Inhibition of the LH Surge by Restraint Stress in Cyclic Rats: Studies on the Role of GABAA and GABAB Receptors

There is evidence that stress can alter the activity in the brain of gamma-aminobutyricacid (GABA), a neurotransmitter that has been implicated in the regulation of LH secretion. In the present study the role of GABA in the restraint stress-induced inhibition of the LH surge was investigated in the intact cyclic rat. Intracerebroventricular (icv) administration of the GABAA receptor agonist muscimol (0.1, 0.5 or 1 μg) 5 min before the presumed onset of the pro-oestrous LH surge (at 0900 h) caused a dose dependent suppression of the surge. A single dose of the GABAB receptor agonist baclofen (1 μg; icv) injected at 0855 h postponed the onset of the LH surge, and repeated injections at 0855 and 1130 h suppressed the surge. These data indicate that GABA-ergic activity in the brain can inhibit the LH surge in the cyclic rat via GABAA and GABAB receptors. Pro-oestrous rats were subjected to 5 hrs of restraint starting at 0855 h. Pretreatment with the GABAA receptor antagonist bicuculine (1 μg; icv) at 0840, 0940 and 1040 h or pretreatment with the GABAB receptor antagonist phaclofen (10 μg; icv) at 0840 h were ineffective in preventing the restraint-induced inhibition of the LH surge. The results suggest that GABAA and GABAB receptors are not involved in the inhibitory effect of restraint stress on the LH surge.     

Reintegrative Shaming Theory, moral emotions and bullying

This article investigates the usefulness of Reintegrative Shaming Theory (RST) in explaining the bullying of siblings in families and peers in schools. Questionnaires were completed by 182 children aged 11-12 years in ten primary schools in Nicosia, Cyprus, about sibling and peer bullying. A vignette-based methodology was used to investigate children's expectations of the type of shaming their parents would offer in response to their possible wrong doing. Children were also asked questions about the emotions they would have felt (i.e. shame, remorse, guilt or anger) if they were in the position of the child in the vignette. The level of bonding toward each parent was also examined. In agreement with the theory, a path analysis showed that mother bonding influenced children's expectations of the type of shaming offered by parents. Disintegrative shaming (i.e. shaming offered in a stigmatizing or rejecting way) had a direct effect on the way children managed their shame. Shame management directly influenced sibling and peer bullying. Father bonding had no direct or indirect effects in the model. Against the theory, reintegrative shaming (i.e. shaming offered in the context of approving the wrongdoer while rejecting the wrongdoing) did not have a direct effect on shame management. Beyond the postulates of RST, mother bonding-a plausible indicator of family functioning-had a direct effect on sibling and peer bullying. Mother bonding had a stronger effect for boys than for girls. It is concluded that RST is useful in explaining the link between family factors and bullying, and that RST has cross-cultural applicability.     

Development of adolescence‐limited,late‐onset,and persistent offenders from age 8 to age 48

This article investigates the life success at ages 32 and 48 of four categories of males: nonoffenders, adolescence‐limited offenders (convicted only at ages 10–20), late‐onset offenders (convicted only at ages 21–50), and persistent offenders (convicted at both ages 10–20 and 21–50). In the Cambridge Study in Delinquent Development, 411 South London males have been followed up from age 8 to 48 in repeated personal interviews. There was considerable continuity in offending over time. Persistent offenders had the longest criminal careers (averaging 18.4 years), and most of them had convictions for violence. Persistent offenders were leading the most unsuccessful lives at ages 32 and 48, although all categories of males became more successful with age. By age 48, the life success of adolescence‐limited offenders was similar to that of nonoffenders. The most important risk factors at ages 8–18 that predicted which offenders would persist after age 21 were heavy drinking at age 18, hyperactivity at ages 12–14, and low popularity and harsh discipline at ages 8–10. The most important risk factors that predicted which nonoffenders would onset after age 21 were poor housing and low nonverbal IQ at ages 8–10, high neuroticism at age 16, and anti‐establishment attitudes and motoring convictions at age 18. It was suggested that nervousness and neuroticism may have protected children at risk from offending in adolescence and the teenage years. Aggr. Behav. 35:150–163, 2009. © 2009 Wiley‐Liss, Inc.     

School bullying as a predictor of violence later in life: A systematic review and meta-analysis of prospective longitudinal studies

This paper presents results from a thorough systematic review on the efficacy of school bullying (perpetration and victimization) in predicting aggression and violence later in life. Results are based on prospective longitudinal studies. Two meta-analyses are presented examining whether: a) school bullying (perpetration and victimization) is a significant predictor of later aggression and violence, and b) whether each effect remains significant after controlling for other major childhood risk factors which were significantly related to both the predictors and the outcomes. Results are based on extensive searches of the literature. Nineteen electronic databases and 63 journals were searched from the inception of each database or journal through the end of March, 2012. Bullying perpetration at school was a significant predictor of violence (Adjusted OR = 2.04; 95% CI: 1.69–2.45) an average of six years later in life. This value of OR means that bullying perpetration increased the risk of later violence by about two-thirds. The summary effect size for bullying victimization versus violence was markedly smaller but still highly significant (Adjusted OR = 1.42; 95% CI: 1.25–1.62). This value of OR means that victimization increased the risk of later violence by about one-third. Analyses are presented of various potential moderators (such as the number of risk factors controlled for and the length of the follow-up period) in an attempt to explain the significant heterogeneity in effect sizes. Sensitivity analyses are performed on both meta-analyses, and they indicate that overall there is no evidence of publication bias. The overall findings favor the existence of a more general long-term underlying antisocial tendency rather than a more specific underlying violent tendency. Implications of our research for policy and practice are highlighted and future needs in this area of research are indicated.