BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure

Post-traumatic stress disorder (PTSD) is a syndrome resulting from exposure to a severe traumatic event that poses threatened death or injury and produces intense fear and helplessness. The neural structures implicated in PTSD development belong to the limbic system, an important region for emotional processing. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as survival factor for selected populations of central nervous system (CNS) neurons and plays a role in the limbic system by regulating synaptic plasticity, memory processes and behavior. Impaired BDNF production in the brain can lead to a variety of CNS dysfunctions including symptoms associated with PTSD. However, so far fewer studies have investigated this neurotrophin in patients with PTSD. Furthermore, given the multiple role of BDNF in various CNS disorders, it cannot be excluded that traumatic events per se may influence neurotrophin levels, without a direct association to the PTSD syndrome.     

Multiple schedules of conjugate reinforcement and extinction: A translational model for assessing automatically reinforced behavior

This study evaluated the extent to which a conjugate reinforcement schedule (CONJ) involving a contingency between pedaling a stationary bike and viewing a preferred movie could serve as a translational preparation for the analysis of automatically reinforced behavior. In part, researchers examined whether providing participants with either an accurate or an inaccurate rule about the extinction (EXT) component of a multiple schedule (MULT) contributed to the development of control by the MULT (CONJ EXT) schedule. Results show schedule control emerged for four of five participants who received the accurate rule and none of the five participants who received the inaccurate rule. In addition, participants who received accurate rules typically increased pedaling during CONJ components that followed two consecutive EXT components, suggesting that they experienced deprivation for audio and visual stimulation generated by pedaling. These preliminary findings suggest that researchers could use this translational preparation to identify matched interventions for some automatically reinforced behavior.     

The scientific turn in metaphysics: a factualist approach

In a recent paper, Cumpa (Am Philos Q 51(4): 319–324, 2014) argues that a scientific turn in metaphysics requires the acceptance of a materialist criterion of fundamentality, according to which the most fundamental metaphysical category is the one that provides us with a reconciliation of the ordinary world and the physical universe. He concludes that the dominant category of substance cannot be the most fundamental category, for it does not satisfy this criterion of fundamentality. The most fundamental category is instead the category of fact. Although convincing, the defense of factualism over substantialism offered by Cumpa takes into account the case of classical physics without considering the physical universe of quantum mechanics. My aim in this paper is to offer a completion to Cumpa’s factualist approach. To achieve my aim, I show that substances cannot provide a satisfactory account of the relationship between the ordinary world and the physical universe even in the case of quantum mechanics, whereas a factualist approach does.

     

Assessing the automaticity of the exogenous orienting of tactile attention

We examined whether or not abrupt tactile onsets are capable of exogenously capturing tactile spatial attention when visual spatial attention is focused elsewhere. In experiment 1, we compared performance under dual-task conditions (where participants performed a tactile exogenous cuing task and a rapid serial visual presentation--RSVP--task at the same time) with their performance under single-task conditions (where the participants had to perform only the cuing task, although the RSVP stream was still presented in the background) and to a no-stream condition (where only the cuing task was presented). Tactile cuing was completely suppressed in both the dual-task and single-task conditions, showing that exogenous tactile spatial orienting is modulated by visual-spatial attention, which hence appears to be far from truly automatic. In experiment 2, we demonstrated that the abolishment of exogenous tactile orienting was not caused by the transient presentation of abrupt onset stimuli (letters). These results therefore show that exogenous spatial attentional orienting toward abrupt peripheral tactile stimuli is possible as long as perceptual resources are not depleted by a perceptually demanding (RSVP) task.     

A self-capitalization model for building behavior analysis graduate programs

The development of the Behavior Analysis Program at the University of Nevada through self-capitalization is described. With this model, both doctoral and master's degree programs were established at almost no cost to the university. Some of the problems encountered along the way, including gaining support for the original proposal, attracting and retaining high-quality faculty, engendering support from the Department of Psychology and the university, developing resources, and balancing academic with entrepreneurial demands are discussed, as are the solutions we have found for those problems.     

De-polarizing verbal irony

In three studies participants were asked to rate the degree of irony perceived in comments relating to five variations of a scenario, ranging from one pole to the opposite pole and passing through three in-between states. In study 1, the comments pertained to the polar extremes of a dimension, e.g. “It’s uphill!” stated with reference to varying degrees of steepness both uphill and downhill (i.e. steep, slightly steep, flat, slightly sloping downhill and steeply sloping downhill). In study 2, the comments were of an “intermediate” nature (e.g. “This hill is neither uphill nor downhill!”) and, as in Study 1, they were used to refer to the same five varying degrees of the same dimension. Study 3 involved the stimuli from both of the first two experiments in a between-participants design.

The results consistently demonstrated that verbal irony does not only apply to (weakly or strongly) polarised statements and situations, but it can also apply to intermediate comments and experiences. The perceptual structure of the dimensions involved modulates the effect.     

New perspectives in assessing deception: The evolution of the truth machine

In recent years a growing interest has arisen in the development of tools for the detection of deception. Since William M. Marston's first publication (1917) on the use of the polygraph as a lie detector, the application of this tool, commonly known as the truth machine, has evolved. Modern technologies are now trying to push the issue further, investigating brain activity during deception using functional Magnetic Resonance Imaging (fMRI). The aim of this paper is to summarise the evolution of research from the original use of the polygraph to the use of new technologies in detecting deception, in order to provide an overview of the recent developments on the use of measurements of deception, and promote new research in this highly important domain of applied cognitive psychology.     

Parental assessment and treatment of food selectivity in natural settings

This study evaluated the effects of a parent-conducted functional analysis and treatment consisting of differential reinforcement of an alternative behavior, escape extinction, and demand fading on food selectivity in a young child with autism. Increases in food acceptance at home and in a restaurant were obtained.     

Social cognition and real-life functioning in patient samples with 22q11.2 deletion syndrome with or without psychosis,compared to a large sample of patients with schizophrenia only and healthy controls

Patients with the 22q11.2 deletion syndrome (DS) show an increased risk of developing a psychotic illness lifetime. 22q11.2DS may represent a reliable model for studying the neurobiological underpinnings of schizophrenia. The study of social inference abilities in a genetic condition at high risk for psychosis, like 22q11.2DS, may shed light on the relationships between neurocognitive processes and patients' daily general functioning. The study sample consisted of 1736 participants, divided into four groups: 22q11.2DS patients with diagnosis of psychotic disorder (DEL SCZ, N = 20); 22q11.2DS subjects with no diagnosis of psychosis (DEL, N = 43); patients diagnosed with schizophrenia without 22q11.2DS (SCZ, N = 893); and healthy controls (HC, N = 780). Social cognition was assessed through The Awareness of Social Inference Test (TASIT) and general functioning through the Specific Levels of Functioning (SLoF) scale. We analysed data through regression analysis. The SCZ and DEL groups had similar levels of global functioning; they both had significantly lower SLoF Total scores than HC (p < .001); the DEL SCZ group showed significantly lower scores compared to the other groups (SCZ, p = .004; DEL, p = .003; HC, p < .001). A significant deficit in social cognition was observed in the three clinical groups. In the DEL SCZ and SCZ groups, TASIT scores significantly predicted global functioning (p < .05). Our findings of social cognition deficit in psychosis-prone patients point to the possible future adoption of rehabilitation programmes, like Social Skills Training and Cognitive Remediation, during premorbid stages of psychosis.     

The suppression of reflexive visual and auditory orienting when attention is otherwise engaged

Two experiments were conducted to examine whether abrupt onsets are capable of reflexively capturing attention when they occur outside the current focus of spatial attention, as would be expected if exogenous orienting operates in a truly automatic fashion. The authors established a highly focused attentional state by means of the central presentation of a stream of visual or auditory characters, which participants sometimes had to monitor. No intramodal reflexive cuing effects were observed in either audition or vision when participants performed either an exogenous visual or auditory orthogonal cuing task together with the central focused attention task. These results suggest that reflexive unimodal orienting is not truly automatic. The fact that cuing effects were eliminated under both unimodal and cross-modal conditions is consistent with the view that auditory and visual reflexive spatial orienting are controlled by a common underlying neural substrate.