiety.     

Rule-violations sensitise towards negative and authority-related stimuli

Rule violations have usually been studied from a third-person perspective, identifying situational factors that render violations more or less likely. A first-person perspective of the agent that actively violates the rules, on the other hand, is only just beginning to emerge. Here we show that committing a rule violation sensitises towards subsequent negative stimuli as well as subsequent authority-related stimuli. In a Prime-Probe design, we used an instructed rule-violation task as the Prime and a word categorisation task as the Probe. Also, we employed a control condition that used a rule inversion task as the Prime (instead of rule violations). Probe targets were categorised faster after a violation relative to after a rule-based response if they related to either, negative valence or authority. Inversions, however, primed only negative stimuli and did not accelerate the categorisation of authority-related stimuli. A heightened sensitivity towards authority-related targets thus seems to be specific to rule violations. A control experiment showed that these effects cannot be explained in terms of semantic priming. Therefore, we propose that rule violations necessarily activate authority-related representations that make rule violations qualitatively different from simple rule inversions.