The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

Indicators of Affect Dynamics: Structure,Reliability, and Personality Correlates

Researchers are increasingly interested in the affect dynamics of individuals for describing and explaining personality and psychopathology. Recently, the incremental validity of more complex indicators of affect dynamics (IADs; e.g. autoregression) has been called into question (Dejonckheere et al., 2019), with evidence accumulating that these might convey little unique information beyond mean level and general variability of emotions. Our study extends the evidence for the construct validity of IADs by investigating their redundancy and uniqueness, split-half reliability based on indices from odd-numbered and even-numbered days, and association with big five personality traits. We used three diverse samples that assessed daily and momentary emotions, including community participants, individuals with personality pathology, and their significant others (total N = 1192, total number of occasions = 51 278). Mean and variability of affects had high reliability and distinct nomological patterns to big five personality traits. In contrast, more complex IADs exhibited substantial redundancies with mean level and general variability of emotions. When partialing out these redundancies by using residual variables, some of the more complex IADs had acceptable reliability, but only a few of these showed incremental associations with big five personality traits, indicating that IADs have limited validity using the current assessment practices. © 2020 The Authors. European Journal of Personality published by John Wiley & Sons Ltd on behalf of European Association of Personality Psychology     

Ethanol reduces rCFB activation of left dorsolateral prefrontal cortex during a verbal fluency task

In a previous study in normal subjects (Wendt et al., 1994), using a reversing checkerboard as activation stimulus, we found that the coupling between local neuronal activity and regional cerebral blood flow was preserved following ethanol, and that a right-sided occipital activation response seen during sobriety became symmetrical during inebriation. In the present study we investigated if ethanol has a detrimental effect also on the activation of the left dorsolateral prefrontal cortex found in normals during verbal fluency. Measurements of regional cerebral blood flow in 20 healthy, young, male, right-handed volunteers during rest and verbal fluency were made during sobriety and inebriation (0.06% blood alcohol concentration) with a 1-week interval. We found a decrease in word production during inebriation. The normal activation within the frontotemporal part of the left dorsolateral prefrontal cortext was preserved during inebriation. The activation of this region seems thus to be robust to the effects of ethanol. During inebriation no activation response to the word fluency test was found in the anterior prefrontal part of the dorsolateral prefrontal cortex. This region is important for working, temporal, and short-term memory functions, processes that are affected by ethanol. Hemispheric functioning and specialization seem to be adversely affected by ethanol, regardless of which hemisphere is most involved while sober.     

Brain activation during spatial updating and attentive tracking of moving targets

Keeping aware of the locations of objects while one is moving requires the updating of spatial representations. As long as the objects are visible, attentional tracking is sufficient, but knowing where objects out of view went in relation to one's own body involves an updating of spatial working memory. Here, multiple object tracking was employed to study spatial updating and its neural correlates. In a dynamic 3D-scene, targets moved among visually indistinguishable distractors. The targets and distractors either stayed visible during continuous viewpoint changes or they turned invisible. The parametric variation of tracking load revealed load-dependent activations of the intraparietal sulcus, the superior parietal lobule, and the lateral occipital cortex in response to the attentive tracking task. Viewpoint changes with invisible objects that demanded retention and updating produced load-dependent activation only in the precuneus in line with its presumed involvement in updating spatial working memory.     

Adolescents' relationships with mother and father and their links to the quality of romantic relationships: A classification approach

Adolescents' relationships with parents are considered to be a major learning source and emotional base for developing expectations and styles of behaviour in close relationships. Using a longitudinal sample of late adolescents from nuclear families drawn from the German Family Panel pairfam (N = 720; mean age: 18.6 years), we investigated how adolescents' relationships with both parents influenced their romantic relationship quality one year later. Bagged (Averaged) Binary Recursive Partitioning was used to compare features of adolescents' relationships with mother and father (relatedness, negative conflict, emotional insecurity, and parental dominance) in respect of their importance in predicting similar aspects of romantic relationship quality. Overall, our findings suggest some degree of domain-specific continuities in adolescents' relationships with parents and partner, particularly for negative conflict, as well as more global effects for most features of the parent–adolescent relationship. Emotional insecurity with mother was most broadly linked to all features of adolescents' romantic relationship. Overall, adolescents' relationship with mother was found to be more influential than their relationship with father. The findings are discussed with reference to a behavioural systems perspective and attachment theory.     

The impact of politeness and relationship on perceived quality of advice about a problem

Advice is a common but potentially problematic way to respond to someone who is distressed. Politeness theory (Brown & Levinson, 1987) suggests advice threatens a hearer's face and predicts that the speaker‐hearer relationship and the use of politeness strategies can mitigate face threat and enhance the effectiveness of advice messages. Students (N=384) read 1 of 16 hypothetical situations that varied in speaker power and closeness of the speaker‐hearer relationship. Students then read 1 of 48 advice messages representing different politeness strategies and rated the message for regard shown for face and for effectiveness. However, neither speaker‐hearer relationship nor politeness strategies was consistently associated with perceived threat to face or perceived advice effectiveness. We suggest revisions to politeness theory and additional factors that may affect judgments of face sensitivity and advice effectiveness.     

Group round]

The traditional clinical round as a means of communication, information and teaching has considerable disadvantages; therefore a procedure is proposed after 5-years testing called "group round" as a supplementary procedure. It spares the time of the physician, enables the orientation in the individual patient and moreover the observation of interaction between the patients themselves and between patients and personal staff and facilitates teaching. The less experienced physician gets an easier approach to group psychotherapy, essential effects of which become effective in the procedure. The breaking of professional secrecy can be avoided.     

Fitness for automobile driving of patients at an epilepsy outpatient care unit

Patients who were free from seizures and not in possession of a driving license were examined for reasons for their being considered unfit to drive at an outpatient care centre for epileptics catering for 477 patients. The composition of the group was analyzed in respect of age, sex, intake of pharmaceuticals, risk factors and appropriateness of behaviour in traffic. Corresponding conclusions are drawn.